INT73223

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 78
Total Number 83
Disease Relevance 31.44
Pain Relevance 9.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UPF1) RNA binding (UPF1) helicase activity (UPF1)
cell cycle (UPF1) DNA binding (UPF1) cytoplasm (UPF1)
Anatomy Link Frequency
papillae 6
fibroblasts 2
testis 2
reticulocytes 2
SH-SY5Y 1
UPF1 (Homo sapiens)
UPF1 - N34S (2)
Pain Link Frequency Relevance Heat
ASIC 325 100.00 Very High Very High Very High
Inflammation 176 100.00 Very High Very High Very High
opioid receptor 28 100.00 Very High Very High Very High
cerebral cortex 6 99.92 Very High Very High Very High
Hippocampus 14 99.90 Very High Very High Very High
Nerve growth factor 6 99.84 Very High Very High Very High
drug abuse 415 99.64 Very High Very High Very High
antidepressant 176 99.62 Very High Very High Very High
depression 56 98.92 Very High Very High Very High
Spinal cord 6 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 190 100.00 Very High Very High Very High
Obesity 429 99.98 Very High Very High Very High
Familial Dysautonomia 1331 99.84 Very High Very High Very High
Dengue Hemorrhagic Fever 339 99.84 Very High Very High Very High
Schizophrenia 30 99.84 Very High Very High Very High
Pancreatic Cancer 9 99.84 Very High Very High Very High
Disease 682 99.64 Very High Very High Very High
Drug Dependence 422 99.64 Very High Very High Very High
Keloid Scars 12 99.64 Very High Very High Very High
Cold Sores 4 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The advance rent system: a silent killer
Gene_expression (system) of advance rent
1) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
One male respondent talked about the amount of time he spent working to save enough for his next advance rent:
Gene_expression (next) of advance rent
2) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0.23 Pain Relevance 0.08
Study participants acknowledged that advance rent commitments create a major life struggle and frequently result in severe financial constraints for a range of household expenditures, including food, children’s school fees, and many basic necessities as they “try to save money for future advance rent”:
Gene_expression (commitments) of advance rent
3) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
Another participant who borrowed her initial advance rent money and has yet to finish paying described how this might have resulted in her becoming hypertensive:
Gene_expression (money) of advance rent associated with hypertension
4) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0.28 Pain Relevance 0
Study participants acknowledged that advance rent commitments create a major life struggle and frequently result in severe financial constraints for a range of household expenditures, including food, children’s school fees, and many basic necessities as they “try to save money for future advance rent”:
Gene_expression (future) of advance rent
5) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
How would you describe your perceptions and experiences with the advance rent system commonly practiced in Accra?
Gene_expression (system) of advance rent
6) Confidence 0.41 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872294 Disease Relevance 0 Pain Relevance 0
Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer.
Gene_expression (expression) of transcripts associated with pancreatic cancer
7) Confidence 0.04 Published 1997 Journal Genomics Section Title Doc Link 9441742 Disease Relevance 0.50 Pain Relevance 0.06
Expression of opioid receptor transcripts was restricted to subpopulations of neurons within most regions studied demonstrating differences in the cellular expression patterns of mu, kappa, and delta opioid receptor messenger RNAs in numerous brain regions.
Gene_expression (Expression) of transcripts in neurons associated with opioid receptor
8) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336124 Disease Relevance 0 Pain Relevance 0.88
The expression patterns of opioid receptor transcripts in human brain has not been established with a cellular resolution, in part because of the low apparent abundance of opioid receptor messenger RNAs in human brain.
Gene_expression (expression) of transcripts in brain associated with opioid receptor
9) Confidence 0.04 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336124 Disease Relevance 0 Pain Relevance 0.36
First we showed that 3T3-L1 adipocytes express both NPFF-R1 and NPFF-R2 transcripts, and that NPAF binds adipocyte membranes with a nanomolar affinity as assessed by surface plasmon resonance technology.
Gene_expression (express) of transcripts in adipocyte associated with obesity
10) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.36 Pain Relevance 0.16
RESULTS: Aromatase P450 transcripts were detected in all endometria examined, although the levels varied considerably between samples, ranging from 0.22 to 486.6 arbitrary units (a.u.).
Gene_expression (detected) of transcripts
11) Confidence 0.03 Published 2004 Journal Hum. Reprod. Section Body Doc Link 14747179 Disease Relevance 0.26 Pain Relevance 0
In addition, capsaicin, a stressor, which activates HSV in in vitro models of latency, decreased levels of Zhangfei and trkA transcripts in NGF-differentiated PC12 cells.
Gene_expression (levels) of transcripts associated with cold sores, nerve growth factor and qutenza
12) Confidence 0.03 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.34 Pain Relevance 0.31
Alternative splicing of human transcripts for a subset of the genes that are expressed in dorsal root ganglia, SCN8A (Na(v)1.6), SCN9A (Na(v)1.7), and SCN11A (Na(v)1.9) was characterized in detail.
Gene_expression (expressed) of transcripts in dorsal root ganglia
13) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302875 Disease Relevance 0.05 Pain Relevance 0.17
Such a negative feed-back may be sustained by the over-expression of a diversity of anti-inflammatory transcripts in DSS patients' blood cells at the time of shock.
Gene_expression (expression) of transcripts in blood cells associated with inflammation, shock and dengue hemorrhagic fever
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.60 Pain Relevance 0.09
Moreover, TPH2b transcripts are also readily detectable in rat brain and human small cell lung carcinoma SHP77 cells, which express TPH2 (Figure 1D) together with other neuroendocrine markers.
Gene_expression (detectable) of transcripts in lung associated with small cell lung carcinoma
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.10 Pain Relevance 0.03
Thus, we found that TPH2a and TPH2b pre-mRNAs are extensively RNA-edited by a yet unidentified mechanism, which involves mutually exclusive RNA editing patterns (indicated by Arabic numbers) and leads to the expression of the corresponding TPH2a 1234 and TPH2b 1234 transcripts, respectively (Figure 2C and 2D).
Gene_expression (expression) of transcripts
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.07 Pain Relevance 0.13
This technique was initially used for identifying single nucleotide polymorphisms on the Y chromosome [9] and, thereafter, has been emerging as a sensitive, rapid, low-cost, and reliable method for mutation detection and screening in different genes, including the cystic fibrosis transmembrane conductance regulator gene [10], the hereditary hemochromatosis gene [11], and the BRCA1 and BRCA2 genes [12].
Gene_expression (detection) of mutation associated with fibrosis, cystic fibrosis and iron overload
17) Confidence 0.02 Published 2001 Journal BMC Genet Section Body Doc Link PMC60523 Disease Relevance 0.39 Pain Relevance 0.10
This is the first study showing biphasic changes in the expression of total and specific BDNF transcripts in human cells following antidepressant treatments.
Gene_expression (expression) of transcripts associated with antidepressant
18) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.49
To the best of our knowledge, this is the first study analyzing the effect of antidepressant treatments on the expression of BDNF transcripts in cells of human origin.
Gene_expression (expression) of transcripts associated with antidepressant
19) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0 Pain Relevance 0.39
The present findings show biphasic changes in the expression of total and specific BDNF transcripts following antidepressant treatments in human cells and encourage the use of SH-SY5Y cells as a tool for research of psychotropic drug effects on human genes.


Gene_expression (expression) of transcripts in SH-SY5Y associated with antidepressant
20) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0 Pain Relevance 0.21

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