INT73234

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 12.55
Pain Relevance 8.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
sacroiliac joint 1
blood vessels 1
liver 1
nerves 1
muscle 1
Lbp (Mus musculus)
Pain Link Frequency Relevance Heat
backache 279 100.00 Very High Very High Very High
Osteoarthritis 148 99.98 Very High Very High Very High
Inflammation 120 99.52 Very High Very High Very High
Opioid 45 98.72 Very High Very High Very High
Pain 269 98.36 Very High Very High Very High
unmyelinated 12 91.44 High High
cytokine 15 89.68 High High
cINOD 64 86.16 High High
ischemia 11 84.80 Quite High
opiate 36 80.72 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 311 100.00 Very High Very High Very High
Osteoarthritis 152 99.98 Very High Very High Very High
Extrahepatic Cholestasis 17 99.84 Very High Very High Very High
INFLAMMATION 163 99.52 Very High Very High Very High
Intervertebral Disk Degeneration 20 99.06 Very High Very High Very High
Pain 317 98.36 Very High Very High Very High
Necrosis 14 97.80 Very High Very High Very High
Congenital Anomalies 9 97.08 Very High Very High Very High
Spondylolysis 8 95.68 Very High Very High Very High
Cholestasis 33 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Performance-based back flexion endurance, flexibility, and balance; and self-assessed muscle strength, endurance, flexibility, and balance were not associated with increased LBP intensity.
Neg (not) Positive_regulation (increased) of LBP in muscle
1) Confidence 0.69 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
RESULTS: Persons with low level back endurance showed an insignificantly higher risk of increased LBP intensity (OR = 2.4, P = 0.076), whereas persons with medium level back endurance were at significantly higher risk (OR = 2.7, P = 0.034) compared with those with high level back endurance.
Positive_regulation (increased) of LBP
2) Confidence 0.69 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
The general association between isometric back extension endurance and increased LBP intensity was insignificant (P = 0.067).
Positive_regulation (increased) of LBP
3) Confidence 0.69 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
Asynchronous bone growth resulting in skeletal malalignment was proposed as a possible cause of LBP.
Spec (possible) Positive_regulation (cause) of LBP associated with backache
4) Confidence 0.60 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 1.52 Pain Relevance 1.19
CONCLUSION: The significant association between medium level back extension endurance and increased LBP intensity supports the finding of other studies that particularly back extension endurance is an important physical fitness component in preventing LBP and that the subcomponents of physical fitness are related in different ways to LBP.


Positive_regulation (increased) of LBP
5) Confidence 0.50 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
A familial tendency for LBP was noted in one study in which the child had an increased incidence of reported LBP if one or both parents had a history of LBP.
Positive_regulation (increased) of LBP associated with backache
6) Confidence 0.46 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 1.81 Pain Relevance 1.18
Disc degeneration and spondylolytic symptoms were also noted as sources of LBP.
Positive_regulation (sources) of LBP associated with intervertebral disk degeneration and backache
7) Confidence 0.43 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 2.17 Pain Relevance 1.47
Outcome was defined as an increase above 2 steps in average LBP intensity during the previous year (0-10).
Positive_regulation (increase) of LBP
8) Confidence 0.40 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
A potential link between the adolescent growth spurt and the increased prevalence of LBP was proposed.
Positive_regulation (increased) of LBP associated with backache
9) Confidence 0.40 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 1.37 Pain Relevance 1.14
Persons with medium level self-assessed aerobic fitness were at lower risk of increased LBP intensity compared with those with high level (OR = 0.37, P = 0.02), although the general association of aerobic fitness was insignificant (0.066).
Positive_regulation (increased) of LBP
10) Confidence 0.40 Published 2008 Journal Spine Section Body Doc Link 18317201 Disease Relevance 0 Pain Relevance 0
The increase in TNF-alpha, LBP and CD14 mRNA expression in mouse liver after BCG and LPS injection was significantly decreased by paeoniflorin (100 mg/kg) and was changed by paeoniflorin (25, 50 mg/kg) at different time-point.
Positive_regulation (increase) of LBP in liver
11) Confidence 0.34 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.96 Pain Relevance 0.08
The improved pain control of opioid therapy has allowed the patients suffering from osteoarthritis-induced LBP to become more functionally mobile.
Positive_regulation (induced) of LBP associated with pain, osteoarthritis, opioid and backache
12) Confidence 0.11 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.48 Pain Relevance 1.01
Abnormalities in pathoanatomic structures, such as muscle, tendon, ligament, or the sacroiliac joint produce poor postural control and altered kinematics that facilitate LBP.
Positive_regulation (facilitate) of LBP in sacroiliac joint associated with congenital anomalies and backache
13) Confidence 0.09 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 1.07 Pain Relevance 0.62
Kupffer cells are clearly altered in biliary obstruction [86], with an increased phagocytic ability and a marked proinflammatory response to endotoxin and the lipopolysaccharide binding protein (LBP), which are both increased in extrahepatic cholestasis [85-87].
Positive_regulation (increased) of lipopolysaccharide binding protein in Kupffer cells associated with extrahepatic cholestasis
14) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 1.17 Pain Relevance 0.39
Osteoarthritis-induced LBP represents step-wise structural failure of the lumbar spine that ultimately leads to an ingrowth of nerves and blood vessels.
Positive_regulation (induced) of LBP in nerves associated with osteoarthritis and backache
15) Confidence 0.06 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.94 Pain Relevance 0.74
Osteoarthritis-induced LBP represents step-wise structural failure of the lumbar spine that ultimately leads to an ingrowth of nerves and blood vessels.
Positive_regulation (induced) of LBP in blood vessels associated with osteoarthritis and backache
16) Confidence 0.02 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.94 Pain Relevance 0.74
RESULTS: More than half of the French population in this age group experienced LBP at least one day in the previous 12 months (LBP1), with 17% experiencing LBP for more than 30 days in the previous 12 months (LBP30); prevalence differed between men and women and that of LBP30 increased with age.
Positive_regulation (increased) of LBP30
17) Confidence 0.00 Published 2007 Journal Ann Readapt Med Phys Section Body Doc Link 17631977 Disease Relevance 0.13 Pain Relevance 0

General Comments

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