INT73239

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Context Info
Confidence 0.46
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.65
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp)
Anatomy Link Frequency
lymph node 2
blood 2
spinal cord 2
optic nerves 2
Mbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 23 100.00 Very High Very High Very High
Spinal cord 33 99.84 Very High Very High Very High
Neuritis 18 96.40 Very High Very High Very High
Sciatic nerve 2 95.56 Very High Very High Very High
tolerance 3 92.40 High High
Pain 1 76.20 Quite High
Inflammation 59 72.96 Quite High
antagonist 6 47.48 Quite Low
agonist 35 42.12 Quite Low
Inflammatory mediators 3 18.48 Low Low
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Multiple Sclerosis 137 98.86 Very High Very High Very High
Demyelinating Disease 21 96.62 Very High Very High Very High
Optic Neuritis 16 96.40 Very High Very High Very High
Stress 81 96.24 Very High Very High Very High
Urological Neuroanatomy 10 95.98 Very High Very High Very High
Ceroid Lipofuscinosis 4 95.20 Very High Very High Very High
Hypoxia 1 93.12 High High
Disease 49 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that ALC treatment: (1) upregulates lysosomal H(+)/ATPase gene expression and (2) downregulates myelin basic protein gene expression.
Negative_regulation (downregulates) of Gene_expression (expression) of myelin basic protein gene
1) Confidence 0.46 Published 2008 Journal Mol. Neurobiol. Section Abstract Doc Link 18726077 Disease Relevance 0.51 Pain Relevance 0.08
Numbers of AChR-, MBP-, BPM-reactive Th1 type of cytokine interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha mRNA expression in lymph node cells were markedly suppressed, while transforming growth factor-beta (TGF-beta) mRNA expression was upregulated from nasally tolerized rats, suggesting an active suppression mechanism may act partly in the induction of tolerance.
Negative_regulation (suppressed) of Gene_expression (expression) of MBP in lymph node associated with necrosis, cancer, tolerance and cytokine
2) Confidence 0.39 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9562316 Disease Relevance 1.13 Pain Relevance 0.49
Decreased expression of MBP and CNPase was seen in the pathologic optic nerves, along with evidence of gliosis and ongoing myelin degradation indicated by the presence of MBP fragment.
Negative_regulation (Decreased) of Gene_expression (expression) of MBP in optic nerves
3) Confidence 0.30 Published 2006 Journal J Neuroophthalmol Section Body Doc Link 16845306 Disease Relevance 0.26 Pain Relevance 0
Parallel to MMP-9 upregulation and MPO overactivity, the demyelinating lesion, assessed by myelin basic protein (MBP) levels in spinal cord, was higher in the EAE+S group than in EAE: Western blot analysis in figure 2C showed a consistent decrease in MBP levels in spinal cord homogenates from the EAE group 21 days after MOG inoculation, but not in EAE-induced animals submitted to stress (EAE+S) (F: 10,17, dF: 13).


Negative_regulation (decrease) of Gene_expression (levels) of MBP in spinal cord associated with stress, multiple sclerosis, urological neuroanatomy, demyelinating disease and spinal cord
4) Confidence 0.19 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 2.14 Pain Relevance 0.31
by the strong reduction of myelin basic protein (MBP) expression (Figure 2(b)).
Negative_regulation (reduction) of Gene_expression (expression) of MBP
5) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.44 Pain Relevance 0
Similarly, no differences were observed for numbers of myelin basic protein-reactive blood MNC expressing any of these cytokines after subgrouping according to these variables.
Negative_regulation (numbers) of Gene_expression (expressing) of myelin basic protein-reactive in blood associated with cytokine
6) Confidence 0.00 Published 1998 Journal Neurology Section Abstract Doc Link 9443483 Disease Relevance 1.17 Pain Relevance 1.08

General Comments

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