INT73252

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 124
Total Number 125
Disease Relevance 59.48
Pain Relevance 18.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
T cells 11
DCs 10
macrophages 8
lung 7
cornea 7
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 727 100.00 Very High Very High Very High
substance P 166 100.00 Very High Very High Very High
Inflammation 2228 99.96 Very High Very High Very High
agonist 388 99.92 Very High Very High Very High
cytokine 1220 99.90 Very High Very High Very High
Inflammatory stimuli 7 99.88 Very High Very High Very High
behavioral therapy 7 99.84 Very High Very High Very High
imagery 145 99.68 Very High Very High Very High
adenocard 4 99.52 Very High Very High Very High
mu opioid receptor 21 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 730 100.00 Very High Very High Very High
Nicotine Addiction 55 100.00 Very High Very High Very High
Decompression Sickness 34 100.00 Very High Very High Very High
Arthritis 388 99.96 Very High Very High Very High
Infection 966 99.92 Very High Very High Very High
INFLAMMATION 2285 99.72 Very High Very High Very High
Cancer 2199 99.72 Very High Very High Very High
Colitis 369 99.56 Very High Very High Very High
Psychosis 7 99.50 Very High Very High Very High
Nociception 8 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were 10 cases of chamber-induced altitude DCS observed.
Positive_regulation (induced) of DCS associated with decompression sickness
1) Confidence 0.59 Published 2009 Journal Aviat Space Environ Med Section Abstract Doc Link 19522370 Disease Relevance 0.53 Pain Relevance 0.07
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (activated) of DCs associated with agonist
2) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.56 Pain Relevance 0.09
CONCLUSIONS: The accreditation of DCs has been a central to the ESMO initiative to improve the palliative care provided by oncologists and oncology centers.
Positive_regulation (accreditation) of DCs
3) Confidence 0.42 Published 2010 Journal Ann. Oncol. Section Body Doc Link 19654197 Disease Relevance 0 Pain Relevance 0
However, our data suggest that the presence of such cells in situ may lead to "clinical benefit' by potently activating infiltrated DCs to mature.
Positive_regulation (activating) of DCs
4) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.94 Pain Relevance 0
Although it is highly unlikely that a pure psychotic episode will arise as a result of DCS, physicians caring for divers with symptoms of DCS or AGE and acute psychosis may consider a trial of recompression therapy while completing the medical evaluation.
Positive_regulation (result) of DCS associated with psychosis, decompression sickness and cva
5) Confidence 0.39 Published 2001 Journal Undersea Hyperb Med Section Abstract Doc Link 12067150 Disease Relevance 2.25 Pain Relevance 0.31
Improved 'wording' of certain items, e.g. to avoid double negatives, could further increase the factorial validity of the DCS.
Positive_regulation (increase) of DCS
6) Confidence 0.39 Published 2001 Journal Patient Educ Couns Section Abstract Doc Link 11722854 Disease Relevance 0.29 Pain Relevance 0.07
Functionally, treatment of DCs with endomorphin 1 (EM1), a specific agonist of MOR, can inhibit the forskolin-induced formation of cyclic adenosine monophosphate level in activated DCs.
Positive_regulation (activated) of DCs in DCs associated with adenocard, mu opioid receptor and agonist
7) Confidence 0.35 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.54
Moreover, EM1 treatment resulted in less activation of p38 MAPK and more activation of ERK signaling in lipopolysaccharide-stimulated DCs.
Positive_regulation (activation) of DCs in DCs
8) Confidence 0.33 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.53
Our results suggest that MOR is inducibly expressed on activated DCs and functionally mediates EM1-induced effects on DCs.
Positive_regulation (activated) of DCs in DCs associated with mu opioid receptor
9) Confidence 0.33 Published 2009 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 19189219 Disease Relevance 0 Pain Relevance 0.49
The infiltrated DCs were mostly recruited to the periphery of thermal lesions after hifu exposure
Positive_regulation (infiltrated) of DCs
10) Confidence 0.30 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.71 Pain Relevance 0
In vitro stimulation of DCs with HIFU-treated tumor cells and assay for their maturation status
Positive_regulation (stimulation) of DCs associated with cancer
11) Confidence 0.30 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.25 Pain Relevance 0
Mechanisms of Rac activation in DCs are unclear.
Positive_regulation (activation) of DCs
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.08 Pain Relevance 0.12
DCs are activated in the periphery where they internalize and process the antigen [7], [8].
Positive_regulation (activated) of DCs
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.59 Pain Relevance 0.15
Furthermore, up-regulated levels of the maturation markers CD80 and CD86 were found in CD11c+ subpopulation recovered from HIFU-treated tumors (Figure 6B, D, and 6E), indicating HIFU-treatment induced infiltrated DCs towards a mature phenotype.
Positive_regulation (induced) of DCs in CD86 associated with cancer
14) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.91 Pain Relevance 0
We found that the infiltrated DCs were mostly recruited to the periphery of thermal lesions after HIFU exposure and the tumor cells at the periphery of HIFU-induced thermal lesions could more effectively stimulated DCs to mature.
Positive_regulation (stimulated) of DCs associated with cancer
15) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.17 Pain Relevance 0
Given the central role of DCs maturation in the development of anti-tumor immune response, it is reasonable to speculate that an optimized HIFU strategy that can more effectively activate DCs to mature should have potential to elicit a stronger anti-tumor immunity.
Positive_regulation (activate) of DCs associated with cancer
16) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.15 Pain Relevance 0
These data therefore provide evidence that tumor cells at the periphery of thermal lesions can more effectively activate DCs to mature than those within the lesions.
Positive_regulation (activate) of DCs associated with cancer
17) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.88 Pain Relevance 0.05
Based on these observations, we have postulated that in situ activation of DCs inside HIFU-treated tumor tissue may constitute an important mechanism for HIFU-induced anti-tumor immunity.
Positive_regulation (activation) of DCs in DCs associated with cancer
18) Confidence 0.28 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.20 Pain Relevance 0.03
Previously we demonstrated feasibility of manipulating such signals using siRNA on DCs in order to generate immunomodulatory DCs in a reproducible manner by silencing IL-12p35 [14].
Positive_regulation (generate) of DCs
19) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.25 Pain Relevance 0.08
A consequence of the increase in both numbers of rDCs and the frequency that was activated was a 30–50 fold increase in total activated DCs in the lung.


Positive_regulation (increase) of DCs in lung
20) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.10 Pain Relevance 0

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