INT7326

Context Info Confidence 0.72 First Reported 1989 Last Reported 2008 Negated 1 Speculated 1 Reported most in Abstract Documents 83 Total Number 84 Disease Relevance 13.50 Pain Relevance 35.33

cytosol (Th) mitochondrion (Th) nucleus (Th) response to stress (Th) cytoplasm (Th)

Anatomy Link Frequency brain 5 VMN 5 locus coeruleus 3 hearts 3 neurons 3 Th (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 98 100.00 Dopamine 68 100.00 Catecholamine 66 100.00 Neuropeptide 51 100.00 Cholecystokinin 33 100.00 Calcitonin gene-related peptide 14 100.00 dopamine receptor 10 100.00 adenocard 8 100.00 Somatostatin 4 100.00 calcitonin gene related peptide 1 100.00

Disease Link Frequency Relevance Heat Generalized Anxiety Disorder 8 99.92 Polycystic Ovary Syndrome 87 99.42 Aids-related Complex 16 98.76 Stress 61 98.62 Hypoxia 20 98.62 Eating Disorder 3 98.48 Infarction 1 98.20 Ganglion Cysts 24 98.16 Pheochromocytoma 5 98.00 Injury 6 97.62

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.

Transcription (levels) of Tyrosine hydroxylase in locus coeruleus associated with locus ceruleus

1) Confidence 0.72 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.31

Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.

Transcription (levels) of TH in locus coeruleus associated with locus ceruleus

2) Confidence 0.72 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.31

These differential effects suggest suppression of endogenous TH gene transcription, targeted degradation of TH mRNA or both.

Transcription (transcription) of TH gene

3) Confidence 0.72 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.19

The total RNA was isolated from the adrenals and tyrosine hydroxylase (TH) mRNA expression was estimated by hybridisation with cDNA after Northern blot.

Transcription (expression) of tyrosine hydroxylase

4) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0

Adrenal tyrosine hydroxylase (TH) mRNA level was significantly elevated in both PH and laparotomized rats, however 24 h after the surgery they returned to the baseline.

Transcription (level) of TH

5) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0

Adrenal tyrosine hydroxylase (TH) mRNA level was significantly elevated in both PH and laparotomized rats, however 24 h after the surgery they returned to the baseline.

Transcription (level) of tyrosine hydroxylase

6) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0

The total RNA was isolated from the adrenals and tyrosine hydroxylase (TH) mRNA expression was estimated by hybridisation with cDNA after Northern blot.

Transcription (expression) of TH

7) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0

Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.

Transcription (expression) of tyrosine hydroxylase associated with morphine

8) Confidence 0.71 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.70

Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.

Transcription (expression) of TH associated with morphine

9) Confidence 0.71 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.31 Pain Relevance 0.70

Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.

Transcription (transcription) of TH associated with pheochromocytoma

10) Confidence 0.71 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.15 Pain Relevance 0

Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.

Transcription (transcription) of Tyrosine hydroxylase associated with pheochromocytoma

11) Confidence 0.71 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.15 Pain Relevance 0

We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.

Transcription (transcription) of TH

12) Confidence 0.70 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03

We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.

Transcription (transcription) of tyrosine hydroxylase

13) Confidence 0.70 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03

EA might regulate the biosynthesis of DA by altering the TH gene transcription.

Transcription (transcription) of TH gene associated with dopamine

14) Confidence 0.70 Published 1999 Journal Acupunct Electrother Res Section Abstract Doc Link 10579240 Disease Relevance 0 Pain Relevance 1.01

We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone.

Transcription (levels) of TH associated with dopamine

15) Confidence 0.70 Published 2005 Journal Alcohol Alcohol. Section Abstract Doc Link 15897221 Disease Relevance 0 Pain Relevance 0.42

The mRNA of TH and PNMP was also detected in fetal rat hearts before sympathetic innervation.

Transcription (detected) of TH in hearts

16) Confidence 0.69 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15458949 Disease Relevance 0 Pain Relevance 0.11

Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.

Transcription (levels) of TH

17) Confidence 0.69 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18

When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.

Transcription (immunoreactivity) of TH associated with catecholamine and enkephalin

18) Confidence 0.69 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28

When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.

Transcription (immunoreactivity) of tyrosine hydroxylase associated with catecholamine and enkephalin

19) Confidence 0.69 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28

We have used rapid, specific and sensitive solution hybridization assays for the quantitation of tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPenk) mRNA and total cellular RNA to compare ipsilateral and contralateral levels of these RNAs in tissue dissected from the origin and termination of the nigrostriatal pathway of individual rats following sham (vehicle) or 6-hydroxydopamine (6-OHDA) induced lesions of the SN.

Transcription (quantitation) of TH associated with substantia nigra

20) Confidence 0.69 Published 1993 Journal Life Sci. Section Abstract Doc Link 8097862 Disease Relevance 0 Pain Relevance 0.17

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