INT7326

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Context Info
Confidence 0.72
First Reported 1989
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 83
Total Number 84
Disease Relevance 13.50
Pain Relevance 35.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 5
VMN 5
locus coeruleus 3
hearts 3
neurons 3
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 98 100.00 Very High Very High Very High
Dopamine 68 100.00 Very High Very High Very High
Catecholamine 66 100.00 Very High Very High Very High
Neuropeptide 51 100.00 Very High Very High Very High
Cholecystokinin 33 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 100.00 Very High Very High Very High
dopamine receptor 10 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 8 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 87 99.42 Very High Very High Very High
Aids-related Complex 16 98.76 Very High Very High Very High
Stress 61 98.62 Very High Very High Very High
Hypoxia 20 98.62 Very High Very High Very High
Eating Disorder 3 98.48 Very High Very High Very High
Infarction 1 98.20 Very High Very High Very High
Ganglion Cysts 24 98.16 Very High Very High Very High
Pheochromocytoma 5 98.00 Very High Very High Very High
Injury 6 97.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.
Transcription (levels) of Tyrosine hydroxylase in locus coeruleus associated with locus ceruleus
1) Confidence 0.72 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.31
Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.
Transcription (levels) of TH in locus coeruleus associated with locus ceruleus
2) Confidence 0.72 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.31
These differential effects suggest suppression of endogenous TH gene transcription, targeted degradation of TH mRNA or both.
Transcription (transcription) of TH gene
3) Confidence 0.72 Published 2007 Journal Brain Res. Section Abstract Doc Link 17174279 Disease Relevance 0 Pain Relevance 0.19
The total RNA was isolated from the adrenals and tyrosine hydroxylase (TH) mRNA expression was estimated by hybridisation with cDNA after Northern blot.
Transcription (expression) of tyrosine hydroxylase
4) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Adrenal tyrosine hydroxylase (TH) mRNA level was significantly elevated in both PH and laparotomized rats, however 24 h after the surgery they returned to the baseline.
Transcription (level) of TH
5) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Adrenal tyrosine hydroxylase (TH) mRNA level was significantly elevated in both PH and laparotomized rats, however 24 h after the surgery they returned to the baseline.
Transcription (level) of tyrosine hydroxylase
6) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
The total RNA was isolated from the adrenals and tyrosine hydroxylase (TH) mRNA expression was estimated by hybridisation with cDNA after Northern blot.
Transcription (expression) of TH
7) Confidence 0.72 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Transcription (expression) of tyrosine hydroxylase associated with morphine
8) Confidence 0.71 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.70
Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.
Transcription (expression) of TH associated with morphine
9) Confidence 0.71 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.31 Pain Relevance 0.70
Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.
Transcription (transcription) of TH associated with pheochromocytoma
10) Confidence 0.71 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.15 Pain Relevance 0
Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.
Transcription (transcription) of Tyrosine hydroxylase associated with pheochromocytoma
11) Confidence 0.71 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.15 Pain Relevance 0
We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.
Transcription (transcription) of TH
12) Confidence 0.70 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03
We showed that physiological concentrations of butyrate can regulate transcription of tyrosine hydroxylase (TH) and preproenkephalin (ppEnk) gene in PC12 cells.
Transcription (transcription) of tyrosine hydroxylase
13) Confidence 0.70 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.03
EA might regulate the biosynthesis of DA by altering the TH gene transcription.
Transcription (transcription) of TH gene associated with dopamine
14) Confidence 0.70 Published 1999 Journal Acupunct Electrother Res Section Abstract Doc Link 10579240 Disease Relevance 0 Pain Relevance 1.01
We assessed mRNA levels of tyrosine hydroxylase (TH), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone.
Transcription (levels) of TH associated with dopamine
15) Confidence 0.70 Published 2005 Journal Alcohol Alcohol. Section Abstract Doc Link 15897221 Disease Relevance 0 Pain Relevance 0.42
The mRNA of TH and PNMP was also detected in fetal rat hearts before sympathetic innervation.
Transcription (detected) of TH in hearts
16) Confidence 0.69 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15458949 Disease Relevance 0 Pain Relevance 0.11
Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.
Transcription (levels) of TH
17) Confidence 0.69 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18
When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.
Transcription (immunoreactivity) of TH associated with catecholamine and enkephalin
18) Confidence 0.69 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28
When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.
Transcription (immunoreactivity) of tyrosine hydroxylase associated with catecholamine and enkephalin
19) Confidence 0.69 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28
We have used rapid, specific and sensitive solution hybridization assays for the quantitation of tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPenk) mRNA and total cellular RNA to compare ipsilateral and contralateral levels of these RNAs in tissue dissected from the origin and termination of the nigrostriatal pathway of individual rats following sham (vehicle) or 6-hydroxydopamine (6-OHDA) induced lesions of the SN.
Transcription (quantitation) of TH associated with substantia nigra
20) Confidence 0.69 Published 1993 Journal Life Sci. Section Abstract Doc Link 8097862 Disease Relevance 0 Pain Relevance 0.17

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