INT73260

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.65
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
monocyte 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 43 100.00 Very High Very High Very High
Inflammation 37 92.16 High High
aspirin 17 82.88 Quite High
Paracetamol 7 73.64 Quite High
diclofenac 1 62.08 Quite High
COX-2 inhibitor 30 58.68 Quite High
agonist 27 50.04 Quite High
COX2 2 50.00 Quite Low
Arthritis 5 20.16 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Large Cell Carcinoma 7 97.92 Very High Very High Very High
Non-small-cell Lung Cancer 7 97.60 Very High Very High Very High
INFLAMMATION 46 95.20 Very High Very High Very High
Lung Cancer 55 93.80 High High
Apoptosis 10 93.28 High High
Cancer 36 87.84 High High
Adenocarcinoma 9 77.36 Quite High
Malignant Neoplastic Disease 3 69.36 Quite High
Benign Tumor 1 66.64 Quite High
Metastasis 1 63.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two primary genes are responsible for the genetic control of cyclooxygenase, a constitutive gene (COX-1) and its inducible isoform (COX-2) 23, 24, 25.
Regulation (control) of Positive_regulation (inducible) of COX-1
1) Confidence 0.26 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.58 Pain Relevance 0.33
The effects of the compounds towards the cyclooxygenase activity of monocyte PGHS-2 induced in response to lipopolysaccharide (LPS) was evaluated by measuring the levels of PGE2 produced in plasma.
Regulation (effects) of Positive_regulation (induced) of cyclooxygenase in monocyte
2) Confidence 0.23 Published 1997 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 9444611 Disease Relevance 0.26 Pain Relevance 0.33
Another aspect of carcinogenesis is the role of the inducible enzyme, cyclooxygenase (COX)-2.
Regulation (role) of Positive_regulation (inducible) of cyclooxygenase
3) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 1.64 Pain Relevance 0.13
In this study, we examined the effect of removal of NSAID after induction of PGHS with LPS, on the release of PGs, which has not been studied well.
Spec (examined) Regulation (effect) of Spec (examined) Positive_regulation (induction) of PGHS associated with cinod
4) Confidence 0.01 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15256727 Disease Relevance 0.17 Pain Relevance 0.58

General Comments

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