INT73262

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 67
Total Number 67
Disease Relevance 61.01
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
colon 2
MG-63 2
B-cell 2
SiHa 1
plasma 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 24 99.60 Very High Very High Very High
qutenza 34 98.94 Very High Very High Very High
adenocard 7 98.90 Very High Very High Very High
cINOD 120 98.04 Very High Very High Very High
aspirin 45 94.84 High High
withdrawal 14 94.60 High High
palliative 15 90.32 High High
agonist 80 87.44 High High
dexamethasone 4 87.40 High High
Spinal cord 11 86.88 High High
Disease Link Frequency Relevance Heat
Apoptosis 2294 100.00 Very High Very High Very High
Repression 27 100.00 Very High Very High Very High
Disease 299 99.84 Very High Very High Very High
Non-small-cell Lung Cancer 41 99.82 Very High Very High Very High
Nasopharynx Cancer 111 99.78 Very High Very High Very High
Cancer 2192 99.70 Very High Very High Very High
Reprotox - General 1 110 99.70 Very High Very High Very High
Osteogenic Sarcomas 11 99.44 Very High Very High Very High
Lymphatic System Cancer 93 99.32 Very High Very High Very High
Prostate Cancer 209 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoG2 is a potent inhibitor of antiapoptotic Bcl-2 proteins and its treatment could remove the protective effect of Bcl-2 proteins and facilitate apoptosis.
Negative_regulation (inhibitor) of Bcl-2 associated with apoptosis
1) Confidence 0.57 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 1.23 Pain Relevance 0.06
Within 5-10 hr after start of paracetamol exposure, a marked downregulation of both c-myc and bcl-2 mRNA was observed.
Negative_regulation (downregulation) of bcl-2 mRNA associated with paracetamol
2) Confidence 0.53 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9444671 Disease Relevance 0.59 Pain Relevance 0.69
Besides, ATRA downregulation of Ras and Bcl2 was shown to correlate with the activation of let-7a miRNA [12].
Negative_regulation (downregulation) of Bcl2
3) Confidence 0.51 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.60 Pain Relevance 0
Recently, Garzon et al. showed that all-trans retinoic acid (ATRA) downregulation of Bcl2 and Ras was correlated with the activation of miR-15a/miR-16-1 [12].
Negative_regulation (downregulation) of Bcl2
4) Confidence 0.51 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.16 Pain Relevance 0
Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3.
Negative_regulation (down-regulation) of Bcl-2 in A172 associated with qutenza and apoptosis
5) Confidence 0.48 Published 2008 Journal Life Sci. Section Abstract Doc Link 18405923 Disease Relevance 0.40 Pain Relevance 0.72
Finally, immunoblotting indicated that BCL2 protein levels were reduced by approximately 60% despite a lack of change in mRNA levels in HT29 cells overexpressing Par-4, suggesting a genomic mechanism involving translational repression via microRNAs (Figure 2C).


Negative_regulation (reduced) of BCL2 associated with repression
6) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.26 Pain Relevance 0
Here, we have shown that amygdalin induces apoptotic cell death in human DU145 and LNCaP prostate cancer cells by caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax.
Negative_regulation (down-regulation) of Bcl-2 in apoptotic cell associated with prostate cancer, apoptosis and death
7) Confidence 0.44 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.56 Pain Relevance 0.06
Discovery of the bcl-2 gene, an apoptosis inhibitor, in translocation 14;18 (q32;q21) in follicular B-cell lymphomas, followed by the identification of the BCL-2 family in the study of Caenorhabditis elegans, opened new perspectives for the study of tissue morphogenesis and oncogenesis [9,11,18].
Negative_regulation (inhibitor) of bcl-2 in B-cell associated with lymphatic system cancer and apoptosis
8) Confidence 0.42 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.31 Pain Relevance 0
apoptosis in prostate cancer cells through inhibition of Bcl-xL/Bcl-2 functions
[84]. 
Negative_regulation (inhibition) of Bcl-2 associated with apoptosis and reprotox - general 1
9) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 1.25 Pain Relevance 0.07
We previously have reported that ApoG2 is a promising compound that kills nasopharyngeal carcinoma (NPC) cells by inhibiting the antiapoptotic function of Bcl-2 proteins.
Negative_regulation (inhibiting) of Bcl-2 associated with nasopharynx cancer
10) Confidence 0.42 Published 2009 Journal J Transl Med Section Abstract Doc Link PMC2742515 Disease Relevance 0.58 Pain Relevance 0
After treatment with ASA, down-regulation of Bcl2 and CD44v6 expression and up-regulation of nm23 expression were observed in SW480 cells.
Negative_regulation (down-regulation) of Bcl2 in SW480
11) Confidence 0.39 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12423325 Disease Relevance 0.13 Pain Relevance 0
Differential upregulation of the apoptotic mediators p53, Bax, cytochrome c, and caspase-3 and -9, and downregulation of antiapoptotic Bcl-2, was observed in CP.
Negative_regulation (downregulation) of Bcl-2
12) Confidence 0.38 Published 2008 Journal J. Gastroenterol. Section Body Doc Link 18600392 Disease Relevance 0.06 Pain Relevance 0
Bcl2 repression by these miRNAs induced apoptosis in a leukemic cell line model.
Negative_regulation (repression) of Bcl2 associated with repression and apoptosis
13) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.21 Pain Relevance 0
Finally, combined treatment revealed bcl-2 repression and caspase-3 induction did not detect any change but p53 expression did.
Negative_regulation (repression) of bcl-2 associated with repression
14) Confidence 0.37 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 12490308 Disease Relevance 0.75 Pain Relevance 0.52
Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.
Negative_regulation (inhibitor) of Bcl-2 in colon associated with colon cancer and apoptosis
15) Confidence 0.34 Published 2005 Journal Mol. Cancer Ther. Section Title Doc Link 16227396 Disease Relevance 1.21 Pain Relevance 0.19
For instance, miR-34a up-regulation corresponded with a down-regulation of BCL2 protein.
Negative_regulation (down-regulation) of BCL2
16) Confidence 0.33 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2883962 Disease Relevance 0.61 Pain Relevance 0
Our data demonstrate that 3HFD treatment down-regulated Bcl-2 and significantly up-regulated the expression of Bax in MCF-7 cells.
Negative_regulation (regulated) of Bcl-2 in MCF-7
17) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 1.05 Pain Relevance 0.13
More specifically, studies have shown that the expression of the pro-apoptotic effector bax is upregulated and the anti-apoptotic molecule, bcl2 is decreased in AD (Paradis et al 1996; Tamagno et al 2003).
Negative_regulation (decreased) of bcl2 associated with disease and apoptosis
18) Confidence 0.29 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 1.15 Pain Relevance 0.03
Mamalian Bcl-2 protein family of apoptosis-associated proteins consists of members that inhibit apoptosis (Bcl-2, Bcl-xl) and others that induced apoptosis (Bax, Bak, etc.) [26].
Negative_regulation (inhibit) of Bcl-2 associated with apoptosis
19) Confidence 0.29 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.78 Pain Relevance 0.13
Therefore any increase in bcl-2 or decrease in bax will push the balance towards chemo resistance and an increase in bax or decrease in bcl-2 will result in increased apoptosis [26-30].
Negative_regulation (decrease) of bcl-2 associated with apoptosis
20) Confidence 0.28 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.39 Pain Relevance 0

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