INT73263

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 12.86
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
colon 2
HT-29 1
thyroid 1
poly 1
MDCK 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 137 99.60 Very High Very High Very High
aspirin 11 98.96 Very High Very High Very High
Analgesic 4 98.96 Very High Very High Very High
sSRI 8 98.62 Very High Very High Very High
Restless leg syndrome 1 97.24 Very High Very High Very High
Inflammation 28 93.56 High High
fluoxetine 1 91.92 High High
COX2 6 89.36 High High
cytokine 21 88.68 High High
antagonist 6 84.32 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 205 100.00 Very High Very High Very High
Colon Cancer 25 99.84 Very High Very High Very High
Leukemia 76 99.64 Very High Very High Very High
Myeloid Leukemia 52 99.44 Very High Very High Very High
Thyroid Neoplasm 99 99.30 Very High Very High Very High
Epstein-barr Virus 21 99.24 Very High Very High Very High
Carcinoma 4 99.02 Very High Very High Very High
Cancer 241 98.96 Very High Very High Very High
Shock 4 98.30 Very High Very High Very High
Familial Adenomatous Polyposis 1 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within 5-10 hr after start of paracetamol exposure, a marked downregulation of both c-myc and bcl-2 mRNA was observed.
Negative_regulation (downregulation) of c-myc associated with paracetamol
1) Confidence 0.57 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9444671 Disease Relevance 0.59 Pain Relevance 0.69
Indeed, when c-myc levels were decreased by RNA interference, the tumor cell-specific induction of NOXA was abrogated.
Negative_regulation (decreased) of c-myc associated with cancer
2) Confidence 0.57 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.77 Pain Relevance 0
proapoptotic proteins, the expression levels of the proto-oncogene product c-myc were drastically reduced after 24
Negative_regulation (reduced) of c-myc
3) Confidence 0.57 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.75 Pain Relevance 0
PAB induced growth inhibition and apoptosis in HT-29 cells, which were associated with cell cycle arrest at the G(2)/M phase, modulation of cyclin expression and downregulation of the protooncogene c-myc.
Negative_regulation (downregulation) of protooncogene c-myc in HT-29 associated with apoptosis
4) Confidence 0.57 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258704 Disease Relevance 0.65 Pain Relevance 0.15
SSRIs unexpectedly stimulated calcium flux, tyrosine phosphorylation, and down-regulation of the c-myc and nm23 genes in Burkitt lymphoma cells remaining faithful to the biopsy phenotype.
Negative_regulation (down-regulation) of c-myc associated with epstein-barr virus and ssri
5) Confidence 0.57 Published 2003 Journal Blood Section Abstract Doc Link 12515726 Disease Relevance 0.91 Pain Relevance 0.45
downregulation of c-myc, c-myb, and cyclin D2 genes, previously reported, an array ofnon-PPAR?
Negative_regulation (downregulation) of c-myc
6) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.59 Pain Relevance 0.10
VPA appears to induce an increase in the amount of p21WAF1 protein over 48 hours in AML cells, which is independent of p53 levels (whose expression is not modulated by VPA), but appears to be dependent on c-myc, whose mRNA and protein levels decrease in a dose-dependent manner during VPA treatment.
Negative_regulation (decrease) of c-myc associated with myeloid leukemia
7) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.64 Pain Relevance 0.06
In addition to this, while VPA treatment in the cell lines is followed by a decrease of c-myc and an induction of p21, it has been observed that in primary AML cells, only the systematic decrease of c-myc is maintained, without upregulation of p21 expression.
Negative_regulation (decrease) of c-myc associated with myeloid leukemia
8) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.65 Pain Relevance 0
In addition to this, while VPA treatment in the cell lines is followed by a decrease of c-myc and an induction of p21, it has been observed that in primary AML cells, only the systematic decrease of c-myc is maintained, without upregulation of p21 expression.
Negative_regulation (decrease) of c-myc associated with myeloid leukemia
9) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.58 Pain Relevance 0
It has been reported that pemphigus antibodies trigger a rapid turnover and reduction of the nuclear pool of plakoglobin, thereby abolishing plakoglobin's role as a transcriptional repressor of the proto-oncogene c-Myc [24].
Negative_regulation (repressor) of proto-oncogene c-Myc associated with bullous skin disease
10) Confidence 0.42 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.94 Pain Relevance 0
A second inhibitor of c-Myc activity, Nmi, was significantly diminished at 4 h, although not at 1.5 h post-treatment (Table 2).
Negative_regulation (inhibitor) of c-Myc
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0 Pain Relevance 0.49
Although no evidence for gene rearrangements or amplification of the nuclear proto-oncogenes has been noted in thyroid carcinomas, in human MTC samples, both a high frequency of c-myc allelic losses [50] and elevated levels of c-myc and c-jun mRNA have been demonstrated [52].
Negative_regulation (losses) of c-myc in thyroid associated with thyroid neoplasm and carcinoma
12) Confidence 0.42 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.89 Pain Relevance 0
by the downregulation of the c-myc gene in myeloid leukaemia cells [131] and in colon cancer cells [132, 133].
Negative_regulation (downregulation) of c-myc in colon associated with leukemia and colon cancer
13) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.48 Pain Relevance 0.16
Cilostazol reduces proliferation through c-Myc down-regulation in MDCK cells.
Negative_regulation (down-regulation) of c-Myc in MDCK
14) Confidence 0.42 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19545562 Disease Relevance 0.35 Pain Relevance 0.10
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.
Negative_regulation (inhibition) of c-myc associated with analgesic
15) Confidence 0.41 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10993886 Disease Relevance 0.27 Pain Relevance 0.34
Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.
Negative_regulation (block) of c-myc in colon associated with colon cancer
16) Confidence 0.41 Published 2002 Journal Cancer Res. Section Title Doc Link 12414619 Disease Relevance 0.44 Pain Relevance 0.06
The expression levels of heat shock protein 70 (HSP70), c-jun and c-fos genes were remarkably up-regulated and those of c-myc and poly (ADP ribose) polymerase (PARP) were down-regulated in bupivacaine-treated cells.
Negative_regulation (down-regulated) of c-myc in poly associated with shock
17) Confidence 0.41 Published 2003 Journal J Toxicol Sci Section Abstract Doc Link 12820540 Disease Relevance 0.67 Pain Relevance 0
Further, these studies exhibited a series of mechanistic information including free radical scavenging ability, anti-endonucleolytic activity, cytochrome P450 2E1 inhibitory activity, anti-necrotic, anti-apoptotic and anti-carcinogenic activities, modulatory effects on antioxidative and apoptotic regulatory genes such as Bcl2, c-myc and p53, which may be responsible for the novel chemoprotective properties exhibited by GSPE.
Negative_regulation (series) of c-myc associated with apoptosis
18) Confidence 0.41 Published 2002 Journal Indian J. Exp. Biol. Section Abstract Doc Link 12587719 Disease Relevance 0.74 Pain Relevance 0.22
Statistical analysis revealed significant differences between the expression levels of c-myc, VEGFa, TGF-?
Negative_regulation (levels) of c-myc
19) Confidence 0.18 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.29 Pain Relevance 0.13
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of MYC
20) Confidence 0.16 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.65 Pain Relevance 0

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