INT73264

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (NRF1) mitochondrion organization (NRF1) nucleus (NRF1)
DNA binding (NRF1) cytoplasm (NRF1)
Anatomy Link Frequency
skeletal muscle 1
respiratory 1
NRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ultiva 4 96.08 Very High Very High Very High
Opioid 2 94.32 High High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 1 96.56 Very High Very High Very High
Aging 8 96.20 Very High Very High Very High
Stress 10 94.88 High High
Infection 1 93.80 High High
Obesity 11 37.76 Quite Low
Weight Loss 2 21.68 Low Low
Overweight 6 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Appetite Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the molecular mechanism(s) by which caloric restriction lowered oxygen consumption per unit of FFM, we determined expression of genes involved in mitochondrial biogenesis including PPARGC1A, PPARGC1B, NRF1, and TFAM in skeletal muscle—a metabolically active organ [43] reported to be involved in the aging process [44] and oxidative stress [6].
Spec (determined) Gene_expression (expression) of NRF1 in skeletal muscle associated with stress and aging
1) Confidence 0.70 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.33 Pain Relevance 0
After PMNL activation, the production of oxygen radicals during the respiratory burst (RB) denature the phagocytosed micro-organisms.
Gene_expression (production) of respiratory burst in respiratory
2) Confidence 0.22 Published 1997 Journal Anaesthesiol Reanim Section Abstract Doc Link 9445533 Disease Relevance 0.19 Pain Relevance 0.48

General Comments

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