INT73266

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 29.09
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
Anatomy Link Frequency
eye 3
BxPC-3 3
macrophages 1
myometrium 1
tear 1
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 16 98.88 Very High Very High Very High
Kinase C 56 96.84 Very High Very High Very High
Ultiva 4 96.40 Very High Very High Very High
Opioid 81 94.64 High High
agonist 99 92.16 High High
melanocortin 1 receptor 2 89.36 High High
Inflammatory response 27 84.56 Quite High
Inflammation 227 83.60 Quite High
cytokine 82 71.04 Quite High
cINOD 47 66.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 1199 100.00 Very High Very High Very High
Retinoblastoma 286 100.00 Very High Very High Very High
Papillomavirus Infection 107 100.00 Very High Very High Very High
Disorders Of The Lacrimal System 353 99.98 Very High Very High Very High
Conjunctivitis 4 99.84 Very High Very High Very High
Endometriosis 16 99.60 Very High Very High Very High
Colon Cancer 220 99.44 Very High Very High Very High
Osteogenic Sarcomas 162 99.20 Very High Very High Very High
Infection 223 99.16 Very High Very High Very High
Mycobacterial Infection 4 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear expression of p16, pRb, and cyclin D1 proteins was examined by immunohistochemistry.
Spec (examined) Gene_expression (expression) of pRb
1) Confidence 0.70 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616093 Disease Relevance 0.24 Pain Relevance 0
p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions.
Gene_expression (expression) of pRb associated with endometriosis, dismenorea and retinoblastoma
2) Confidence 0.70 Published 2006 Journal Fertil. Steril. Section Title Doc Link 16616093 Disease Relevance 0.30 Pain Relevance 0.19
In contrast, pRb was detected in 28% of endometriosis cases but not in any adenomyotic tissues.
Neg (not) Gene_expression (detected) of pRb
3) Confidence 0.70 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616093 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: To investigate the expression of p16, retinoblastoma (pRb), and cyclin D1 oncoproteins in endometriomas and adenomyosis.
Spec (investigate) Gene_expression (expression) of pRb associated with endometriosis, dismenorea and retinoblastoma
4) Confidence 0.70 Published 2006 Journal Fertil. Steril. Section Abstract Doc Link 16616093 Disease Relevance 0.52 Pain Relevance 0.17
B activation on myometrial PRA, PRB or ER alpha expression.
Gene_expression (expression) of PRB
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.52 Pain Relevance 0.13
In the model we assumed that PRB expression is due to protein kinase A (PKA) induced CAAT/enhancer-binding protein beta (C/EBP) expression; which then binds to the CAAT site of the PRB promoter (Figure 6).
Gene_expression (expression) of PRB
6) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0 Pain Relevance 0.10
Other important genes include CDK4/6 and retinoblastoma (RB1), which encode downstream proteins in the same pathway as p16/INK4a and p14/ARF.
Gene_expression (/) of retinoblastoma associated with retinoblastoma
7) Confidence 0.65 Published 2009 Journal Clin. Dermatol. Section Abstract Doc Link 19095153 Disease Relevance 1.10 Pain Relevance 0.09
proteins Bcl-2, COX-2, and XIAP in retinoblastoma protein (RB)-deficient human
Gene_expression (deficient) of RB associated with retinoblastoma
8) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.13 Pain Relevance 0.37
Expression of total Rb protein was not decreased from baseline values after 21 hours of OGF treatment using an antibody at 1:200 dilution.
Gene_expression (Expression) of Rb associated with retinoblastoma
9) Confidence 0.62 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
To elucidate the role of Rb in OGF-induced BxPC-3 cell growth inhibition, Rb expression and the phosphorylated state of Rb were assessed in synchronized BxPC-3 cells.
Gene_expression (expression) of Rb in BxPC-3 associated with retinoblastoma
10) Confidence 0.62 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.81 Pain Relevance 0
In order to do this we assumed that the protective effect of progesterone would be mediated by PRB [9], [10], and the activity of PRB is determined by the level of tissue PRB expression.
Gene_expression (expression) of PRB
11) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.31 Pain Relevance 0
B activation led to an increase in PRA and PRB mRNA and protein expression.
Gene_expression (expression) of PRB
12) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.15 Pain Relevance 0
B induction of PRB expression through protein kinase A and CCAAT/enhancer-binding protein (CEBP) and PRA expression indirectly through MAP kinase and AP-1 activation (Figure 6).


Gene_expression (expression) of PRB
13) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.42 Pain Relevance 0.27
B activation PRA protein increased 14 fold above baseline (Figure 1A and 1B); PRB mRNA and protein expression increased 4.2 fold (Figure 2A and 2B respectively).
Gene_expression (expression) of PRB
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.25 Pain Relevance 0
The following antibodies were purchased from commercial sources: phospho-Rb (Ser795), phospho-Rb (Ser807/811) (Cell Signaling Technology, Beverly, MA); Cdk2, p57 (Santa Cruz Biotechnology, Santa Cruz, CA); p21, p27, total Rb (BD PharMingen, San Diego, CA); ?
Gene_expression (total) of Rb associated with retinoblastoma
15) Confidence 0.54 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.29 Pain Relevance 0
Other important genes include CDK4/6 and retinoblastoma (RB1), which encode downstream proteins in the same pathway as p16/INK4a and p14/ARF.
Gene_expression (/) of RB1 associated with retinoblastoma
16) Confidence 0.53 Published 2009 Journal Clin. Dermatol. Section Abstract Doc Link 19095153 Disease Relevance 1.10 Pain Relevance 0.09
Left branch shows distinctive underexpression and loss of expression areas with genes such as IFNGR2, interleukin 2, laminin B1, MSH2, MSH6 CASP8 and 10, RB1, PCNA, EGFR and PGS2, among others, and a few overexpressed genes such as MIF, CDK 2, 5, and 7, RPSA, JUP and ITGAE.
Gene_expression (expression) of RB1
17) Confidence 0.52 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.51 Pain Relevance 0.03
To elucidate the role of Rb in OGF-induced BxPC-3 cell growth inhibition, Rb expression and the phosphorylated state of Rb were assessed in synchronized BxPC-3 cells.
Gene_expression (expression) of Rb in BxPC-3 associated with retinoblastoma
18) Confidence 0.48 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.87 Pain Relevance 0
B activation leads to an increase in Cox2 mRNA levels from 0.00054 mM at pre-labor to 0.28 ┬ÁM at labor, and a 15 fold increase in PRA expression and a 4.2 fold increase in PRB expression with labor.
Gene_expression (expression) of PRB
19) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811723 Disease Relevance 0.39 Pain Relevance 0.10
The following antibodies were purchased from commercial sources: phospho-Rb (Ser795), phospho-Rb (Ser807/811) (Cell Signaling Technology, Beverly, MA); Cdk2, p57 (Santa Cruz Biotechnology, Santa Cruz, CA); p21, p27, total Rb (BD PharMingen, San Diego, CA); ?
Gene_expression (sources) of Rb associated with retinoblastoma
20) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.29 Pain Relevance 0

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