INT73301

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Context Info
Confidence 0.01
First Reported 1998
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACTA1) cytoplasm (ACTA1)
Anatomy Link Frequency
myocardium 1
ACTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 7 99.18 Very High Very High Very High
ischemia 3 87.76 High High
antagonist 5 82.08 Quite High
Onset of action 1 59.80 Quite High
Angina 1 46.16 Quite Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypertension 4 91.44 High High
Cv Unclassified Under Development 3 87.76 High High
Pressure Volume 2 Under Development 1 83.00 Quite High
Injury 2 70.12 Quite High
Coronary Artery Disease 1 52.08 Quite High
Cv General 3 Under Development 1 46.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amlodipine, but not nifedipine, prevented an increase in the relative amount of V3 myosin heavy chain isoform and suppressed an increase in mRNA levels of beta-myosin heavy chain, skeletal alpha-actin, and type 1 collagen.
Positive_regulation (increase) of alpha-actin
1) Confidence 0.01 Published 1998 Journal Hypertension Section Abstract Doc Link 9449387 Disease Relevance 0.29 Pain Relevance 0.14
NE treatment induced intranuclear translocation of PKC-betaI in cardiac myocytes at 10 min and increased skeletal alpha-actin and beta-MHC mRNAs in the myocardium at 4-24 h.
Positive_regulation (increased) of alpha-actin in myocardium associated with kinase c
2) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233047 Disease Relevance 0.29 Pain Relevance 0.38

General Comments

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