INT73309

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Title
Documents 14
Total Number 16
Disease Relevance 9.55
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
knee 4
capsule 2
cartilage 2
epithelial cells 2
platelet 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 27 100.00 Very High Very High Very High
Inflammation 15 100.00 Very High Very High Very High
COX2 13 100.00 Very High Very High Very High
dexamethasone 4 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
cOX1 1 100.00 Very High Very High Very High
tolerance 1 100.00 Very High Very High Very High
Pain management 3 99.80 Very High Very High Very High
Opioid 4 99.08 Very High Very High Very High
Pain 5 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 100.00 Very High Very High Very High
Natriuresis 1 99.84 Very High Very High Very High
Cancer 42 99.80 Very High Very High Very High
Pain 7 99.80 Very High Very High Very High
Necrosis 2 99.56 Very High Very High Very High
Capsule Opacification 114 99.44 Very High Very High Very High
Rheumatoid Arthritis 1 96.80 Very High Very High Very High
Stress 2 96.72 Very High Very High Very High
Apoptosis 44 96.12 Very High Very High Very High
Osteoarthritis 2 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 specific inhibitors have anti-inflammatory and analgesic properties, and are effective in managing a wide range of chronic and acute painful conditions such as adult rheumatoid arthritis, osteoarthritis, migraine, primary dysmenorrhea and postoperative pain.
Regulation (effective) of Negative_regulation (inhibitors) of Cyclooxygenase-2 associated with pain, inflammation, migraine, analgesic, dismenorea, rheumatoid arthritis, perioperative pain and osteoarthritis
1) Confidence 0.44 Published 2005 Journal Expert Rev Neurother Section Abstract Doc Link 15853470 Disease Relevance 0.79 Pain Relevance 0.98
OBJECTIVE: To assess the effect of combined preoperative and postoperative administration of a selective inhibitor of cyclooxygenase 2 on opioid consumption and outcomes after total knee arthroplasty (TKA).
Regulation (effect) of Negative_regulation (inhibitor) of cyclooxygenase 2 in knee
2) Confidence 0.44 Published 2003 Journal JAMA Section Body Doc Link 14612477 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVE: To assess the effect of perioperative administration of a selective cyclooxygenase 2 inhibitor (celecoxib) on pain management and recovery of function after total knee arthroplasty (TKA).
Regulation (effect) of Negative_regulation (inhibitor) of cyclooxygenase 2 in knee associated with pain management and cox2
3) Confidence 0.44 Published 2009 Journal Zhonghua Wai Ke Za Zhi Section Abstract Doc Link 19563006 Disease Relevance 0.17 Pain Relevance 0.22
As a consequence, it is not surprising that clinical data verify that selective inhibitors of cyclooxygenase-2 affect renal function to a degree similar to that which has previously been documented with nonselective nonsteroidal anti-inflammatory drugs.
Regulation (affect) of Negative_regulation (inhibitors) of cyclooxygenase-2 associated with inflammation and cinod
4) Confidence 0.39 Published 2001 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 11496053 Disease Relevance 0.19 Pain Relevance 0.10
A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer.
Regulation (role) of Negative_regulation (inhibitors) of cyclooxygenase-2 associated with cancer and cox2
5) Confidence 0.18 Published 2002 Journal Semin. Oncol. Section Title Doc Link 12138405 Disease Relevance 0.97 Pain Relevance 0.32
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
Regulation (Effects) of Negative_regulation (inhibition) of cyclooxygenase-2 associated with natriuresis and cox1
6) Confidence 0.15 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10215647 Disease Relevance 0.36 Pain Relevance 0.20
Effect of a nonprotein bioactive agent on the reduction of cyclooxygenase-2 and tumor necrosis factor-alpha in human intervertebral disc cells in vitro.
Regulation (Effect) of Negative_regulation (reduction) of cyclooxygenase-2 in intervertebral disc associated with necrosis, cancer and analgesic
7) Confidence 0.14 Published 2008 Journal Journal of neurosurgery. Spine Section Title Doc Link 18976171 Disease Relevance 0.38 Pain Relevance 0.20
Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control.
Regulation (Effect) of Negative_regulation (inhibitor) of cyclooxygenase type-2 associated with pain and opioid
8) Confidence 0.13 Published 2002 Journal Anesthesiology Section Title Doc Link 12170040 Disease Relevance 0.10 Pain Relevance 0.29
In this study we investigated at cellular level the influence of two anti-inflammatory drugs-dexamethasone and indomethacin--and an experimental specific cyclooxygenase-2 inhibitor, BF389, on the production of the pro-inflammatory cytokine IL-6 and the inflammatory mediator PGE2 by human astrocytes.
Spec (investigated) Regulation (influence) of Negative_regulation (inhibitor) of cyclooxygenase-2 in astrocytes associated with inflammation, cinod, dexamethasone and cytokine
9) Confidence 0.13 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 1.00 Pain Relevance 0.56
OBJECTIVE: To simultaneously study the effect of a selective cyclooxygenase-2 (COX-2) inhibitor and that of a classic non-steroidal anti-inflammatory drug (NSAID) on the expression of pro-inflammatory genes in the cartilage of patients with severe knee osteoarthritis (OA) and in cultured human OA chondrocytes.
Regulation (effect) of Negative_regulation (inhibitor) of cyclooxygenase-2 in cartilage associated with inflammation, knee osteoarthritis, cinod and osteoarthritis
10) Confidence 0.11 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 18547825 Disease Relevance 0.55 Pain Relevance 0.45
The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin?
Regulation (role) of Negative_regulation (inhibitors) of cyclooxygenase-2 associated with cancer and cox2
11) Confidence 0.06 Published 2004 Journal Pharmacol. Res. Section Title Doc Link 15458769 Disease Relevance 1.45 Pain Relevance 0.20
In addition to inhibition of cell proliferation and increased apoptosis, many mechanisms have been proposed to explain the anti-carcinogenic effect of curcumin, including its anti-inflammatory and antioxidant activity, induction of phase-II detoxification enzymes, inhibition of cyclooxygenase 2 (COX-2), effect on AP-1 and NF?
Regulation (effect) of Negative_regulation (inhibition) of cyclooxygenase 2 associated with inflammation, cox2 and apoptosis
12) Confidence 0.05 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 1.30 Pain Relevance 0.15
Effects of cyclooxygenase-2 inhibitors on epithelial-mesenchymal transition of lens epithelial cells
Regulation (Effects) of Negative_regulation (inhibitors) of cyclooxygenase-2 in epithelial cells
13) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.39 Pain Relevance 0
Effects of cyclooxygenase-2 inhibitors on posterior capsule opacification formation
Regulation (Effects) of Negative_regulation (inhibitors) of cyclooxygenase-2 in capsule associated with capsule opacification
14) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.54 Pain Relevance 0
Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial.
Regulation (Effects) of Negative_regulation (inhibitor) of cyclooxygenase-2 in platelet
15) Confidence 0.02 Published 2000 Journal J Clin Pharmacol Section Title Doc Link 10664917 Disease Relevance 0.31 Pain Relevance 0.40
[Renal tolerance of selective inhibitors of cyclooxygenase type 2].
Regulation (tolerance) of Negative_regulation (inhibitors) of cyclooxygenase type 2 associated with tolerance
16) Confidence 0.01 Published 2001 Journal Presse Med Section Title Doc Link 11712212 Disease Relevance 0.97 Pain Relevance 0.42

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