INT73311

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Context Info
Confidence 0.08
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.71
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Pdpn) embryo development (Pdpn) signal transducer activity (Oprm1)
cell proliferation (Pdpn) signal transduction (Pdpn) cell adhesion (Pdpn)
Oprm1 (Rattus norvegicus)
Pdpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 9 100.00 Very High Very High Very High
opioid receptor 3 99.00 Very High Very High Very High
Opioid 3 98.84 Very High Very High Very High
agonist 3 97.68 Very High Very High Very High
Enkephalin 9 89.96 High High
MU agonist 3 74.04 Quite High
Analgesic 9 50.00 Quite Low
Immobilon 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Respiratory Tract Infection 12 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data also show that the stereoisomers of RTI-4614-4 probably bind to different domains of the mu receptor and suggest that manipulation of stereochemistry may be a useful tool for designing domain-specific ligands.
mu receptor Binding (bind) of RTI-4614-4 associated with respiratory tract infection
1) Confidence 0.08 Published 1998 Journal Synapse Section Abstract Doc Link 9450512 Disease Relevance 0.27 Pain Relevance 0.37
Viewed collectively, these data suggest that the region from the N terminal to the start of the TMH3 of the mu opioid receptor determines the binding affinity of RTI-4614-4 and its isomers and that the e3 loop also plays a major role in determining the binding affinity of mu agonist peptides.
mu opioid receptor Binding (affinity) of RTI-4614-4 associated with respiratory tract infection, agonist and mu opioid receptor
2) Confidence 0.06 Published 1998 Journal Synapse Section Abstract Doc Link 9450512 Disease Relevance 0.26 Pain Relevance 0.39
The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
mu opioid receptor Binding (bind) of RTI-4614-4 associated with respiratory tract infection and mu opioid receptor
3) Confidence 0.04 Published 1998 Journal Synapse Section Title Doc Link 9450512 Disease Relevance 0.18 Pain Relevance 0.31

General Comments

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