INT73314

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 133
Total Number 137
Disease Relevance 67.78
Pain Relevance 27.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
neurons 11
neuronal 6
ARC 6
caudate-putamen 5
dorsal 5
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 527 100.00 Very High Very High Very High
amygdala 347 100.00 Very High Very High Very High
opioid receptor 33 100.00 Very High Very High Very High
narcan 15 100.00 Very High Very High Very High
Dorsal horn neuron 4 99.98 Very High Very High Very High
Hippocampus 1134 99.92 Very High Very High Very High
primary somatosensory cortex 600 99.84 Very High Very High Very High
antidepressant 115 99.84 Very High Very High Very High
qutenza 9 99.84 Very High Very High Very High
Hyperalgesia 16 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 4183 100.00 Very High Very High Very High
Urological Neuroanatomy 16 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 81 99.82 Very High Very High Very High
Hyperalgesia 17 99.82 Very High Very High Very High
Retinal Degeneration 174 99.80 Very High Very High Very High
Diabetes Mellitus 35 99.24 Very High Very High Very High
Cognitive Disorder 445 99.20 Very High Very High Very High
Generalized Anxiety Disorder 117 98.92 Very High Very High Very High
Appetite Loss 65 98.56 Very High Very High Very High
Hyperphagia 39 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity-regulated cytoskeleton-associated protein Arc is targeted to dendrites and coexpressed with mu-opioid receptors in postnatal rat caudate-putamen nucleus.
Gene_expression (coexpressed) of Arc in caudate-putamen associated with aids-related complex and mu opioid receptor
1) Confidence 0.78 Published 2004 Journal J. Neurosci. Res. Section Title Doc Link 15248288 Disease Relevance 0.52 Pain Relevance 0.16
Our results suggest a correlation between Arc expression in dendritic spines during postnatal development and the onset of synaptogenesis in opioid-responsive neurons in the rat CPN.
Gene_expression (expression) of Arc in spines associated with aids-related complex and opioid
2) Confidence 0.78 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.56 Pain Relevance 0.26
Dendritic expression of the activity-regulated cytoskeleton-associated protein (Arc) is dramatically enhanced by increased synaptic activity in adult brain.
Gene_expression (expression) of activity-regulated cytoskeleton-associated protein in adult brain associated with aids-related complex
3) Confidence 0.78 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.31 Pain Relevance 0.11
Dendritic expression of the activity-regulated cytoskeleton-associated protein (Arc) is dramatically enhanced by increased synaptic activity in adult brain.
Gene_expression (expression) of Arc in adult brain associated with aids-related complex
4) Confidence 0.78 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.31 Pain Relevance 0.13
An immunohistochemical method was employed to detect the expression of Arc, which was used as a plasticity marker to trace the brain areas that contribute to the formation of the place aversion.
Gene_expression (expression) of Arc in brain
5) Confidence 0.77 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19262551 Disease Relevance 0 Pain Relevance 0
In the present study, we examined the expression of Arc protein induced by conditioned naloxone-precipitated drug withdrawal in different brain regions of acute morphine-dependent rats.
Spec (examined) Gene_expression (expression) of Arc in brain associated with aids-related complex, narcan, withdrawal and morphine
6) Confidence 0.77 Published 2009 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 19262551 Disease Relevance 0.35 Pain Relevance 0.31
Arc gene expression in the cortex was proportional to LFP amplitude in the spindle-range (10–14?
Gene_expression (expression) of Arc in cortex associated with aids-related complex
7) Confidence 0.76 Published 2007 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC2577304 Disease Relevance 0.17 Pain Relevance 0.25
Arc gene expression in the cortex showed correlation with LFP amplitude in the spindle-range (10–14?
Gene_expression (expression) of Arc in cortex associated with aids-related complex
8) Confidence 0.76 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.54 Pain Relevance 0.08
Indeed, IEG reinduction during REM sleep may explain the second wave of arc protein expression detected 8–24?
Gene_expression (expression) of arc protein associated with aids-related complex
9) Confidence 0.76 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.20 Pain Relevance 0
IEG upregulation after a few (Ribeiro et al., 1999, 2002) or many (Figure 4) sleep cycles is a plausible explanation for late waves of arc and zif-268 gene expression upregulation many hours after memory acquisition (Bekinschtein et al., 2007; Grimm and Tischmeyer, 1997).
Gene_expression (expression) of arc associated with aids-related complex
10) Confidence 0.76 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.10 Pain Relevance 0.03
These data indicate that mu opioid receptor activation contributes to METH-induced gene expression in the CPu and stereotypy, and that patch-enhanced PD and arc expression may be a homeostatic response to METH treatment.
Gene_expression (expression) of arc in CPu associated with aids-related complex and mu opioid receptor
11) Confidence 0.75 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20298714 Disease Relevance 0.40 Pain Relevance 0.19
Reactivity and plasticity in the amygdala nuclei during opiate withdrawal conditioning: differential expression of c-fos and arc immediate early genes.
Gene_expression (expression) of arc in amygdala associated with aids-related complex, opiate, withdrawal and amygdala
12) Confidence 0.75 Published 2008 Journal Neuroscience Section Title Doc Link 18501523 Disease Relevance 0.34 Pain Relevance 1.06
Sustained synthesis of Arc during a surprisingly protracted time-window is required for hyperphosphorylation of actin depolymerizing factor/cofilin and local expansion of the actin cytoskeleton in vivo.
Gene_expression (synthesis) of Arc associated with aids-related complex
13) Confidence 0.74 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.82 Pain Relevance 0.26
Double-labelling revealed that N/OFQ was present in some neurones located in the ventrolateral part of the Arc producing pro-opiomelanocortin, as shown by the presence of the anorexigenic peptides alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript and, occasionally, in single neurones of the ventrolateral Arc producing orexigenic agouti-related peptide, but not neuropeptide Y.
Gene_expression (producing) of Arc in melanocyte associated with aids-related complex, neuropeptide and cocaine
14) Confidence 0.74 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20025627 Disease Relevance 0.35 Pain Relevance 0.45
levels of Arc, ?
Gene_expression (levels) of Arc associated with aids-related complex
15) Confidence 0.71 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.71 Pain Relevance 0
expression of Arc, Narp, and Zif268 in the dentate gyrus after training rats in
Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex
16) Confidence 0.71 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.43 Pain Relevance 0.06
in C10, C60, L10, and L60 animals when compared with caged control (CC) animals

(Figure 2, P > .05), indicating that Arc expression in the dentate

Gene_expression (expression) of Arc associated with aids-related complex
17) Confidence 0.71 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.69 Pain Relevance 0
blades of the dentate gyrus, whereas Arc and Narp expression are selectively
Gene_expression (expression) of Arc in dentate gyrus associated with aids-related complex
18) Confidence 0.71 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.81 Pain Relevance 0
As

previously described, Arc-expressing cells were dispersed along both the dorsal

Gene_expression (expressing) of Arc in dorsal associated with aids-related complex
19) Confidence 0.71 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.83 Pain Relevance 0
Therefore, our findings reveal that actin rearrangements in the amygdala and the DH are required for the acquisition and consolidation of the aversive memories of drug withdrawal and that the beta-noradrenergic system within the amygdala modulates aversive memory consolidation by regulating actin rearrangements but not Arc protein expression in the DH, which is distinct from its role in modulation of inhibitory avoidance memory.
Gene_expression (expression) of Arc protein in amygdala associated with aids-related complex, hippocampus, withdrawal and amygdala
20) Confidence 0.71 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19793983 Disease Relevance 0.17 Pain Relevance 1.29

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