INT73322

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.35
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
trigeminal ganglion 2
dorsal root ganglia 2
neurons 1
nerve 1
inferior 1
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 35 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
inferior alveolar nerve 19 99.84 Very High Very High Very High
trigeminal ganglion 14 99.48 Very High Very High Very High
epidural 1 99.12 Very High Very High Very High
intrathecal 3 98.48 Very High Very High Very High
hyperexcitability 6 97.32 Very High Very High Very High
Action potential 3 97.30 Very High Very High Very High
allodynia 2 96.96 Very High Very High Very High
Trigeminal ganglion neurons 6 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 26 99.82 Very High Very High Very High
Ganglion Cysts 23 99.04 Very High Very High Very High
Neuropathic Pain 10 96.96 Very High Very High Very High
Injury 11 96.44 Very High Very High Very High
Hyperalgesia 3 93.44 High High
Nociception 10 89.92 High High
Dysesthesia 3 89.32 High High
Pain 5 81.32 Quite High
INFLAMMATION 8 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We here study the effect of chronic axotomy of the inferior alveolar nerve on the expression of SNS/PN3 mRNA in trigeminal sensory neurons.
Transcription (expression) of PN3 in inferior associated with inferior alveolar nerve
1) Confidence 0.69 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 0.94 Pain Relevance 0.86
We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.
Transcription (levels) of SCN10A in nerve associated with hyperalgesia and nervous system injury
2) Confidence 0.53 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9450690 Disease Relevance 0.36 Pain Relevance 0.14
The changes in the levels of SNS/PN3 mRNA in the trigeminal ganglion, which follow the time course for hyperexcitability of trigeminal ganglion neurons after inferior alveolar nerve injury, may contribute to the inappropriate firing associated with sensory dysfunction in the orofacial region.
Transcription (levels) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, trigeminal ganglion, hyperexcitability and trigeminal ganglion neurons
3) Confidence 0.52 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 0.98 Pain Relevance 0.71
Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat.
Transcription (Expression) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, trigeminal ganglion, neuropeptide and sodium channel
4) Confidence 0.52 Published 2000 Journal Exp. Neurol. Section Title Doc Link 10915577 Disease Relevance 0.83 Pain Relevance 0.88
A parallel restoration of the persistent hypernociception and up-regulation of Na(V)1.8 mRNA was observed after the cessation of ODN antisense treatment.
Transcription (observed) of Na(V)1.8
5) Confidence 0.52 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16043287 Disease Relevance 0.19 Pain Relevance 0.50
The siRNA, which was delivered to lumbar dorsal root ganglia (DRG) via an indwelling epidural cannula, caused a significant reduction of Na(V)1.8 mRNA expression in lumbar 4 and 5 (L4-L5) DRG neurons and consequently reversed mechanical allodynia in CCI rats.
Transcription (expression) of Na(V)1.8 in dorsal root ganglia associated with allodynia, injury and epidural
6) Confidence 0.52 Published 2007 Journal Neuroscience Section Abstract Doc Link 17367951 Disease Relevance 0.74 Pain Relevance 0.66
The local treatment with dipyrone abolished this persistent hypernociception but did not alter the Na(V)1.8 mRNA level in the DRG.
Transcription (level) of Na(V)1.8 in DRG
7) Confidence 0.52 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.49 Pain Relevance 0.31
TG neurons were classified into four types on the basis of their neurochemical and electrophysiological properties such as cell size, shapes of action potential (AP), isolectin-B(4) (IB(4)) binding, and were analyzed for the association of their distinctive electrophysiological properties and mRNA expression of Na(v)1.8 and TRPV1 by using single-cell RT-PCR following whole-cell recordings.
Transcription (expression) of Na(v)1.8 in neurons associated with action potential and trigeminal ganglion
8) Confidence 0.52 Published 2009 Journal Pain Section Abstract Doc Link 19376653 Disease Relevance 0.83 Pain Relevance 0.94

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