INT73323

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.77
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
DRG 3
trigeminal ganglion 2
neurons 2
nerve 1
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 55 100.00 Very High Very High Very High
tetrodotoxin 23 100.00 Very High Very High Very High
Trigeminal ganglion neurons 4 99.36 Very High Very High Very High
intrathecal 3 99.22 Very High Very High Very High
Root ganglion neuron 5 99.16 Very High Very High Very High
inferior alveolar nerve 12 99.04 Very High Very High Very High
allodynia 1 98.60 Very High Very High Very High
Sciatic nerve 2 97.88 Very High Very High Very High
trigeminal ganglion 6 95.76 Very High Very High Very High
Hyperalgesia 3 93.44 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 20 99.98 Very High Very High Very High
Injury 6 99.24 Very High Very High Very High
Ganglion Cysts 15 98.96 Very High Very High Very High
Diabetes Mellitus 9 98.64 Very High Very High Very High
Neuropathic Pain 11 98.60 Very High Very High Very High
Hyperalgesia 3 93.44 High High
Nociception 7 79.96 Quite High
INFLAMMATION 8 76.96 Quite High
Diabetic Neuropathy 6 75.00 Quite High
Pain 2 67.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia.
Negative_regulation (down-regulates) of SCN10A in dorsal root ganglia associated with nervous system injury
1) Confidence 0.58 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9450690 Disease Relevance 0.29 Pain Relevance 0.13
We show that SNS/PN3 mRNA is down-regulated in small-sized trigeminal ganglion neurons following inferior alveolar nerve injury but that, in contrast to the persistent loss of SNS/PN3 mRNA seen in dorsal root ganglion neurons following sciatic nerve injury, the levels of SNS/PN3 mRNA appear to normalize within a few weeks.
Negative_regulation (loss) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, root ganglion neuron, sciatic nerve and trigeminal ganglion neurons
2) Confidence 0.57 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 1.22 Pain Relevance 0.94
Our results show that, in rats with experimental diabetes, there is a significant upregulation of mRNA for the Na(v)1.3, Na(v)1.6, and Na(v)1.9 sodium channels and a downregulation of Na(v)1.8 mRNA 1 and 8 weeks after onset of allodynia.
Negative_regulation (downregulation) of Na(v)1.8 associated with allodynia, diabetes mellitus and sodium channel
3) Confidence 0.57 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12447933 Disease Relevance 1.06 Pain Relevance 1.08
Four daily intrathecal administrations of oligodeoxynucleotides (ODN) antisense against Na(V)1.8 decreased the mRNA encoding Na(V)1.8 in DRG.
Negative_regulation (decreased) of Na(V)1.8 in DRG associated with intrathecal
4) Confidence 0.57 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16043287 Disease Relevance 0.21 Pain Relevance 0.50
We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.
Negative_regulation (depress) of SCN10A in nerve associated with hyperalgesia and nervous system injury
5) Confidence 0.42 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9450690 Disease Relevance 0.36 Pain Relevance 0.14
Daily intrathecal administrations of antisense Na(V)1.8 decreased the Na(V)1.8 mRNA in the DRG and reduced ongoing persistent hypernociception.
Negative_regulation (decreased) of Na(V)1.8 in DRG associated with intrathecal
6) Confidence 0.42 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.52 Pain Relevance 0.32
Immunofluorescence studies showed significant increases in the levels and number of large DRG neurons from diabetic rats expressing Na(v)1.2, Na(v)1.3, Na(v)1.7, and Na(v)1.9 whereas Na(v)1.8 decreased.
Negative_regulation (decreased) of Na(v)1.8 in neurons associated with diabetes mellitus
7) Confidence 0.42 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16310161 Disease Relevance 0.64 Pain Relevance 0.29
With the exception of TTX, the potencies of a number of ion channel blockers for the Na(v)1.8, Na(v)1.2a, and Na(v)1.5 VGSC subtypes were similar.
Negative_regulation (number) of Na(v)1.8 associated with tetrodotoxin and sodium channel
8) Confidence 0.42 Published 2004 Journal Recept. Channels Section Abstract Doc Link 14769548 Disease Relevance 0 Pain Relevance 1.02
Ranolazine caused a preferential hyperpolarizing shift of the steady-state fast, intermediate and slow inactivation of hNa(V)1.7 and intermediate and slow inactivation of rNa(V)1.8, suggesting preferential interaction of the drug with the inactivated states of both channels.
Negative_regulation (inactivation) of Na(V)1.8
9) Confidence 0.42 Published 2008 Journal Channels (Austin) Section Abstract Doc Link 19077543 Disease Relevance 0.07 Pain Relevance 0.39
Because IB4 binding neurons differentiate from TrkA neurons in the postnatal period, the proportion of Na(v)1.8 cells that bind to IB4 increases, in parallel with a decrease in the proportion of Na(v)1.8-TrkA co-expressing cells.
Negative_regulation (decrease) of Na(v)1.8 in neurons
10) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11487631 Disease Relevance 0 Pain Relevance 0.69
We show that SNS/PN3 mRNA is down-regulated in small-sized trigeminal ganglion neurons following inferior alveolar nerve injury but that, in contrast to the persistent loss of SNS/PN3 mRNA seen in dorsal root ganglion neurons following sciatic nerve injury, the levels of SNS/PN3 mRNA appear to normalize within a few weeks.
Negative_regulation (down-regulated) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, root ganglion neuron, sciatic nerve and trigeminal ganglion neurons
11) Confidence 0.41 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 1.25 Pain Relevance 0.96
In contrast, the type II pyrethroids deltamethrin and fenvalerate evoked direct depolarization of Na(v)1.8-F-11 and Na(v)1.5-293-EBNA cells.
Negative_regulation (depolarization) of Na(v)1.8
12) Confidence 0.41 Published 2004 Journal Recept. Channels Section Abstract Doc Link 14769548 Disease Relevance 0 Pain Relevance 0.78
Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well as the Na(v)1.2 and Na(v)1.5 subtypes.
Negative_regulation (block) of PN3 associated with tetrodotoxin and sodium channel
13) Confidence 0.37 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18501613 Disease Relevance 0.16 Pain Relevance 0.60

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