INT73326

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna2d3)
Cacna2d3 (Mus musculus)
Pain Term Frequency Confidence Heat
Gabapentin 17 100.00 Very High Very High Very High
pregabalin 13 100.00 Very High Very High Very High
Antiepileptic agent 1 99.74 Very High Very High Very High
Calcium channel 10 98.80 Very High Very High Very High
Spinal cord 12 75.00 Quite High
spinal dorsal horn 4 53.20 Quite High
amygdala 12 48.64 Quite Low
Hippocampus 4 38.24 Quite Low
Glutamate 4 32.40 Quite Low
Pyramidal cell 4 28.56 Quite Low
Disease Term Frequency Confidence Heat
Urological Neuroanatomy 4 25.00 Low Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, there are two drugs on the market, gabapentin (Neurontin) and pregabalin (Lyrica), that are proposed to exert their therapeutic effect through binding to the alpha2-delta subunit of voltage-sensitive calcium channels.
Neurontin Binding (binding) of alpha2-delta associated with pregabalin, calcium channel and gabapentin
1) Confidence 0.27 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20571971 Disease Relevance 0 Pain Relevance 0.29
The novel antiepileptic agent gabapentin (Neurontin) binds with high affinity to the alpha 2 delta subunit of a voltage-dependent Ca2+ channel.
Neurontin Binding (affinity) of alpha 2 delta associated with antiepileptic agent and gabapentin
2) Confidence 0.12 Published 1998 Journal Anal. Biochem. Section Abstract Doc Link 9451509 Disease Relevance 0 Pain Relevance 0.29
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
Neurontin Binding (bind) of alpha2-delta associated with pregabalin and gabapentin
3) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.56
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
Neurontin Binding (bind) of alpha2-delta associated with pregabalin and gabapentin
4) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.56
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
Neurontin Binding (bind) of alpha2-delta associated with pregabalin and gabapentin
5) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.56
Of the four subtypes of alpha2-delta, only alpha2-delta types 1 and 2 (alpha2-delta-1 and alpha2-delta-2) bind the drugs gabapentin (Neurontin) and pregabalin (Lyrica).
Neurontin Binding (bind) of alpha2-delta associated with pregabalin and gabapentin
6) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18616987 Disease Relevance 0 Pain Relevance 0.56

General Comments

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