INT7333

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Context Info
Confidence 0.72
First Reported 1992
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.40
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CALM3) small molecule metabolic process (CALM3) carbohydrate metabolic process (CALM3)
cytoplasm (CALM3) cytosol (CALM3) signal transduction (CALM3)
Anatomy Link Frequency
SK-N-SH 1
CALM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 14 99.32 Very High Very High Very High
agonist 10 99.14 Very High Very High Very High
Morphine 3 97.76 Very High Very High Very High
Opioid 4 86.24 High High
addiction 1 82.72 Quite High
tolerance 1 82.12 Quite High
Analgesic 4 65.60 Quite High
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine pretreatment significantly enhanced basal G protein coupling of wild type MOR, which is thought to result from release of CaM.
Localization (release) of CaM associated with mu opioid receptor and morphine
1) Confidence 0.72 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457836 Disease Relevance 0 Pain Relevance 1.06
The CaM translocation with the combination of an agent that elevates cyclic AMP levels and a low dose of carbachol was not different from that observed with either agent alone.
Localization (translocation) of CaM
2) Confidence 0.63 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.07 Pain Relevance 0.19
The effect of agonist-stimulated second messenger production on CaM localization was determined by activating receptors that increase and decrease adenylyl cyclase activity on SK-N-SH cells.
Localization (localization) of CaM in SK-N-SH associated with agonist
3) Confidence 0.63 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.16 Pain Relevance 0.19
Activation of PPI hydrolysis by carbachol elicits a robust translocation of CaM from membranes into cytosol which was previously shown to be mimicked by the addition of the calcium ionophore ionomycin and the phorbol ester TPA28.
Localization (translocation) of CaM
4) Confidence 0.63 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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