INT73330

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.33
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB2) extracellular region (SERPINB2) Golgi apparatus (SERPINB2)
plasma membrane (SERPINB2) cytoplasm (SERPINB2)
Anatomy Link Frequency
endothelial cells 1
sciatic nerve 1
dorsal root ganglion 1
SERPINB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
neuralgia 4 100.00 Very High Very High Very High
cytokine 18 99.98 Very High Very High Very High
Inflammation 74 99.78 Very High Very High Very High
Root ganglion neuron 2 99.56 Very High Very High Very High
Sciatic nerve 2 99.12 Very High Very High Very High
Neuropathic pain 2 98.76 Very High Very High Very High
Peripheral nerve injury 2 98.44 Very High Very High Very High
abdominal pain 2 92.00 High High
agonist 29 91.40 High High
tolerance 1 90.52 High High
Disease Link Frequency Relevance Heat
Apoptosis 138 100.00 Very High Very High Very High
INFLAMMATION 88 99.78 Very High Very High Very High
Ganglion Cysts 2 99.36 Very High Very High Very High
Neuropathic Pain 2 98.76 Very High Very High Very High
Nervous System Injury 4 98.00 Very High Very High Very High
Thrombosis 5 97.88 Very High Very High Very High
Necrosis 5 97.78 Very High Very High Very High
Cancer 30 97.60 Very High Very High Very High
Papillomavirus Infection 1 94.48 High High
Cervical Cancer 1 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conservative systemic administration of antibiotics and urokinase is reported to be effective.
Positive_regulation (effective) of urokinase
1) Confidence 0.47 Published 1998 Journal Ann Vasc Surg Section Abstract Doc Link 9452003 Disease Relevance 0.67 Pain Relevance 0.14
In addition, SERPINB2, which represses pRb pro-apoptotic signal transduction [73], was induced in WTSTS cells.
Positive_regulation (induced) of SERPINB2 associated with apoptosis
2) Confidence 0.30 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.51 Pain Relevance 0
PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2) and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15).
Positive_regulation (activation) of SERPINB2
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2970545 Disease Relevance 0.66 Pain Relevance 0.32
Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury.
Positive_regulation (Induction) of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion associated with ganglion cysts, neuralgia, nervous system injury, root ganglion neuron and peripheral nerve injury
4) Confidence 0.17 Published 2005 Journal Neuroscience Section Title Doc Link 15780477 Disease Relevance 0.48 Pain Relevance 0.43
Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.
Spec (whether) Positive_regulation (induced) of plasminogen activator inhibitor-1 and -2 in sciatic nerve associated with sciatic nerve
5) Confidence 0.12 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.40 Pain Relevance 0.22
Inflammatory cytokines induce procoagulant molecules in endothelial cells such as von Willebrand factor, tissue factor and plasminogen activating inhibitor factors, PAI-1 and PAI-2.
Positive_regulation (induce) of PAI-2 in endothelial cells associated with inflammation and cytokine
6) Confidence 0.04 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.95 Pain Relevance 0.36
Postoperatively, however, tissue plasminogen activator (t-PA) activity is reduced and inflammatory cytokines (tumor necrosis factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6)) as well as plasminogen activator inhibitors (PAI-1, PAI-2) are elevated.
Positive_regulation (elevated) of PAI-2 associated with necrosis, inflammation, cancer and cytokine
7) Confidence 0.02 Published 2007 Journal BMC Surg Section Body Doc Link PMC1945018 Disease Relevance 1.67 Pain Relevance 0.10

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