INT73335

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2009
Negated 3
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 5.62
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (ACTB) cytosol (ACTB) cytoskeleton (ACTB)
protein complex (ACTB) cytoplasm (ACTB)
Anatomy Link Frequency
neuronal 1
fat 1
connective tissues 1
ACTB (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 84 98.96 Very High Very High Very High
Neuritis 1 91.44 High High
Nav1.7 7 88.88 High High
Inflammation 39 86.20 High High
member 8 54 85.76 High High
nav1.8 9 84.28 Quite High
cINOD 2 79.72 Quite High
Nav1.9 4 78.76 Quite High
Nav1.6 7 75.80 Quite High
COX2 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 94 98.96 Very High Very High Very High
Disease 69 98.56 Very High Very High Very High
Cancer 59 97.90 Very High Very High Very High
Familial Adenomatous Polyposis 104 97.18 Very High Very High Very High
Hepatocellular Cancer 51 93.60 High High
Peripheral Arterial Disease 17 92.00 High High
Neuritis 1 91.44 High High
Reprotox - General 3 11 86.56 High High
INFLAMMATION 41 86.20 High High
Neuropathic Pain 1 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One gene (ACTB) was consistently one of the two least stably expressed genes in both normal and OA fat and when comparing both groups of tissue.
Gene_expression (expressed) of ACTB in fat associated with osteoarthritis
1) Confidence 0.58 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.68 Pain Relevance 0.21
However, recent studies have shown that the expression stability of some of the commonly used reference genes, such as B2M, GAPDH and ACTB is not constant for all tissues or disease states [10,11].
Gene_expression (expression) of ACTB associated with disease
2) Confidence 0.58 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.19 Pain Relevance 0
The collagen embedded hUtSMCs demonstrated expression of the thrombin receptor F2R and the housekeeping gene, ACTB mRNA.
Gene_expression (expression) of ACTB
3) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Real time reverse transcriptase polymerase chain reaction (RT-PCR) assessed MPG expression and three reference genes namely; beta Actin (ACTB), Glyceraldehyde three phosphate dehydrogenase (GAPDH) and Ubiquitin c (UBC).
Gene_expression (expression) of ACTB
4) Confidence 0.56 Published 2009 Journal J. Photochem. Photobiol. B, Biol. Section Body Doc Link 19101162 Disease Relevance 0 Pain Relevance 0
4, 217 bp), and of the reference gene ACTB (362 bp) were also detected (Fig. 1, not shown for ACTB).
Neg (not) Gene_expression (detected) of ACTB
5) Confidence 0.52 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0.78
The mean ACTB normalised RNA quantities for treated and control ± SEM, for F2R were 0.215 ± 0.025, 0.09083 ± 0.01282, this is graphically represented in Figure 3C), with a resultant relative fold increase of 2.36 in the thrombin treated versus the untreated collagen gels.


Gene_expression (normalised) of ACTB
6) Confidence 0.50 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
The geNorm algorithm is employed to investigate the expression stability of 9 commonly used reference genes (glyceraldehyde-3-phosphate dehydrogenase [GAPDH], beta-actin [ACTB], beta-2-microglobulin [B2M] hydroxymethylbilane synthase [HMBS], hypoxanthine guanine phosphoribosyl transferase [HPRT], ribosomal protein L13a [RPL13A], succinate dehydrogenase flavoprotein subunit A [SDHA], TATA box binding protein [TBP] and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [YWHAZ]) [11] in normal and diseased canine connective tissues.
Gene_expression (expression) of ACTB in connective tissues
7) Confidence 0.45 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.67 Pain Relevance 0.22
Therefore, the present study aimed to determine the expression stability of common reference genes (ACTB, Beta actin; GAPDH, Glyceraldehyde-3-phosphate; B2M, Beta-2-microglobulin; HPRT1, Hypoxanthine phosphoribosyl-transferase I; SDHA, Succinate dehydrogenase complex, subunit A; YWHAZ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) under the influence of glucosamine, curcumin and diacerein in the IL-1?
Spec (determine) Gene_expression (expression) of ACTB
8) Confidence 0.42 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1820791 Disease Relevance 0.08 Pain Relevance 0.04
Biochemical characterization by western blotting revealed that 1 and 5 mM concentrations of TOCP significantly inhibited the expression of neurofilament high molecular weight protein (NF-H), and that 5 mM TOCP inhibited expression of microtubule-associated protein 2c and tau protein, but not beta-actin.
Gene_expression (expression) of beta-actin
9) Confidence 0.23 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16909309 Disease Relevance 0.33 Pain Relevance 0.09
Using Northern and RT-PCR analysis, we have determined in 15 control and 10 sporadic AD human neocortical samples (age range, 60-82 yr; postmortem interval [PMI] range, 0.7-16.0 hr) the levels of COX-2 RNA in relation to the constitutively expressed COX-1 and beta-actin RNA message levels.
Gene_expression (expressed) of beta-actin associated with disease
10) Confidence 0.20 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9452008 Disease Relevance 0.65 Pain Relevance 0.19
Placental beta-Actin expression was chosen as a control protein.
Gene_expression (expression) of beta-Actin
11) Confidence 0.02 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1184098 Disease Relevance 0.38 Pain Relevance 0
Survival related gene, Voltage dependent anion channel (Vdac1) and ubiquitin related gene, ubiquitin B (Ubb) and genes involved in localized neuronal translation, cytoplasmic beta-actin (Actb), eukaryotic elongation factor2 (Eef2) and eukaryotic elongation factor 1 (Eef1alpha 1); retrograde transport, p25 subunit of dynactin (Dctn5), were amongst the genes that showed significant upregulation in 59Q transfected cells as compared to internally normalized expression levels in vector transfected controls (Fig. 1).
Gene_expression (expression) of beta-actin in neuronal
12) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.35 Pain Relevance 0
The levels of APC expression in cancer and non-cancer tissues (the order of the patients is identical to the panel above) were standardized to the respective beta-actin expression levels.
Gene_expression (expression) of beta-actin associated with cancer and familial adenomatous polyposis
13) Confidence 0.02 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.93 Pain Relevance 0.04
Our study is in agreement with the previous report that PPIase, beta-actin and GAPDH are maintenance genes expressed in 11 human adult and fetal tissues but are not expressed at the same level in these tissues [17].
Gene_expression (expressed) of beta-actin
14) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
In addition, we report previously postulated housekeeping genes such as peptidyl-prolyl cis-trans isomerase A, glyceraldehyde-3-phosphate dehydrogenase and beta-actin, which are expressed in all the tissues, but with significant difference in their expression levels.
Gene_expression (expressed) of beta-actin
15) Confidence 0.01 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
According to the current study, the ubiquitous genes also previously called housekeeping genes such as PPIase, GAPDH, and beta-actin are expressed in all tissues with significant difference in their expression levels.
Gene_expression (expressed) of beta-actin
16) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.08 Pain Relevance 0.08
The results have also shown that, the previously postulated housekeeping genes namely peptidyl-prolyl cis-trans isomerase A (PPIase), GAPDH, beta-actin are not constantly expressed in all the tissues.


Neg (not) Gene_expression (expressed) of beta-actin
17) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.21 Pain Relevance 0.10
Beta-actin was also differentially expressed between the tissues.
Gene_expression (expressed) of Beta-actin
18) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
In addition, we report previously postulated housekeeping genes such as peptidyl-prolyl cis-trans isomerase A, glyceraldehyde-3-phosphate dehydrogenase and beta-actin, which are expressed in all the tissues, but with significant difference in their expression levels.
Gene_expression (expression) of beta-actin
19) Confidence 0.01 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC1888706 Disease Relevance 0 Pain Relevance 0
According to the current study, the ubiquitous genes also previously called housekeeping genes such as PPIase, GAPDH, and beta-actin are expressed in all tissues with significant difference in their expression levels.
Gene_expression (expression) of beta-actin
20) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.08 Pain Relevance 0.14

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