INT73338

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 6.72
Pain Relevance 10.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
foot 2
retina 1
tail 1
knee joint 1
brain 1
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 18 100.00 Very High Very High Very High
Periaqueductal grey 32 99.98 Very High Very High Very High
analgesia 42 99.96 Very High Very High Very High
IPN 1 99.76 Very High Very High Very High
Analgesic 24 99.68 Very High Very High Very High
Cannabinoid 24 99.68 Very High Very High Very High
Endocannabinoid 77 99.52 Very High Very High Very High
Potency 2 99.28 Very High Very High Very High
Cannabinoid receptor 22 99.04 Very High Very High Very High
alcohol 6 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 100.00 Very High Very High Very High
Urological Neuroanatomy 38 99.98 Very High Very High Very High
Inflammatory Pain 9 99.76 Very High Very High Very High
Injury 7 98.36 Very High Very High Very High
Shock 4 98.20 Very High Very High Very High
Granulomatous Inflammation 5 97.42 Very High Very High Very High
Pain 53 97.32 Very High Very High Very High
INFLAMMATION 28 97.20 Very High Very High Very High
Nociception 19 96.72 Very High Very High Very High
Anxiety Disorder 7 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The piperidine/piperazine urea may thus represent a privileged chemical scaffold for the synthesis of FAAH inhibitors that display an unprecedented combination of potency and selectivity for use as potential analgesic and anxiolytic/antidepressant agents.
Gene_expression (synthesis) of FAAH associated with antidepressant, analgesic, anxiety disorder and potency
1) Confidence 0.77 Published 2007 Journal Biochemistry Section Abstract Doc Link 17949010 Disease Relevance 0.15 Pain Relevance 0.22
FAAH-IR was also present in small, NF200-negative cultured rat DRG neurons.
Gene_expression (present) of FAAH-IR in neurons associated with dorsal root ganglion
2) Confidence 0.77 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 1.23 Pain Relevance 0.87
We found that cannabinoids receptors (CB1 and CB2), FAAH and TRPV1 were expressed in chorio-allantoic placenta.
Gene_expression (expressed) of FAAH in placenta associated with cannabinoid
3) Confidence 0.75 Published 2008 Journal Placenta Section Abstract Doc Link 18561998 Disease Relevance 0 Pain Relevance 0.33
CONCLUSIONS: The original observation that retinal ischemia-reperfusion reduces endogenous AEA via enhanced expression of FAAH supports the deduction that this is implicated in retinal cell loss caused by high IOP in the RGC layer.


Gene_expression (expression) of FAAH in RGC
4) Confidence 0.72 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
RESULTS: In rat retina, ischemic insult followed by reperfusion resulted in enhanced FAAH activity and protein expression paralleled by a significant decrease in the endogenous AEA tone, whereas the AEA-membrane transporter or the AEA-synthase NAPE-PLD (N-acyl-phosphatidylethanolamine-hydrolyzing-phospholipase-d) were not affected.
Gene_expression (expression) of FAAH in retina
5) Confidence 0.72 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
The results suggest that an approach balancing inhibitor reactivity with target recognition produces FAAH inhibitors that display significantly improved drug-likeness.
Gene_expression (produces) of FAAH
6) Confidence 0.68 Published 2009 Journal ChemMedChem Section Abstract Doc Link 19637155 Disease Relevance 0.15 Pain Relevance 0.13
A single 2.5-kb FAAH mRNA is distributed throughout the rat CNS and accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postnatal day 30, then decreases into adulthood.
Gene_expression (distributed) of FAAH mRNA
7) Confidence 0.68 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9452020 Disease Relevance 0 Pain Relevance 0.07
An ipsilateral versus contralateral increase in both the size and proportion of FAAH-IR DRG occurred after spinal nerve transection injury but not after chronic inflammation of the rat hindpaw 2 d after injection of complete Freund's adjuvant.
Gene_expression (proportion) of FAAH-IR DRG in DRG associated with dorsal root ganglion, inflammation and injury
8) Confidence 0.67 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 1.21 Pain Relevance 0.73
Interestingly, oleamide analogs resistant to hydrolysis by fatty acid amide hydrolase (FAAH) maintained but did not show increased behavioral potency or duration of action, whereas two FAAH inhibitors produced analogous behavioral effects.
Gene_expression (produced) of FAAH associated with potency
9) Confidence 0.67 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11561096 Disease Relevance 0.40 Pain Relevance 1.00
Granuloma formation was accompanied by a significant decrease in endocannabinoid and palmitoylethanolamide levels paralleled by increased levels of the fatty acid amide hydrolase, responsible for their breakdown.
Gene_expression (levels) of fatty acid amide hydrolase associated with endocannabinoid and granulomatous inflammation
10) Confidence 0.66 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19931394 Disease Relevance 0.85 Pain Relevance 0.55
Notably, 2-AG accumulation was of smaller magnitude than that observed previously in the dorsal midbrain following foot shock. 2-AG is preferentially degraded by monoacylglycerol lipase (MGL), whereas anandamide is hydrolyzed primarily by fatty-acid amide hydrolase (FAAH).
Gene_expression (hydrolyzed) of fatty-acid amide hydrolase in foot associated with shock and midbrain
11) Confidence 0.64 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16316669 Disease Relevance 0.53 Pain Relevance 1.36
Notably, 2-AG accumulation was of smaller magnitude than that observed previously in the dorsal midbrain following foot shock. 2-AG is preferentially degraded by monoacylglycerol lipase (MGL), whereas anandamide is hydrolyzed primarily by fatty-acid amide hydrolase (FAAH).
Gene_expression (hydrolyzed) of FAAH in foot associated with shock and midbrain
12) Confidence 0.64 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16316669 Disease Relevance 0.54 Pain Relevance 1.36
A decreased expression of fatty acid amidohydrolase (FAAH), the main endocannabinoid-degrading enzyme, was found in prefrontal cortex (PFC) of AA rats, and was accompanied by decreased enzyme activity in this region.
Gene_expression (expression) of FAAH in PFC associated with endocannabinoid
13) Confidence 0.63 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482090 Disease Relevance 0 Pain Relevance 0.59
The biosynthesis of NAGly and its degradation by the enzyme fatty acid amide hydrolase can be observed in rat brain tissue.
Gene_expression (biosynthesis) of fatty acid amide hydrolase in brain
14) Confidence 0.62 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11518719 Disease Relevance 0.26 Pain Relevance 0.33
The synthesis and evaluation for their FAAH inhibitory activities of a series of 18 paracetamol esters are described.
Gene_expression (synthesis) of FAAH associated with paracetamol
15) Confidence 0.59 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20143779 Disease Relevance 0.06 Pain Relevance 0.22
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
Gene_expression (profile) of FAAH associated with analgesic
16) Confidence 0.59 Published 2006 Journal CNS Drug Rev Section Title Doc Link 16834756 Disease Relevance 0.22 Pain Relevance 0.42
These findings suggest the vasodilator action of anandamide in the rat knee joint involved hydrolysis of the compound by FAAH, production of COX-derived eicosanoid(s), activation of TRPV1 receptors, and a small component involved activation of endothelial anandamide/abnormal-cannabidiol receptors; a minor delayed dilator response was mediated by activation of conventional cannabinoid receptors.
Gene_expression (production) of FAAH in knee joint associated with cannabinoid receptor
17) Confidence 0.56 Published 2007 Journal Life Sci. Section Abstract Doc Link 17275857 Disease Relevance 0 Pain Relevance 0.32
The cannabinergic proteins currently being explored, which include the CB1 and CB2 receptors, FAAH and the anandamide transporter, are excellent targets for the development of therapeutically useful drugs for a range of conditions including pain, loss of appetite, immunosuppression, peripheral vascular disease and motor disorders.
Gene_expression (include) of FAAH associated with pain, anorexia and increased venous pressure under development
18) Confidence 0.47 Published 2002 Journal Chem. Phys. Lipids Section Abstract Doc Link 12505686 Disease Relevance 0.28 Pain Relevance 0.31
Recently, Boger and co-workers reported a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of FAAH that produce analgesia in animal models (J.
Gene_expression (produce) of FAAH associated with analgesia
19) Confidence 0.42 Published 2005 Journal J. Am. Chem. Soc. Section Abstract Doc Link 16332087 Disease Relevance 0 Pain Relevance 0.19
Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development

Background

Gene_expression (expression) of anandamide-binding associated with endocannabinoid
20) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Title Doc Link PMC2775033 Disease Relevance 0 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox