INT73339

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.47
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
dorsal root ganglion 2
neuronal 1
sciatic nerve 1
spinal cord 1
neurons 1
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 15 100.00 Very High Very High Very High
Endocannabinoid 15 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
dorsal root ganglion 45 99.68 Very High Very High Very High
Spinal cord 5 99.32 Very High Very High Very High
Sciatic nerve 10 99.24 Very High Very High Very High
Peripheral nerve injury 5 97.60 Very High Very High Very High
amygdala 1 90.32 High High
IPN 1 88.72 High High
Cannabinoid 5 88.64 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 45 99.44 Very High Very High Very High
Nervous System Injury 5 97.16 Very High Very High Very High
Pain 5 95.80 Very High Very High Very High
Hypersensitivity 5 95.20 Very High Very High Very High
Nociception 10 78.08 Quite High
Injury 10 42.80 Quite Low
INFLAMMATION 5 30.32 Quite Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activity-based protein profiling (ABPP) revealed that these urea inhibitors were completely selective for FAAH relative to other mammalian serine hydrolases.
Localization (selective) of FAAH
1) Confidence 0.75 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19386497 Disease Relevance 0 Pain Relevance 0.09
In situ hybridization revealed profound distribution of FAAH mRNA in neuronal cells throughout the CNS.
Localization (distribution) of FAAH mRNA in neuronal
2) Confidence 0.75 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9452020 Disease Relevance 0 Pain Relevance 0.16
In naive rats, FAAH immunoreactivity localized to the soma of 32.7 +/- 0.8% of neurons in L4 and L5 DRG.
Localization (localized) of FAAH in neurons associated with dorsal root ganglion
3) Confidence 0.70 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.92 Pain Relevance 0.79
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.
Localization (Localization) of fatty acid amide hydrolase in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, endocannabinoid, nervous system injury and peripheral nerve injury
4) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Title Doc Link 19321773 Disease Relevance 0.83 Pain Relevance 0.94
Using immunohistochemistry, Western blotting, and reverse transcription-PCR, we demonstrate the location of the FAAH in adult rat DRG, sciatic nerve, and spinal cord.
Localization (location) of FAAH in sciatic nerve associated with dorsal root ganglion, sciatic nerve and spinal cord
5) Confidence 0.65 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.91 Pain Relevance 0.75
Using immunohistochemistry, Western blotting, and reverse transcription-PCR, we demonstrate the location of the FAAH in adult rat DRG, sciatic nerve, and spinal cord.
Localization (location) of FAAH in DRG associated with dorsal root ganglion, sciatic nerve and spinal cord
6) Confidence 0.22 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.91 Pain Relevance 0.75
Using immunohistochemistry, Western blotting, and reverse transcription-PCR, we demonstrate the location of the FAAH in adult rat DRG, sciatic nerve, and spinal cord.
Localization (location) of FAAH in spinal cord associated with dorsal root ganglion, sciatic nerve and spinal cord
7) Confidence 0.22 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.91 Pain Relevance 0.75

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