INT73340

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 134
Total Number 143
Disease Relevance 38.67
Pain Relevance 85.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
brain 4
medulla 3
tail 2
BLA 2
spinal 2
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 406 100.00 Very High Very High Very High
Endocannabinoid 366 100.00 Very High Very High Very High
Cannabinoid 244 100.00 Very High Very High Very High
COX2 18 100.00 Very High Very High Very High
cINOD 45 99.98 Very High Very High Very High
Serotonin 26 99.92 Very High Very High Very High
Gabapentin 4 99.92 Very High Very High Very High
Analgesic 188 99.88 Very High Very High Very High
Nicotine 36 99.84 Very High Very High Very High
Central grey 100 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 157 100.00 Very High Very High Very High
INFLAMMATION 214 99.86 Very High Very High Very High
Urological Neuroanatomy 367 99.82 Very High Very High Very High
Neuropathic Pain 315 99.72 Very High Very High Very High
Hyperalgesia 217 99.60 Very High Very High Very High
Pain 401 99.30 Very High Very High Very High
Ganglion Cysts 16 99.24 Very High Very High Very High
Stress 47 99.12 Very High Very High Very High
Metabolic Disorder 2 99.08 Very High Very High Very High
Diabetes Mellitus 9 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitors) of fatty acid amide hydrolase
1) Confidence 0.59 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17459705 Disease Relevance 0.15 Pain Relevance 0.34
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitors) of FAAH
2) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19386497 Disease Relevance 0 Pain Relevance 0.08
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitors) of fatty acid amide hydrolase associated with pain
3) Confidence 0.59 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 18289847 Disease Relevance 0 Pain Relevance 0.37
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitors) of fatty acid amide hydrolase
4) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19386497 Disease Relevance 0 Pain Relevance 0.08
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Negative_regulation (inhibitors) of FAAH associated with pain
5) Confidence 0.59 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 18289847 Disease Relevance 0 Pain Relevance 0.37
The compound was also able to inhibit the FAAH activity in rat basophilic leukemia cells as assessed by measuring either the hydrolysis of anandamide, the FAAH-dependent cellular accumulation of anandamide, or the FAAH-dependent recycling of tritium to the cell membranes.
Negative_regulation (inhibit) of FAAH associated with leukemia
6) Confidence 0.59 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20143779 Disease Relevance 0.10 Pain Relevance 0.24
The compound inhibited FAAH activity in a competitive manner with a K(i) value of 0.16 microM.
Negative_regulation (inhibited) of FAAH
7) Confidence 0.59 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20143779 Disease Relevance 0.09 Pain Relevance 0.24
In order to determinate the physiological properties of the FAAH inhibition on the sleep modulation, we report the pharmacological effects on the sleep-wake cycle of the rat after i.c.v. administrations of URB597, oleoylethanolamide or palmitoylethanolamide (10, 20 microg/5 microl).
Negative_regulation (inhibition) of FAAH
8) Confidence 0.59 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17336288 Disease Relevance 0 Pain Relevance 0.20
These findings indicate that that inhibition of the FAAH, via URB597, modulates waking.
Negative_regulation (inhibition) of FAAH
9) Confidence 0.59 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17336288 Disease Relevance 0.06 Pain Relevance 0.22
It was also observed, using cell membrane preparations, that it inhibits the hydrolytic activity of fatty acid amide hydrolase (FAAH) on anandamide (N-arachidonylethanolamide).
Negative_regulation (inhibits) of fatty acid amide hydrolase
10) Confidence 0.59 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12234618 Disease Relevance 0.10 Pain Relevance 0.14
It was also observed, using cell membrane preparations, that it inhibits the hydrolytic activity of fatty acid amide hydrolase (FAAH) on anandamide (N-arachidonylethanolamide).
Negative_regulation (inhibits) of FAAH
11) Confidence 0.59 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12234618 Disease Relevance 0.10 Pain Relevance 0.14
Rather unexpectedly based on the high chemical stability of the urea functional group, PF-750 and PF-622 were found to inhibit FAAH in a time-dependent manner by covalently modifying the enzyme's active site serine nucleophile.
Negative_regulation (inhibit) of FAAH
12) Confidence 0.58 Published 2007 Journal Biochemistry Section Abstract Doc Link 17949010 Disease Relevance 0.36 Pain Relevance 0.38
Inhibition of FAAH activity increases AEA concentrations in nervous tissue and reduces sensory hypersensitivity in animal pain models.
Negative_regulation (Inhibition) of FAAH in nervous tissue associated with pain and hypersensitivity
13) Confidence 0.58 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 0.79 Pain Relevance 0.67
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Negative_regulation (inhibitors) of fatty acid amide hydrolase associated with endocannabinoid, ipn and analgesic
14) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.44 Pain Relevance 0.81
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Negative_regulation (inhibitors) of FAAH associated with endocannabinoid, ipn and analgesic
15) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.44 Pain Relevance 0.82
The aim of this study was to determine whether local inhibition of FAAH alters nociceptive responses of spinal neurons in the spinal nerve ligation model of neuropathic pain.
Spec (whether) Negative_regulation (inhibition) of FAAH in spinal nerve associated with nociception, spinal nerve ligature and neuropathic pain
16) Confidence 0.58 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17182782 Disease Relevance 0.46 Pain Relevance 0.89
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.
Negative_regulation (inhibition) of fatty acid amide hydrolase in nucleus accumbens associated with nucleus accumbens, dopamine and cannabinoid
17) Confidence 0.57 Published 2006 Journal J. Neurochem. Section Title Doc Link 16805835 Disease Relevance 0 Pain Relevance 0.55
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats.
Negative_regulation (inhibition) of FAAH in nucleus accumbens associated with nucleus accumbens, dopamine and cannabinoid
18) Confidence 0.57 Published 2006 Journal J. Neurochem. Section Title Doc Link 16805835 Disease Relevance 0 Pain Relevance 0.55
Inhibitors of FAAH are considered a potential therapeutic approach for the treatment of several nervous system disorders, including pain, anxiety, and insomnia.
Negative_regulation (Inhibitors) of FAAH in nervous system associated with pain, neurological disease, anxiety disorder and sleep disorders
19) Confidence 0.57 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15229230 Disease Relevance 0.38 Pain Relevance 0.26
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity.
Negative_regulation (inhibitors) of fatty acid amide hydrolase associated with potency and analgesia
20) Confidence 0.57 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15229230 Disease Relevance 0.33 Pain Relevance 0.30

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