INT7335

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.28
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CALM3) small molecule metabolic process (CALM3) carbohydrate metabolic process (CALM3)
cytoplasm (CALM3) cytosol (CALM3) signal transduction (CALM3)
Anatomy Link Frequency
lobe 2
SH-SY5Y 1
CALM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 97.12 Very High Very High Very High
Morphine 1 94.48 High High
agonist 13 94.08 High High
opiate 1 93.72 High High
antagonist 2 91.96 High High
Opioid 2 87.88 High High
Calcium channel 18 70.32 Quite High
adenocard 3 62.04 Quite High
Neurotransmitter 8 48.00 Quite Low
TRP channel 8 45.04 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 5 75.00 Quite High
Cognitive Disorder 94 50.00 Quite Low
Aging 6 9.48 Low Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Schizophrenia 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UK 14,304, DPDPE and DAMGO potentiated carbachol-stimulated increases in cytosolic CaM.
Positive_regulation (increases) of CaM
1) Confidence 0.36 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.07 Pain Relevance 0.14
Incubation of cells with vasoactive intestinal polypeptide (VIP), dibutyryl cyclic AMP and forskolin, resulted in 30% decrease in membrane CaM and an increase in cytosolic CaM of 40-50%.
Positive_regulation (increase) of CaM
2) Confidence 0.36 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.13 Pain Relevance 0.19
In addition, cAMP formation in SH-SY5Y cell membranes was significantly increased in the presence of Ca2+ (1.46 microM), CaM (200 nM) and forskolin (1 microM).
Positive_regulation (increased) of CaM in SH-SY5Y
3) Confidence 0.32 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.36
CaM mutants with a dysfunctional C lobe (CaM34, CaM1234) had no effect (Fig. 1F), probably because these mutants do not interact with the TRPV4 C-terminal domain and do not functionally compete with endogenous CaM.
Positive_regulation (dysfunctional) of CaM34 in lobe
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.03
Ethanolamine (1M, pH8.5) was injected for 7 min to block the remaining activated groups. 5 ┬ÁM CaM (Sigma, St.
Positive_regulation (activated) of CaM
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0
CaM mutants with a dysfunctional C lobe (CaM34, CaM1234) had no effect (Fig. 1F), probably because these mutants do not interact with the TRPV4 C-terminal domain and do not functionally compete with endogenous CaM.
Neg (not) Positive_regulation (dysfunctional) of CaM1234 in lobe
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.03
This so-called Ca2+/CaM complex activates Ca2+/CaM protein kinase (CaMK), which can activate calcium-dependent protein kinase (PKC) as well, but also PKA.
Positive_regulation (activates) of CaM
7) Confidence 0.02 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03

General Comments

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