INT73351

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 5.71
Pain Relevance 14.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
skin 2
brain 1
dopamine neurons 1
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 101 100.00 Very High Very High Very High
analgesia 8 100.00 Very High Very High Very High
Analgesic 7 100.00 Very High Very High Very High
Opioid 15 99.96 Very High Very High Very High
narcan 4 99.84 Very High Very High Very High
allodynia 21 99.78 Very High Very High Very High
Morphine 13 99.62 Very High Very High Very High
addiction 7 99.60 Very High Very High Very High
Pain 14 99.56 Very High Very High Very High
Substantia nigra 7 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 8 100.00 Very High Very High Very High
Neuropathic Pain 21 99.78 Very High Very High Very High
Post Operative Pain 2 99.60 Very High Very High Very High
Pain 11 99.56 Very High Very High Very High
Herpes Simplex Virus Infection 10 98.16 Very High Very High Very High
Injury 1 97.72 Very High Very High Very High
Parkinson's Disease 2 96.32 Very High Very High Very High
Targeted Disruption 6 95.28 Very High Very High Very High
Hyperalgesia 4 94.76 High High
Nociception 8 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene.
Negative_regulation (lacking) of nociceptin associated with orphanin, tolerance, analgesia and morphine
1) Confidence 0.42 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9453234 Disease Relevance 0 Pain Relevance 1.37
The action of nociceptin was inhibited by the leukotriene B(4) receptor antagonist ONO-4057 and azelastine, which inhibits the action and production of leukotriene B(4) in the skin.
Negative_regulation (inhibited) of nociceptin in skin associated with antagonist and orphanin
2) Confidence 0.42 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191560 Disease Relevance 0.24 Pain Relevance 0.66
Finally, deletion of the N/OFQ gene conferred mice partial protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced loss of SN dopamine neurons.
Negative_regulation (deletion) of N/OFQ in dopamine neurons associated with dopamine and substantia nigra
3) Confidence 0.42 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16237164 Disease Relevance 0.55 Pain Relevance 0.82
On the other hand, intrathecal injection of low dose nociceptin/orphanin FQ produces allodynia, but high dose of nociceptin/orphanin FQ produces an analgesic effect.
Negative_regulation (dose) of orphanin FQ associated with allodynia, analgesic, orphanin and intrathecal
4) Confidence 0.41 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10215100 Disease Relevance 0.54 Pain Relevance 1.88
In conclusion, these results, obtained using a combined pharmacological and genetic approach, indicate that blockade of the N/OFQ-NOP receptor signalling in the brain produces antidepressant-like effects in the mouse FST.
Negative_regulation (blockade) of N/OFQ in brain associated with antidepressant
5) Confidence 0.41 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12752799 Disease Relevance 0.51 Pain Relevance 0.48
Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Negative_regulation (blocks) of nociceptin associated with pain and orphanin
6) Confidence 0.38 Published 1998 Journal Nature Section Title Doc Link 9521323 Disease Relevance 1.09 Pain Relevance 1.60
OFQ inhibition of colonic propulsion was unaffected by coadministration of the competitive opioid receptor antagonist naltrexone.
Negative_regulation (inhibition) of OFQ associated with antagonist and opioid receptor
7) Confidence 0.38 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 9886987 Disease Relevance 0 Pain Relevance 0.62
Supraspinal OFQ2 analgesia was readily reversed by naloxone, implying that it activated opioid systems.
Negative_regulation (reversed) of OFQ2 associated with narcan, opioid and analgesia
8) Confidence 0.38 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601687 Disease Relevance 0 Pain Relevance 1.07
Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism.
Negative_regulation (impairment) of nociceptin associated with cognitive disorder, orphanin and opioid
9) Confidence 0.38 Published 2010 Journal Neurobiol Learn Mem Section Title Doc Link 20026233 Disease Relevance 0.37 Pain Relevance 0.68
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Negative_regulation (deficiency) of Nociceptin associated with pain, post operative pain, orphanin and herpes simplex virus infection
10) Confidence 0.35 Published 2008 Journal Neuroreport Section Title Doc Link 18281898 Disease Relevance 0.97 Pain Relevance 1.22
Although nociceptin-receptor deficiency did not affect the development of skin lesions and herpetic allodynia, it prevented postherpetic allodynia.
Negative_regulation (deficiency) of nociceptin in skin associated with allodynia, orphanin and herpes simplex virus infection
11) Confidence 0.35 Published 2008 Journal Neuroreport Section Abstract Doc Link 18281898 Disease Relevance 0.92 Pain Relevance 0.94
Pretreatment with a histamine antiserum or a histidine decarboxylase inhibitor resulted in a significant reduction of the response to nociceptin.
Negative_regulation (reduction) of nociceptin associated with orphanin
12) Confidence 0.28 Published 2004 Journal Pain Section Abstract Doc Link 15494198 Disease Relevance 0.47 Pain Relevance 1.01
In mice lacking nociceptin/orphanin FQ receptor (NOP), or the NMDA receptor epsilon1 subunit, both of which mediate anti-opioid activities, analgesic tolerance and dependence following chronic morphine treatments were markedly attenuated.
Negative_regulation (lacking) of nociceptin associated with addiction, analgesic, nmda receptor, orphanin, tolerance, opioid and morphine
13) Confidence 0.11 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469049 Disease Relevance 0.06 Pain Relevance 1.83

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