INT73354

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 36
Total Number 39
Disease Relevance 13.74
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gap43) plasma membrane (Gap43)
Anatomy Link Frequency
brain 5
LGN 5
optic nerve 4
neuronal 3
growth cone 3
Gap43 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 9 100.00 Very High Very High Very High
Neuropeptide 3 99.98 Very High Very High Very High
imagery 263 99.80 Very High Very High Very High
Sciatic nerve 142 99.64 Very High Very High Very High
Calcitonin gene-related peptide 10 99.64 Very High Very High Very High
Spinal cord 83 99.24 Very High Very High Very High
gABA 19 99.14 Very High Very High Very High
unmyelinated 2 99.12 Very High Very High Very High
Thalamus 45 98.00 Very High Very High Very High
Hippocampus 75 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 126 100.00 Very High Very High Very High
Stroke 322 99.84 Very High Very High Very High
Injury 257 99.76 Very High Very High Very High
Nociception 7 98.76 Very High Very High Very High
Neurologic Manifestations 8 97.20 Very High Very High Very High
Adhesions 18 93.60 High High
Targeted Disruption 149 93.16 High High
Ganglion Cysts 102 92.16 High High
Intellectual Impairment 8 91.84 High High
Neuritis 2 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of growth-associated molecules, in particular the growth-associated protein GAP-43, by the sprouting nerve fibers appears to be an important determinant of the sprouting response.
Gene_expression (expression) of GAP-43 in nerve
1) Confidence 0.77 Published 1997 Journal Anat. Embryol. Section Abstract Doc Link 9453362 Disease Relevance 0 Pain Relevance 0.25
Finally, in sections of injured sciatic nerves, we analyzed the expression of Cdc2 and GAP-43 proteins that are both up-regulated during peripheral regenerative processes.
Spec (analyzed) Gene_expression (expression) of GAP-43 in sciatic nerves associated with sciatic nerve
2) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 20347016 Disease Relevance 0.71 Pain Relevance 0.66
Expression of GAP-43 stained with green fluorescence in Figure 2A,B indicates regeneration of axon of optic nerve.
Gene_expression (Expression) of GAP-43 in optic nerve
3) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.21 Pain Relevance 0
The expressed GAP-43 is located in the growth cone of the regenerating axon.
Gene_expression (expressed) of GAP-43 in growth cone
4) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.27 Pain Relevance 0
Axon of positive GAP-43 expression distributes along the longitudinal axis of optic nerve.
Gene_expression (expression) of GAP-43 in optic nerve
5) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.17 Pain Relevance 0
GAP-43 expression of optic nerve increased significantly with the survival time.
Gene_expression (expression) of GAP-43 in optic nerve
6) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.17 Pain Relevance 0
In both cases, we infer that the fiber tracts connecting to or crossing the IL striatum may be the anatomical basis of the histological changes in GAP 43 expression observed in the stroke brains.
Gene_expression (expression) of GAP 43 in brains associated with stroke
7) Confidence 0.69 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.48 Pain Relevance 0.28
Interestingly, we found that GAP 43 was more highly expressed in the intact IL striatum and the peri-infarct tissue (p<0.05; Fig. 7) and the CL DG hippocampus (p=0.01; Fig. 7) of the stroke brains.
Gene_expression (expressed) of GAP 43 in brains associated with stroke and hippocampus
8) Confidence 0.69 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.24 Pain Relevance 0.22
Spinal cords were processed immunohistochemically at the injury/transplantation site for characterization of NSC survival and differentiation; and at the cervicothoracic level for calcitonin gene-related peptide (CGRP), a neuropeptide expressed in dorsal horn nocioceptive neurons, and growth-associated protein-43 (GAP43), a marker of neuronal sprouting.
Gene_expression (expressed) of GAP43 in neuronal associated with injury, dorsal horn, neuropeptide and calcitonin gene-related peptide
9) Confidence 0.66 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16839548 Disease Relevance 0.80 Pain Relevance 0.81
Spinal cords were processed immunohistochemically at the injury/transplantation site for characterization of NSC survival and differentiation; and at the cervicothoracic level for calcitonin gene-related peptide (CGRP), a neuropeptide expressed in dorsal horn nocioceptive neurons, and growth-associated protein-43 (GAP43), a marker of neuronal sprouting.
Gene_expression (expressed) of growth-associated protein-43 in neuronal associated with injury, dorsal horn, neuropeptide and calcitonin gene-related peptide
10) Confidence 0.66 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16839548 Disease Relevance 0.79 Pain Relevance 0.80
Correlation between MRI data and GAP43/rOD values was performed using the Spearman r test.
Gene_expression (values) of GAP43 associated with imagery
11) Confidence 0.60 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.31 Pain Relevance 0.29
From these results, we conclude that both GAP-43 and SCG10 mRNAs are expressed in the excitatory relay neurons of the monkey LGN in an activity-dependent manner.
Gene_expression (expressed) of GAP-43 in LGN
12) Confidence 0.59 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10934252 Disease Relevance 0 Pain Relevance 0.17
GAP-43 expression was significantly higher in the experimental group than in the control group (p<0.01).
Gene_expression (expression) of GAP-43
13) Confidence 0.55 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2263011 Disease Relevance 0.50 Pain Relevance 0
The expressed GAP-43 is located in the growth cone of the regenerating axon.
Gene_expression (expressed) of GAP-43 in growth cone
14) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.70 Pain Relevance 0.16
Positive expression of GAP-43 in our figures indicate regeneration of axon of optic neve.
Gene_expression (expression) of GAP-43 in optic
15) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.72 Pain Relevance 0.16
In contrast, cells with cytoplasmic staining for Gap43, located in the middle portions of the epithelium, were mostly immunopositive for SgIGSF.
Gene_expression (staining) of Gap43 in epithelium
16) Confidence 0.54 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0 Pain Relevance 0
In the stroke group, GAP-43 expression and FA values were significantly higher in the ipsilateral (IL) striatum and contralateral (CL) hippocampus compared to the shams.
Gene_expression (expression) of GAP-43 in hippocampus associated with stroke and hippocampus
17) Confidence 0.53 Published 2007 Journal The Open Neuroimaging Journal Section Abstract Doc Link PMC2577937 Disease Relevance 0.60 Pain Relevance 0.13
FA) and 2. the difference between IL and CL GAP 43 rOD values (?
Gene_expression (values) of GAP 43
18) Confidence 0.52 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.41 Pain Relevance 0.29
We also showed that GABA-immunoreactive neurons in the LGN did not contain GAP-43 and SCG10 mRNAs, indicating that neither GAP-43 nor SCG10 mRNAs were expressed in inhibitory interneurons in the LGN.
Neg (not) Gene_expression (contain) of GAP-43 in LGN associated with gaba
19) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10934252 Disease Relevance 0 Pain Relevance 0.15
Expression of GAP-43 and SCG10 mRNAs in lateral geniculate nucleus of normal and monocularly deprived macaque monkeys.
Gene_expression (Expression) of GAP-43 in lateral geniculate nucleus
20) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Title Doc Link 10934252 Disease Relevance 0 Pain Relevance 0.07

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