INT73359

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.18
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLB1) carbohydrate metabolic process (GLB1) cytoplasm (GLB1)
Anatomy Link Frequency
skin 2
hepatocyte 1
epithelial cells 1
PVN 1
reticulum 1
GLB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 9 99.22 Very High Very High Very High
gABA 8 94.84 High High
palliative 3 88.68 High High
opiate 3 88.64 High High
Morphine 6 86.52 High High
cINOD 3 83.84 Quite High
anesthesia 1 81.12 Quite High
Pain 2 76.76 Quite High
Opioid 3 75.00 Quite High
midbrain 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Aging 4 100.00 Very High Very High Very High
Targeted Disruption 2 99.86 Very High Very High Very High
Cold Sores 4 99.68 Very High Very High Very High
Toxicity 1 96.76 Very High Very High Very High
Stress 8 96.32 Very High Very High Very High
Emphysema 29 93.40 High High
Apoptosis 10 91.88 High High
Hepatocellular Cancer 3 90.88 High High
Renal Cancer 4 87.76 High High
Pulmonary Emphysema 15 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Gene_expression (expression) of EBP in reticulum associated with stress
1) Confidence 0.75 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
Freshly excised human skin was used to characterise microneedle penetration (microscopy and skin water loss), gel residence in microchannels, pDNA diffusion and reporter gene (beta-galactosidase) expression.
Gene_expression (expression) of beta-galactosidase in skin
2) Confidence 0.72 Published 2008 Journal Pharm. Res. Section Body Doc Link 17671832 Disease Relevance 0 Pain Relevance 0
Following optimisation of skin explant culturing techniques and confirmation of tissue viability, the ability of the micro-needles to mediate gene expression was demonstrated using the beta-galactosidase reporter gene.
Gene_expression (using) of beta-galactosidase in skin
3) Confidence 0.67 Published 2005 Journal J Drug Target Section Abstract Doc Link 16308210 Disease Relevance 0.08 Pain Relevance 0.08
In animals receiving either vector alone or vector with perflubron, in situ beta-galactosidase expression was observed in a variety of cells including large airway, bronchiolar, and alveolar epithelial cells.
Gene_expression (expression) of beta-galactosidase in epithelial cells
4) Confidence 0.65 Published 2002 Journal Mol. Ther. Section Abstract Doc Link 11786040 Disease Relevance 0 Pain Relevance 0.12
Here we use a transgenic mouse model expressing a human proenkephalin-beta-galactosidase fusion gene, in which both up-regulation and down-regulation of gene expression can be measured easily, to study the effects of GABA on basal and stress-induced gene expression within the PVN.
Gene_expression (expressing) of proenkephalin-beta-galactosidase in PVN associated with stress, targeted disruption and gaba
5) Confidence 0.10 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9453554 Disease Relevance 0.40 Pain Relevance 0.34
In one study, those cells were shown to express senescence-associated beta-galactosidase (SA-beta-Gal), a marker of cellular senescence (Muller et al 2006).
Gene_expression (express) of beta-galactosidase associated with aging
6) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699955 Disease Relevance 0.90 Pain Relevance 0
The emulsion was prepared by mixing pieces of GSP and adenoviral vectors expressing recombinant beta-galactosidase (Ad.LacZ) or human hepatocyte growth factor (Ad.hHGF).
Gene_expression (expressing) of recombinant beta-galactosidase in hepatocyte
7) Confidence 0.05 Published 2005 Journal Cancer Gene Ther. Section Abstract Doc Link 15578067 Disease Relevance 0.18 Pain Relevance 0.09
No such anatomical specificity is seen in rats given VTA microinjections of HSV-LacZ, a vector expressing a control protein (-galactosidase).
Gene_expression (expressing) of galactosidase associated with ventral tegmentum and cold sores
8) Confidence 0.00 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.46 Pain Relevance 1.08

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