INT73365

Context Info Confidence 0.67 First Reported 1998 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 10 Total Number 11 Disease Relevance 3.80 Pain Relevance 1.36

Anatomy Link Frequency plasma 2 kidney 2 nerves 1 HGF 1 Ang (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 5 99.48 anesthesia 18 99.24 Calcitonin gene-related peptide 11 98.96 Neurotransmitter 3 94.60 Spinal cord 3 75.00 guanethidine 1 68.08 Inflammation 19 67.60 antagonist 6 64.88 Central nervous system 36 51.60 Hippocampus 5 33.76

Disease Link Frequency Relevance Heat Neurodegenerative Disease 28 100.00 Hypertension 39 99.12 Hypoxia 11 99.10 Acquired Immune Deficiency Syndrome Or Hiv Infection 83 80.80 Diabetes Mellitus 3 78.80 Toxicity 4 73.72 Infection 34 68.80 INFLAMMATION 26 67.60 Increased Venous Pressure Under Development 3 60.56 Apoptosis 5 56.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Salt depletion caused marked increases in ANG II levels in HanSD but did not alter them in TGR.

Positive_regulation (increases) of ANG

1) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.08 Pain Relevance 0

BACKGROUND: Previous studies have implicated that normotensive rats with normal renal renin activity respond to anesthesia and surgery with greater increases in plasma and kidney angiotensin II (ANG II) concentrations than ANG II-dependent hypertensive rats with intrarenal renin depletion.

Positive_regulation (increases) of ANG in kidney associated with anesthesia and hypertension

2) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16651849 Disease Relevance 0.17 Pain Relevance 0.17

CONCLUSIONS: These findings indicate that anesthesia increases plasma and kidney ANG II levels in HanSD to a greater degree than in ANG II-dependent models of hypertension.

Positive_regulation (increases) of ANG in kidney

3) Confidence 0.59 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.06 Pain Relevance 0

This study tested the hypothesis that androgens enhance responsiveness to ANG II during the development of hypertension in New Zealand genetically hypertensive (NZGH) rats.

Positive_regulation (enhance) of ANG associated with hypertension

4) Confidence 0.38 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.46 Pain Relevance 0.07

While most ANG induced events were tetrodotoxin-sensitive, ANG induced a significant tetrodotoxin-resistant increase in frequency but not amplitude of miniature IPSCs (n = 7/13 cells) and EPSCs (n = 2/7 cells).

Positive_regulation (induced) of ANG associated with tetrodotoxin

5) Confidence 0.37 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16061493 Disease Relevance 0 Pain Relevance 0.45

The role of angiotensin (Ang) in neurotransmission of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves in perfused mesenteric vascular beds isolated from spontaneously hypertensive rats (SHR) (8- and 15-week-old) and age-matched Wistar Kyoto rats (WKY) was investigated.

Spec (investigated) Positive_regulation (role) of Ang in nerves associated with hypertension and calcitonin gene-related peptide

6) Confidence 0.35 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454791 Disease Relevance 0.28 Pain Relevance 0.31

At the highest ANG II dose, MAP increased by 40+/-4% in Sham vs. 22+/-1% in Cas NZGH rats of 16-17 wk of age.

Positive_regulation (increased) of ANG associated with hypertension

7) Confidence 0.31 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.73 Pain Relevance 0.09

BACKGROUND: Previous studies have implicated that normotensive rats with normal renal renin activity respond to anesthesia and surgery with greater increases in plasma and kidney angiotensin II (ANG II) concentrations than ANG II-dependent hypertensive rats with intrarenal renin depletion.

Positive_regulation (increases) of ANG in plasma associated with anesthesia and hypertension

8) Confidence 0.23 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16651849 Disease Relevance 0.17 Pain Relevance 0.17

CONCLUSIONS: These findings indicate that anesthesia increases plasma and kidney ANG II levels in HanSD to a greater degree than in ANG II-dependent models of hypertension.

Positive_regulation (increases) of ANG in plasma

9) Confidence 0.20 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.06 Pain Relevance 0

Importantly, several lines of evidence suggest that insulin and insulin-like growth factor (IGF) are very important in ANG.

Positive_regulation (important) of ANG associated with neurodegenerative disease

10) Confidence 0.15 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.38 Pain Relevance 0.11

Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).

Positive_regulation (accumulation) of Angiogenin in HGF associated with hypoxia

11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0

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