INT73365

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.80
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
kidney 2
nerves 1
HGF 1
Ang (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 5 99.48 Very High Very High Very High
anesthesia 18 99.24 Very High Very High Very High
Calcitonin gene-related peptide 11 98.96 Very High Very High Very High
Neurotransmitter 3 94.60 High High
Spinal cord 3 75.00 Quite High
guanethidine 1 68.08 Quite High
Inflammation 19 67.60 Quite High
antagonist 6 64.88 Quite High
Central nervous system 36 51.60 Quite High
Hippocampus 5 33.76 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 28 100.00 Very High Very High Very High
Hypertension 39 99.12 Very High Very High Very High
Hypoxia 11 99.10 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 80.80 Quite High
Diabetes Mellitus 3 78.80 Quite High
Toxicity 4 73.72 Quite High
Infection 34 68.80 Quite High
INFLAMMATION 26 67.60 Quite High
Increased Venous Pressure Under Development 3 60.56 Quite High
Apoptosis 5 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Salt depletion caused marked increases in ANG II levels in HanSD but did not alter them in TGR.
Positive_regulation (increases) of ANG
1) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.08 Pain Relevance 0
BACKGROUND: Previous studies have implicated that normotensive rats with normal renal renin activity respond to anesthesia and surgery with greater increases in plasma and kidney angiotensin II (ANG II) concentrations than ANG II-dependent hypertensive rats with intrarenal renin depletion.
Positive_regulation (increases) of ANG in kidney associated with anesthesia and hypertension
2) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16651849 Disease Relevance 0.17 Pain Relevance 0.17
CONCLUSIONS: These findings indicate that anesthesia increases plasma and kidney ANG II levels in HanSD to a greater degree than in ANG II-dependent models of hypertension.
Positive_regulation (increases) of ANG in kidney
3) Confidence 0.59 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.06 Pain Relevance 0
This study tested the hypothesis that androgens enhance responsiveness to ANG II during the development of hypertension in New Zealand genetically hypertensive (NZGH) rats.
Positive_regulation (enhance) of ANG associated with hypertension
4) Confidence 0.38 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.46 Pain Relevance 0.07
While most ANG induced events were tetrodotoxin-sensitive, ANG induced a significant tetrodotoxin-resistant increase in frequency but not amplitude of miniature IPSCs (n = 7/13 cells) and EPSCs (n = 2/7 cells).
Positive_regulation (induced) of ANG associated with tetrodotoxin
5) Confidence 0.37 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16061493 Disease Relevance 0 Pain Relevance 0.45
The role of angiotensin (Ang) in neurotransmission of calcitonin gene-related peptide (CGRP)-containing vasodilator nerves in perfused mesenteric vascular beds isolated from spontaneously hypertensive rats (SHR) (8- and 15-week-old) and age-matched Wistar Kyoto rats (WKY) was investigated.
Spec (investigated) Positive_regulation (role) of Ang in nerves associated with hypertension and calcitonin gene-related peptide
6) Confidence 0.35 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454791 Disease Relevance 0.28 Pain Relevance 0.31
At the highest ANG II dose, MAP increased by 40+/-4% in Sham vs. 22+/-1% in Cas NZGH rats of 16-17 wk of age.
Positive_regulation (increased) of ANG associated with hypertension
7) Confidence 0.31 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.73 Pain Relevance 0.09
BACKGROUND: Previous studies have implicated that normotensive rats with normal renal renin activity respond to anesthesia and surgery with greater increases in plasma and kidney angiotensin II (ANG II) concentrations than ANG II-dependent hypertensive rats with intrarenal renin depletion.
Positive_regulation (increases) of ANG in plasma associated with anesthesia and hypertension
8) Confidence 0.23 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16651849 Disease Relevance 0.17 Pain Relevance 0.17
CONCLUSIONS: These findings indicate that anesthesia increases plasma and kidney ANG II levels in HanSD to a greater degree than in ANG II-dependent models of hypertension.
Positive_regulation (increases) of ANG in plasma
9) Confidence 0.20 Published 2006 Journal Kidney Blood Press. Res. Section Body Doc Link 16651849 Disease Relevance 0.06 Pain Relevance 0
Importantly, several lines of evidence suggest that insulin and insulin-like growth factor (IGF) are very important in ANG.
Positive_regulation (important) of ANG associated with neurodegenerative disease
10) Confidence 0.15 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.38 Pain Relevance 0.11
Indeed, hypoxia (1.5% O2) induced a significant increase in accumulation of selected factors like Angiogenin, HGF, IL-8, PDGF-BB, SDF-1 and VEGF-A in the EPC conditioned media compared to normoxia (P<0.05; Table 1).
Positive_regulation (accumulation) of Angiogenin in HGF associated with hypoxia
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0

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