INT73382

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 1.58
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
spinal cord 3
brainstem 2
liver 1
spinal cord ventral horn 1
motoneurons 1
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 20 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
guanethidine 6 99.84 Very High Very High Very High
electroacupuncture 10 99.82 Very High Very High Very High
Neuronal nitric oxide synthase 4 99.80 Very High Very High Very High
Catecholamine 4 99.64 Very High Very High Very High
Spinal cord 19 99.48 Very High Very High Very High
medulla 8 98.28 Very High Very High Very High
local anesthetic 2 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myalgia 1 100.00 Very High Very High Very High
Frailty 8 98.64 Very High Very High Very High
Hypertension 4 97.20 Very High Very High Very High
Injury 3 93.12 High High
Prostate Cancer 28 83.20 Quite High
Toxicity 4 78.24 Quite High
Cancer 5 71.88 Quite High
INFLAMMATION 4 71.60 Quite High
Increased Venous Pressure Under Development 2 65.04 Quite High
Stress 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dimethyl fumarate, on the other hand, induces NQO1 enzymatic activity in the forestomach, small intestine, kidneys and lungs, but produces little change in NQO1 activity in the liver [11].
Neg (little) Regulation (change) of NQO1 in liver
1) Confidence 0.58 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0.22 Pain Relevance 0
Electroacupuncture-related changes of NADPH-diaphorase and neuronal nitric oxide synthase in the brainstem of spontaneously hypertensive rats.
Regulation (changes) of NADPH-diaphorase in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
2) Confidence 0.37 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11595335 Disease Relevance 0.18 Pain Relevance 0.63
The aim of this study was to investigate the electroacupuncture-related changes of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) in the brainstem of spontaneously hypertensive rats (SHR).
Regulation (changes) of phosphate-diaphorase in brainstem associated with medulla, hypertension, electroacupuncture and neuronal nitric oxide synthase
3) Confidence 0.32 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11595335 Disease Relevance 0.17 Pain Relevance 0.29
Age-related changes in NADPH-diaphorase activity were studied using a histochemical method in spinal cord ventral horn motoneurons at different segmental levels in rats aged 3-90 days from birth in normal conditions and after modeling of chemical deafferentation by i.p. administration of capsaicin.
Regulation (changes) of NADPH-diaphorase in spinal cord ventral horn associated with qutenza, deafferentation and spinal cord
4) Confidence 0.27 Published 2010 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 20339934 Disease Relevance 0 Pain Relevance 0.32
Age-related changes in NADPH-diaphorase activity in spinal cord motoneurons in intact rats characterize constructive processes in neurons, while changes seen after deafferentation provide evidence of motoneuron damage resulting in sharp increases in enzyme activity by age 90 days.
Regulation (changes) of NADPH-diaphorase in motoneurons associated with deafferentation and spinal cord
5) Confidence 0.27 Published 2010 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 20339934 Disease Relevance 0 Pain Relevance 0.40
Both indomethacin and its congener at 2 x 10(-5)mol/kg produced microscopic signs of thinning only, not visible irritation or alteration of diaphorase staining.
Regulation (alteration) of diaphorase
6) Confidence 0.24 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16018970 Disease Relevance 0.16 Pain Relevance 0.26
In this study, we examined the effect of acute capsaicin injection on nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d, a histochemical index of nitric oxide, NO, synthase) and Fos expression in the rat pituitary gland.
Spec (examined) Regulation (effect) of diaphorase in pituitary gland associated with qutenza
7) Confidence 0.20 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11090977 Disease Relevance 0 Pain Relevance 0.41
Modulation of quinolinic acid-induced depletion of striatal NADPH diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase.
Regulation (Modulation) of NADPH diaphorase in neurons associated with enkephalin
8) Confidence 0.19 Published 1999 Journal Brain Res. Section Title Doc Link 9889356 Disease Relevance 0.08 Pain Relevance 0.18
Capsaicin-induced effects on c-fos expression and NADPH-diaphorase activity in the feline spinal cord.
Regulation (effects) of NADPH-diaphorase in spinal cord associated with qutenza and spinal cord
9) Confidence 0.18 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16168409 Disease Relevance 0 Pain Relevance 0.60
Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury.
Regulation (effects) of NADPH-diaphorase in spinal cord associated with pain and spinal cord
10) Confidence 0.12 Published 2001 Journal Brain Res. Section Title Doc Link 11532430 Disease Relevance 0.54 Pain Relevance 0.60
Following incubation with 6-hydroxydopamine for 1 hr, the catecholamine fluorescence fibers in the basilar arteries completely disappeared, although the NADPH-diaphorase fibers were not affected.
Neg (not) Regulation (affected) of NADPH-diaphorase associated with catecholamine
11) Confidence 0.04 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454828 Disease Relevance 0.06 Pain Relevance 0.81
Results from histochemical studies indicated that catecholamine fluorescence and NADPH-diaphorase fibers were not appreciably affected by guanethidine.
Neg (not) Regulation (affected) of NADPH-diaphorase associated with guanethidine and catecholamine
12) Confidence 0.03 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454828 Disease Relevance 0.07 Pain Relevance 0.83
The activities of the NADH:ubiquinone-1 and NADH:menadione oxidoreductase were very resistant to such respiratory chain inhibitors as rotenone, capsaicin, and AgNO(3), whereas these activities were sensitive to 2-heptyl-4-hydroxyquinoline-N-oxide (HQNO).
Regulation (resistant) of menadione oxidoreductase in respiratory associated with qutenza
13) Confidence 0.01 Published 2007 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17244482 Disease Relevance 0 Pain Relevance 0.10
We analyzed the effects of restraint stress on neuronal NOS (nNOS) expression and nicotinamide adenine dinucleotide phosphate-diaphorase histochemical activity (NADPH-d) in the HF and related brain regions.
Spec (analyzed) Regulation (effects) of phosphate-diaphorase in neuronal
14) Confidence 0.01 Published 2004 Journal Neuroscience Section Body Doc Link 15120858 Disease Relevance 0 Pain Relevance 0
[Effect of muscle pain on c-fos expression and NADPH-diaphorase activity in the spinal cord].
Regulation (Effect) of NADPH-diaphorase in spinal cord associated with pain, qutenza, myalgia and spinal cord
15) Confidence 0.01 Published 2004 Journal Fiziol Zh Section Title Doc Link 15732761 Disease Relevance 0.10 Pain Relevance 0.74

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox