INT7340

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Context Info
Confidence 0.62
First Reported 1987
Last Reported 2010
Negated 20
Speculated 17
Reported most in Abstract
Documents 87
Total Number 104
Disease Relevance 30.37
Pain Relevance 57.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
neurons 6
spinal cord 5
spinal cord dorsal horn 4
brain 3
CPN 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 832 100.00 Very High Very High Very High
Spinal cord 336 100.00 Very High Very High Very High
antagonist 193 100.00 Very High Very High Very High
Glutamate 164 100.00 Very High Very High Very High
Glutamate receptor 149 100.00 Very High Very High Very High
Pain 140 100.00 Very High Very High Very High
agonist 140 100.00 Very High Very High Very High
Neurotransmitter 37 100.00 Very High Very High Very High
narcan 20 100.00 Very High Very High Very High
nociceptor 20 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 185 100.00 Very High Very High Very High
Spinal Cord Injury 5 100.00 Very High Very High Very High
Hypersensitivity 70 99.92 Very High Very High Very High
Urological Neuroanatomy 19 99.84 Very High Very High Very High
Diabetes Mellitus 265 99.82 Very High Very High Very High
Nociception 260 99.82 Very High Very High Very High
Li-fraumeni Syndrome 55 99.82 Very High Very High Very High
Depression 232 99.74 Very High Very High Very High
Neuropathic Pain 147 99.56 Very High Very High Very High
Hyperalgesia 195 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that Group I mGluRs can modulate NMDAR functions in the central nervous system.
Regulation (modulate) of NMDAR in central nervous system associated with central nervous system
1) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.06
In this study, the authors examined the effect of subcutaneous injection of siRNA targeting the NR1 subunit of the N-methyl-D-aspartate receptor on silencing NR1 gene expression and subsequently abolishing inflammatory nociception in rats.
Regulation (targeting) of NR1 associated with nociception, inflammation and nmda receptor
2) Confidence 0.62 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20463582 Disease Relevance 0.43 Pain Relevance 0.39
In this study, the authors examined the effect of subcutaneous injection of siRNA targeting the NR1 subunit of the N-methyl-D-aspartate receptor on silencing NR1 gene expression and subsequently abolishing inflammatory nociception in rats.
Regulation (targeting) of N-methyl-D-aspartate receptor associated with nociception, inflammation and nmda receptor
3) Confidence 0.62 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20463582 Disease Relevance 0.43 Pain Relevance 0.39
We examined the effects of chronic ethanol exposure on the levels of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) protein, an essential component of N-methyl-D-aspartate glutamate receptors, in rat brain.
Spec (examined) Regulation (effects) of N-methyl-D-aspartate receptor subunit 1 in brain associated with glutamate receptor and nmda receptor
4) Confidence 0.62 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133290 Disease Relevance 0 Pain Relevance 0.34
Thus, it may take up to 14 days before more chronic changes occur, such as NMDA NR1 receptor up-regulation.
Regulation (regulation) of NR1 receptor
5) Confidence 0.60 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.94 Pain Relevance 0.30
Unlike cocaine, morphine, and stress, repeated treatment with other psychotropic drugs (haloperidol, raclopride, sertraline, and desipramine) that lack reinforcing or sensitizing properties did not regulate GluR1 or NMDAR1 subunit levels in the VTA.
Neg (not) Regulation (regulate) of NMDAR1 subunit associated with stress, ventral tegmentum, desipramine, morphine and cocaine
6) Confidence 0.58 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.40 Pain Relevance 1.04
Moreover, GluR1 and NMDAR1 levels were not regulated in other regions of the mesolimbic or nigrostriatal DA pathways, including the substantia nigra.
Neg (not) Regulation (regulated) of NMDAR1 in substantia nigra associated with dopamine and substantia nigra
7) Confidence 0.58 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.30 Pain Relevance 1.04
NMDAR function is modulated by post-translational modifications including phosphorylation, and this is proposed to underlie its involvement in the production of pain hypersensitivity in the spinal cord.
Regulation (modulated) of NMDAR in spinal cord associated with hypersensitivity, stimulus evoked pain and spinal cord
8) Confidence 0.57 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15233747 Disease Relevance 0.39 Pain Relevance 0.64
The NR1 mRNA levels were unchanged in the lateral paragigantocellular nucleus, locus coeruleus, periaqueductal grey, and sensorimotor cortex.
Neg (unchanged) Regulation (unchanged) of NR1 mRNA in cortex associated with periaqueductal grey and locus ceruleus
9) Confidence 0.56 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.10 Pain Relevance 1.41
Co-administration of LY274614 (s.c. at 24 mg/kg/24 h via an osmotic pump) not only attenuated the development of morphine tolerance but also prevented the changes in the NR1 mRNA levels induced by chronic morphine administration.
Regulation (changes) of NR1 mRNA associated with tolerance and morphine
10) Confidence 0.56 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.09 Pain Relevance 1.80
We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.
Neg (without) Regulation (affecting) of NR1 in PP2A associated with qutenza
11) Confidence 0.52 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15919130 Disease Relevance 0 Pain Relevance 0.83
No changes of NR1, NR2A, NR2C subunit mRNA in the cerebellar granule cell layer were observed in either butorphanol tolerant or withdrawal rats.
Neg (No) Regulation (changes) of NR1 in cerebellar granule cell associated with butorphanol and withdrawal
12) Confidence 0.52 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11152389 Disease Relevance 0 Pain Relevance 1.78
Diabetes induced changes in the NR1 subunit protein levels in the retina (Figure 4A).
Regulation (changes) of NR1 subunit in retina associated with diabetes mellitus
13) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.01 Pain Relevance 0.08
Also, in diabetic human postmortem retinas we have found that GluR2 and NR1 subunits are altered, mainly at the plexiform layers and ganglion cell layer [30].
Regulation (altered) of NR1 in ganglion cell layer associated with ganglion cysts and diabetes mellitus
14) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.57 Pain Relevance 0.24
In the present experiments, we examined (1) the cellular distribution of a PKC isoform (PKC gamma) in the spinal cord dorsal horn of rats associated with morphine tolerance by utilizing an immunocytochemical method and (2) the effects of the N-methyl-D-aspartate receptor antagonist MK-801 on tolerance-associated PKC gamma changes.
Regulation (effects) of N-methyl-D-aspartate receptor in spinal cord dorsal horn associated with kinase c, antagonist, nmda receptor, tolerance, dorsal horn, morphine and spinal cord
15) Confidence 0.47 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552251 Disease Relevance 0 Pain Relevance 1.82
Morphine did not change the NMDAR1 mRNA level in the hippocampal formation, but chronic cocaine did decrease it in the dentate gyrus only.
Neg (not) Regulation (change) of NMDAR1 mRNA in dentate gyrus associated with cocaine and morphine
16) Confidence 0.45 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.08 Pain Relevance 1.22
We studied the in vivo effect of two selective N-methyl-D-aspartate receptor antagonists on the compressed spinal cord segments of rats harboring a thoracolumbar epidural tumor.
Regulation (effect) of N-methyl-D-aspartate receptor in spinal cord segments associated with antagonist, nmda receptor, epidural and spinal cord
17) Confidence 0.45 Published 1990 Journal Neurosurgery Section Abstract Doc Link 2163498 Disease Relevance 0.38 Pain Relevance 0.32
The effect of other clinically available N-methyl-D-aspartate receptor antagonists on these responses was also studied.
Regulation (effect) of N-methyl-D-aspartate receptor associated with antagonist and nmda receptor
18) Confidence 0.45 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12170054 Disease Relevance 0 Pain Relevance 0.45
Because of the importance of NR1 in central sensitization, the first goal of this study was to examine both time- and lamina-dependent changes in spinal NR1 and pNR1 expression in a chronic constriction injury (CCI) model of neuropathic pain.
Spec (examine) Regulation (changes) of NR1 in spinal associated with central sensitization, eae, injury and neuropathic pain
19) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.58 Pain Relevance 0.72
Thus, we next examined whether the depletion of CSPAs with resiniferatoxin (RTX) modified the change of spinal NR1 and pNR1 expression induced by CCI.
Spec (whether) Regulation (change) of NR1 in spinal associated with eae
20) Confidence 0.45 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 0.97 Pain Relevance 0.97

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