INT7341

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 7
Speculated 6
Reported most in Abstract
Documents 169
Total Number 178
Disease Relevance 65.86
Pain Relevance 118.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
spinal 13
neurons 11
hippocampus 7
spinal cord 6
dorsal horn 6
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 1171 100.00 Very High Very High Very High
Inflammation 545 100.00 Very High Very High Very High
Morphine 497 100.00 Very High Very High Very High
antagonist 411 100.00 Very High Very High Very High
Glutamate receptor 330 100.00 Very High Very High Very High
amygdala 251 100.00 Very High Very High Very High
Spinal cord 249 100.00 Very High Very High Very High
Neurotransmitter 97 100.00 Very High Very High Very High
electroacupuncture 55 100.00 Very High Very High Very High
narcan 25 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 661 100.00 Very High Very High Very High
Stress 486 99.98 Very High Very High Very High
Depression 747 99.90 Very High Very High Very High
Hypoxia 468 99.84 Very High Very High Very High
Injury 338 99.84 Very High Very High Very High
INFLAMMATION 602 99.82 Very High Very High Very High
Nervous System Injury 82 99.80 Very High Very High Very High
Nociception 167 99.56 Very High Very High Very High
Hyperalgesia 485 99.44 Very High Very High Very High
Toxicity 85 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIDA or MPEP co-administered with morphine attenuated morphine induced upregulation of NR1.
Positive_regulation (upregulation) of NR1 associated with morphine
1) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19348736 Disease Relevance 0 Pain Relevance 1.70
Acute or chronic morphine and cocaine administration increased NMDAR1 mRNA level in the central and basolateral nuclei of the amygdala; morphine did so 3 h after the last dose and 48 h after withdrawal, cocaine 3 h after acute and last chronic dose.
Positive_regulation (increased) of NMDAR1 mRNA in amygdala associated with withdrawal, amygdala, cocaine and morphine
2) Confidence 0.70 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 14636974 Disease Relevance 0.08 Pain Relevance 1.15
Increased NMDAR1 subunit levels in the hippocampus after chronic ethanol exposure may represent an important neurochemical substrate for some of the features associated with ethanol dependence and withdrawal.
Positive_regulation (Increased) of NMDAR1 subunit in hippocampus associated with addiction, hippocampus and withdrawal
3) Confidence 0.70 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133290 Disease Relevance 0 Pain Relevance 0.66
The immunoreactive labeling of the NMDAR1 was increased in the cervical spinal cord ipsilateral to the DRGn from day 5 to 14 after DRGn.
Positive_regulation (increased) of NMDAR1 in spinal cord associated with ganglionectomy and spinal cord
4) Confidence 0.69 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10822148 Disease Relevance 0 Pain Relevance 0.60
Interestingly, RTX treatment significantly attenuated the CCI-induced upregulation of NR1 and pNR1 in spinal laminae I-II and V-VI, but not laminae III-IV as compared with that of vehicle-treated CCI rats.
Positive_regulation (upregulation) of NR1 in spinal associated with eae
5) Confidence 0.69 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17933570 Disease Relevance 1.16 Pain Relevance 1.07
Western blots showed that phosphorylated NR1 protein in spinal cord tissue was increased 30 min after CAP injection.
Positive_regulation (increased) of NR1 in spinal cord associated with qutenza and spinal cord
6) Confidence 0.69 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10995844 Disease Relevance 0.16 Pain Relevance 1.13
Furthermore, activation of the N-methyl-D-aspartate receptor is also necessary to elicit the immediate-onset motor effects and inhibition of the tail-flick reflex produced by greater doses of spermine.
Positive_regulation (activation) of N-methyl-D-aspartate receptor in tail associated with nmda receptor and tail-flick
7) Confidence 0.68 Published 1994 Journal Neuroscience Section Abstract Doc Link 7535397 Disease Relevance 0.23 Pain Relevance 0.69
Figure 2A demonstrates an increase in NR1 mRNA at 14 (p < 0.05), 21 (p < 0.05) and 28 days (p < 0.05).
Positive_regulation (increase) of NR1
8) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.41 Pain Relevance 0.08
Therefore, inhibiting astrocytic activation (e.g. with LAA in our study) could down-regulate activation of NMDAR via preventing glutamate release from astrocytes.
Positive_regulation (activation) of NMDAR in astrocytes associated with glutamate
9) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.41 Pain Relevance 0.80
Repeated restraint stress also paradigm (2 stressors/d under variable conditions) increased both GluR1 and NMDAR1 levels in this brain region.
Positive_regulation (increased) of NMDAR1 in brain associated with stress
10) Confidence 0.66 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.43 Pain Relevance 1.13
Chronic treatment with dizocilpine maleate induced a moderate but significant increase in messenger RNA of the N-methyl-D-aspartate receptor 1 subunit in the striatum and the adjacent cortex, suggesting an action of dizocilpine maleate in these two regions.
Positive_regulation (increase) of N-methyl-D-aspartate receptor in cortex associated with nmda receptor
11) Confidence 0.64 Published 1995 Journal Neuroscience Section Abstract Doc Link 7539897 Disease Relevance 0.16 Pain Relevance 0.41
Co-administration of LY274614 (s.c. at 24 mg/kg/24 h via an osmotic pump) not only attenuated the development of morphine tolerance but also prevented the changes in the NR1 mRNA levels induced by chronic morphine administration.
Positive_regulation (induced) of NR1 mRNA associated with tolerance and morphine
12) Confidence 0.64 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12829326 Disease Relevance 0.09 Pain Relevance 1.80
The results suggested that activation of N-methyl-D-aspartate receptor 1 and glutamate receptor 2/3 upon glutamate release in response to noxious stimulation to the orofacial region might mediate c-fos expression in neurons involved in nociception.
Spec (might) Positive_regulation (activation) of N-methyl-D-aspartate receptor 1 in neurons associated with nociception, glutamate, glutamate receptor and nmda receptor
13) Confidence 0.61 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650136 Disease Relevance 0.29 Pain Relevance 0.41
Chronic morphine (10 microg, i.t.; twice daily for 6 d) induced a time-dependent upregulation of GR, the NR1 subunit of NMDAR, and PKCgamma within the rat's spinal cord dorsal horn.
Positive_regulation (upregulation) of NMDAR in spinal cord dorsal horn associated with dorsal horn, spinal cord and morphine
14) Confidence 0.61 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.15
Moreover, the expression of phosphorylated CREB was upregulated within the spinal cord dorsal horn after chronic morphine, and a CREB antisense oligodeoxynucleotide coadministered intrathecally with morphine prevented the upregulation of GR, NR1, and PKCgamma.
Positive_regulation (upregulation) of NR1 in spinal cord dorsal horn associated with dorsal horn, morphine and spinal cord
15) Confidence 0.61 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.41
This NR1 and PKCgamma upregulation was significantly diminished by intrathecal coadministration of morphine with the GR antagonist RU38486 or a GR antisense oligodeoxynucleotide.
Positive_regulation (upregulation) of NR1 associated with antagonist, morphine and intrathecal
16) Confidence 0.61 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319314 Disease Relevance 0 Pain Relevance 1.28
Besides, nitric oxide (NO) released following NMDAR activation could induce astrocytic activation [43].
Positive_regulation (activation) of NMDAR
17) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.36 Pain Relevance 1.28
These investigators found that capsaicin injection into the hind paw of rats resulted in an ipsilateral accumulation of phosphorylated NR1 subunits in spinothalamic tract neurons.
Positive_regulation (accumulation) of NR1 in neurons associated with qutenza and spinothalamic tract neurons
18) Confidence 0.56 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.07 Pain Relevance 0.82
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Positive_regulation (increase) of NR1 in hippocampus associated with nucleus accumbens, hippocampus and cocaine
19) Confidence 0.56 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.34
In our case, we found that NR1 subunit protein levels were not elevated throughout the complete course of diabetes; NR1 subunit protein levels were downregulated at one week, upregulated at four weeks, and downregulated at 12 weeks.
Neg (not) Positive_regulation (elevated) of NR1 subunit associated with diabetes mellitus
20) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.80 Pain Relevance 0.10

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