INT7342

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Context Info
Confidence 0.50
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 9.22
Pain Relevance 13.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
cortex 5
neurons 4
spinal cord dorsal horn 4
hippocampus 3
spike 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 211 100.00 Very High Very High Very High
Glutamate 75 100.00 Very High Very High Very High
Glutamate receptor 38 100.00 Very High Very High Very High
long-term potentiation 178 99.98 Very High Very High Very High
Inflammation 141 99.98 Very High Very High Very High
Morphine 74 99.98 Very High Very High Very High
Ventral tegmentum 18 99.64 Very High Very High Very High
Spinal cord 65 99.52 Very High Very High Very High
Spinothalamic tract neurons 2 99.48 Very High Very High Very High
qutenza 1 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 97 100.00 Very High Very High Very High
INFLAMMATION 145 99.98 Very High Very High Very High
Nervous System Injury 51 99.80 Very High Very High Very High
Nociception 54 99.78 Very High Very High Very High
Toxicity 17 99.72 Very High Very High Very High
Drug Induced Neurotoxicity 6 98.72 Very High Very High Very High
Depression 65 98.32 Very High Very High Very High
Li-fraumeni Syndrome 3 98.32 Very High Very High Very High
Injury 53 97.96 Very High Very High Very High
Neuropathic Pain 209 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MK-801 also partially antagonized quisqualic acid-mediated neurotoxicity, suggesting that quisqualic acid-induced toxicity is, in part, mediated through N-methyl-D-aspartate receptor activation.
Positive_regulation (mediated) of Positive_regulation (activation) of N-methyl-D-aspartate receptor associated with toxicity, drug induced neurotoxicity and nmda receptor
1) Confidence 0.50 Published 1990 Journal Neuroscience Section Abstract Doc Link 2234402 Disease Relevance 0.68 Pain Relevance 0.09
Collectively, these findings establish that in intact hippocampus, activity at the glycine modulatory site is necessary for activation of the N-methyl-D-aspartate receptor complex.
Positive_regulation (necessary) of Positive_regulation (activation) of N-methyl-D-aspartate receptor in hippocampus associated with nmda receptor and hippocampus
2) Confidence 0.47 Published 1992 Journal Neuroscience Section Abstract Doc Link 1347648 Disease Relevance 0 Pain Relevance 0.51
Chronic treatment with dizocilpine maleate induced a moderate but significant increase in messenger RNA of the N-methyl-D-aspartate receptor 1 subunit in the striatum and the adjacent cortex, suggesting an action of dizocilpine maleate in these two regions.
Positive_regulation (induced) of Positive_regulation (increase) of N-methyl-D-aspartate receptor in cortex associated with nmda receptor
3) Confidence 0.46 Published 1995 Journal Neuroscience Section Abstract Doc Link 7539897 Disease Relevance 0.16 Pain Relevance 0.42
Chronic constriction nerve injury (CCI) in rats induced a time-dependent upregulation of NR1 and NR2 subunits of the NMDAR within the spinal cord dorsal horn ipsilateral to CCI.
Positive_regulation (induced) of Positive_regulation (upregulation) of NR1 in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
4) Confidence 0.44 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 0.84 Pain Relevance 0.52
The results suggested that activation of N-methyl-D-aspartate receptor 1 and glutamate receptor 2/3 upon glutamate release in response to noxious stimulation to the orofacial region might mediate c-fos expression in neurons involved in nociception.
Spec (might) Positive_regulation (mediate) of Spec (might) Positive_regulation (activation) of N-methyl-D-aspartate receptor 1 in neurons associated with nociception, glutamate, glutamate receptor and nmda receptor
5) Confidence 0.44 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650136 Disease Relevance 0.30 Pain Relevance 0.42
Besides, nitric oxide (NO) released following NMDAR activation could induce astrocytic activation [43].
Positive_regulation (induce) of Positive_regulation (activation) of NMDAR
6) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.36 Pain Relevance 1.29
Besides, nitric oxide (NO) released following NMDAR activation could induce astrocytic activation [43].
Positive_regulation (following) of Positive_regulation (activation) of NMDAR
7) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.36 Pain Relevance 1.29
These investigators found that capsaicin injection into the hind paw of rats resulted in an ipsilateral accumulation of phosphorylated NR1 subunits in spinothalamic tract neurons.
Positive_regulation (resulted) of Positive_regulation (accumulation) of NR1 in neurons associated with qutenza and spinothalamic tract neurons
8) Confidence 0.38 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.07 Pain Relevance 0.83
In our case, we found that NR1 subunit protein levels were not elevated throughout the complete course of diabetes; NR1 subunit protein levels were downregulated at one week, upregulated at four weeks, and downregulated at 12 weeks.
Neg (not) Positive_regulation (elevated) of Positive_regulation (upregulated) of NR1 subunit associated with diabetes mellitus
9) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.82 Pain Relevance 0.15
Chronic constriction nerve injury (CCI) in rats induced a time-dependent upregulation of NR1 and NR2 subunits of the NMDAR within the spinal cord dorsal horn ipsilateral to CCI.
Positive_regulation (induced) of Positive_regulation (upregulation) of NMDAR in spinal cord dorsal horn associated with nervous system injury, dorsal horn and spinal cord
10) Confidence 0.32 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 0.84 Pain Relevance 0.52
Chronic compression of the dorsal root ganglia induced time-dependent upregulation of nNOS and NR2B subunits of N-methyl-D-aspartate receptor within the spinal cord dorsal horn ipsilateral to CCD.
Positive_regulation (induced) of Positive_regulation (upregulation) of N-methyl-D-aspartate receptor in dorsal root ganglia associated with nmda receptor, dorsal horn and spinal cord
11) Confidence 0.31 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.35 Pain Relevance 0.88
Functionally, nociceptive behaviors induced by NMDAR activation and CCI were reversed by a single intrathecal administration of the GR antagonist RU38486.
Positive_regulation (induced) of Positive_regulation (activation) of NMDAR associated with nociception, nervous system injury, antagonist and intrathecal
12) Confidence 0.30 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647493 Disease Relevance 1.18 Pain Relevance 0.82
Inflammation-induced NMDAR activation involves phosphorylation of the NR1 and NR2B subunits in the spinal dorsal horn by fyn proto-oncogene [28].
Positive_regulation (induced) of Positive_regulation (activation) of NMDAR in dorsal horn associated with inflammation and spinal dorsal horn
13) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2315656 Disease Relevance 1.36 Pain Relevance 1.07
Acute administration of memantine (10 mg/kg i.p.) induced an upregulation of NR1-1/NR1-2 and NR2B protein levels in the hippocampus and cortex, respectively [219].
Positive_regulation (induced) of Positive_regulation (upregulation) of NR1-1 in cortex associated with hippocampus
14) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.15 Pain Relevance 0.58
Furthermore, since TADP was also dependent on the activation of NMDAR, similar to the mechanism for the HFS or LFS induction of LTP or LTD[3]–[5], a stability hypothesis could be that forms of activity-dependent synaptic plasticity such as those with the properties of frequency, timing and sequence may work in a concert to endow stability to the hippocampal network for retaining acquired information while flexibility for learning new information, in which the system could be rapidly switched to each other.


Positive_regulation (dependent) of Positive_regulation (activation) of NMDAR associated with li-fraumeni syndrome, depression and long-term potentiation
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2475662 Disease Relevance 0.45 Pain Relevance 0.20
We have shown that masseter inflammation induced a significant increase in NMDA receptor NR1 subunit phosphorylation and GFAP levels in the Vi/Vc transition zone [17].
Positive_regulation (induced) of Positive_regulation (increase) of NMDA receptor NR1 subunit in masseter associated with inflammation and nmda receptor
16) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.95 Pain Relevance 0.73
Biochemical traits related to morphine's sensitizing effects were altered by intra-VTA anti-FGF-1 because morphine-induced upregulation of both tyrosine hydroxylase (TH) and N-methyl d-aspartate glutamate receptor 1 (NMDAR1) in the VTA was blocked after anti-FGF-1.
Positive_regulation (induced) of Positive_regulation (upregulation) of NMDAR1 associated with ventral tegmentum, glutamate receptor and morphine
17) Confidence 0.07 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.06 Pain Relevance 1.20
Biochemical traits related to morphine's sensitizing effects were altered by intra-VTA anti-FGF-1 because morphine-induced upregulation of both tyrosine hydroxylase (TH) and N-methyl d-aspartate glutamate receptor 1 (NMDAR1) in the VTA was blocked after anti-FGF-1.
Positive_regulation (induced) of Positive_regulation (upregulation) of N-methyl d-aspartate glutamate receptor 1 associated with ventral tegmentum, glutamate receptor and morphine
18) Confidence 0.06 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.06 Pain Relevance 1.20
The induction of spike timing-dependent LTP requires activation of NMDAR [20,21].
Positive_regulation (requires) of Positive_regulation (activation) of NMDAR in spike associated with long-term potentiation
19) Confidence 0.06 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.08 Pain Relevance 0.48
Acute administration of memantine (10 mg/kg i.p.) induced an upregulation of NR1-1/NR1-2 and NR2B protein levels in the hippocampus and cortex, respectively [219].
Positive_regulation (induced) of in hippocampus Positive_regulation (upregulation) of NR1-1 in cortex associated with hippocampus
20) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.15 Pain Relevance 0.58

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