INT73427

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Context Info
Confidence 0.79
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 8.65
Pain Relevance 9.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
nerve 3
leukocyte 2
glial cells 2
endothelial cells 2
macrophages 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 311 100.00 Very High Very High Very High
Dopamine 219 100.00 Very High Very High Very High
antagonist 200 100.00 Very High Very High Very High
chemokine 134 100.00 Very High Very High Very High
Neurotransmitter 94 100.00 Very High Very High Very High
medulla 54 100.00 Very High Very High Very High
excitatory amino acid 35 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
IPN 42 99.52 Very High Very High Very High
Inflammation 289 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 46 99.52 Very High Very High Very High
INFLAMMATION 332 99.36 Very High Very High Very High
Injury 111 98.80 Very High Very High Very High
Pain 52 98.52 Very High Very High Very High
Status Epilepticus 318 98.24 Very High Very High Very High
Clostridium Difficile Infection 2 97.80 Very High Very High Very High
Nervous System Injury 10 96.28 Very High Very High Very High
Neurological Disease 10 95.40 Very High Very High Very High
Targeted Disruption 29 94.36 High High
Brain Injury 12 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP-sensitive P2X7 receptors are localized on cells of immunological origin including peripheral macrophages and glial cells in the CNS.
Localization (localized) of P2X7 in glial cells
1) Confidence 0.79 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.28 Pain Relevance 0.34
CONCLUSION: Oxidized ATP inhibits inflammatory pain in arthritic rats by inhibition of the P2X7 receptor for ATP, which is localized on nerve terminals.


Localization (localized) of P2X7 receptor in nerve
2) Confidence 0.68 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12483745 Disease Relevance 0 Pain Relevance 0
We hypothesize that oATP, by blocking the P2X7 receptors present on nerves and endothelial cells, could regulate some effects of ATP (having pronociceptive functions when released) on these structures.
Localization (present) of P2X7 in endothelial cells
3) Confidence 0.46 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.31
Moreover, LPS-activated endothelial cells have been shown able to secrete ATP, via P2X7 receptors, and to release IL-l?
Localization (secrete) of P2X7 in endothelial cells
4) Confidence 0.43 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.32 Pain Relevance 0.25
In addition, since P2X7 receptors are localized on many tissue components involved in inflammation, the binding and activation of such receptors by ATP could enable the same structures to release proinflammatory and pronociceptive mediators.
Localization (localized) of P2X7 associated with inflammation
5) Confidence 0.43 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.59 Pain Relevance 0.67
Local treatment with oATP abrogates inflammatory pain possibly by inhibiting P2X7 receptors for ATP which are localized on nerve terminals and on vessels [2,3].
Localization (localized) of P2X7 in vessels associated with ipn
6) Confidence 0.43 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.58 Pain Relevance 0.69
In addition, P2X7 receptor-mediated MCP-1 (released from microglia)/MIP-2 (released from astrocytes) regulation was related to SE-induced leukocyte infiltration in an IL-1?
Localization (released) of P2X7 in leukocyte associated with status epilepticus
7) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2964655 Disease Relevance 0.63 Pain Relevance 0.12
With respect to these P2X7 receptor functions, P2X7-mediated chemokine release is likely involved in neutrophil infiltration, although the mechanisms of neutrophil infiltration into brain parenchyma are still unknown.
Localization (release) of P2X7 in neutrophil associated with chemokine
8) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 1.01 Pain Relevance 0.49
In addition, P2X7 receptor-mediated MCP-1 (released from microglia)/MIP-2 (released from astrocytes) regulation was related to SE-induced leukocyte infiltration in an IL-1?
Localization (released) of P2X7 in leukocyte associated with status epilepticus
9) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2964655 Disease Relevance 0.63 Pain Relevance 0.12
and glutamate, the localization of P2X7 receptors on glial cells, and the growing appreciation for the role of activated glia in promoting the development and maintenance of pathological pain [37–39], it is tempting to regard the P2X7 receptor as a central player in this neuroimmune interface.
Localization (localization) of P2X7 in glial cells associated with pain and glutamate
10) Confidence 0.35 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.94 Pain Relevance 0.71
Eventually, no colocalization of P2X7 and pAkt was observed to this time point (data not shown).
Localization (colocalization) of P2X7
11) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.42 Pain Relevance 0.21
ERK activation was prevented by apyrase and P2 receptor antagonists, suggesting that injury causes release of ATP, which may in turn autocrinally and heterocrinally signal on astrocytes and stimulate ERK1/2 activity.
Localization (apyrase) of P2 receptor in astrocytes associated with antagonist and injury
12) Confidence 0.31 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.44 Pain Relevance 0.13
Furthermore, colocalization of the ecto-P2X7 receptor subtype on caspase-3-positive cells was also documented (Fig. 3g,h).
Localization (colocalization) of ecto-P2X7 receptor
13) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.52 Pain Relevance 0.29
ATP-sensitive P2X7 receptors are localized on cells of immunological origin including peripheral macrophages and glial cells in the CNS.
Localization (localized) of P2X7 in macrophages
14) Confidence 0.27 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18602931 Disease Relevance 0.28 Pain Relevance 0.34
We hypothesize that oATP, by blocking the P2X7 receptors present on nerves and endothelial cells, could regulate some effects of ATP (having pronociceptive functions when released) on these structures.
Localization (present) of P2X7 in nerves
15) Confidence 0.16 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.31
Electrophysiological investigations also proved a P2 receptor-mediated release of excitatory amino acids.
Localization (release) of P2 receptor associated with excitatory amino acid
16) Confidence 0.12 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.05 Pain Relevance 0.49
Based on the above-mentioned studies on P2 receptor-mediated transmitter release, it may be assumed that extracellular ATP alters the behavioral pattern via modulation of the neuronal activity of the NAc and VTA.
Localization (release) of P2 receptor in neuronal associated with ventral tegmentum and nucleus accumbens
17) Confidence 0.11 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.54
Further, the effect of 2-MeSATP was also abolished by the concomitant inhibition of dopamine D1 and D2/3 receptors, suggesting that the enhanced intentional behavior after accumbal injection of an ATP analog may be due to a P2 receptor-mediated dopamine release.
Localization (release) of P2 receptor associated with dopamine
18) Confidence 0.11 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.60
Of all the P2X subunits, only P2X6 and P2X7 colocalized with DCX in the SVZ (Tab. 2).
Localization (colocalized) of P2X7
19) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669296 Disease Relevance 0.19 Pain Relevance 0.03
Kynurenic acid (5 mm; n= 3, data not shown) or P2 receptor antagonist PPADS (1 or 10 mm; n= 4, Fig. 6D) applied on the dorsal surface of the brainstem had no effect on the amplitude of rhythmic glutamate release in the NTS.


Localization (glutamate release) of P2 receptor in dorsal surface associated with medulla, glutamate and antagonist
20) Confidence 0.04 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.67

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