INT73429

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 9.05
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Atp2a2)
Anatomy Link Frequency
CPA 2
plasma 1
cardiac muscle 1
internal 1
external 1
Atp2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 78 95.28 Very High Very High Very High
Action potential 10 93.00 High High
ischemia 201 81.40 Quite High
lidocaine 2 78.68 Quite High
fibrosis 9 72.56 Quite High
qutenza 312 70.56 Quite High
cytokine 4 67.88 Quite High
Inflammation 9 63.44 Quite High
metalloproteinase 1 31.92 Quite Low
action potential duration 6 30.96 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 1938 99.98 Very High Very High Very High
Acidosis 459 99.08 Very High Very High Very High
Diabetes Mellitus 257 98.46 Very High Very High Very High
Nociception 27 93.12 High High
Hypertrophy 98 92.68 High High
Alkalosis 24 90.88 High High
Diabetic Cardiomyopathies 118 85.20 High High
Cardiomyopathy 17 84.92 Quite High
Coronary Artery Disease 51 81.40 Quite High
Cardiovascular Disorder Under Development 12 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect was also attributed to inhibition of SERCA activity by ATP depletion (Jackson and Thayer 2006).
Negative_regulation (inhibition) of SERCA
1) Confidence 0.20 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.45 Pain Relevance 0
The most likely cause of the inhibition of SERCA and PMCA is impaired cellular energy metabolism.
Negative_regulation (inhibition) of SERCA
2) Confidence 0.17 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.33 Pain Relevance 0
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Negative_regulation (inhibition) of SERCA associated with hypoxia
3) Confidence 0.17 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0
The anoxia-induced rise in calcium could also be inhibited by a combination of FCCP plus thapsigargin (100 nM), an irreversible inhibitor of SERCA (n = 4, Fig. 4B), and by FCCP in combination with 25 ?
Negative_regulation (inhibitor) of SERCA associated with hypoxia
4) Confidence 0.17 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0
Inhibition of SERCA under normoxic conditions with either thapsigargin (100 nM) or CPA (10 ?
Negative_regulation (Inhibition) of SERCA in CPA
5) Confidence 0.17 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.48 Pain Relevance 0
Studies looking at the effects of inhibition of SERCA on [Ca2+] levels in the ER itself also reveal a significant background Ca2+ leak from those stores (Solovyova and Verkhratsky 2003).
Negative_regulation (inhibition) of SERCA
6) Confidence 0.17 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.70 Pain Relevance 0
Resveratrol, a potent activator of the cardiac function and the SERCA2 in type 1 diabetes were recently administered to adult male streptozotocin-induced diabetic mice, where the induced diabetes produced a progressive decline in cardiac function associated with markedly reduced SERCA2 and increased collagen deposition.
Negative_regulation (reduced) of SERCA2 associated with diabetes mellitus
7) Confidence 0.16 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.22 Pain Relevance 0.23
Phospholamban is an endogenous inhibitor of SERCA activity in cardiac muscle, especially at low [Ca2+]i, and might contribute to the differences in the decay of the transient between groups.
Negative_regulation (inhibitor) of SERCA in cardiac muscle
8) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.34 Pain Relevance 0.10
This observation indicates that under resting conditions, there is significant cycling of Ca2+ into and out of the ER such that on SERCA inhibition there is a net Ca2+ efflux.
Negative_regulation (inhibition) of SERCA
9) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.65 Pain Relevance 0
We found that while raising external pH to 8.8 caused a 90% inhibition of Ca2+ clearance in Ca2+-containing medium, the effects of alkalinization in Ca2+-free medium were much less pronounced and significant Ca2+ clearance remained even when the SERCA was also inhibited (unpublished results).
Negative_regulation (inhibited) of SERCA in external
10) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.56 Pain Relevance 0
In support of this hypothesis, we noted that when SERCA is inhibited with CPA (10 ?
Negative_regulation (inhibited) of SERCA in CPA
11) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.31 Pain Relevance 0
Anoxia also significantly reduced Ca2+ clearance via both the SERCA and PMCA and substantially slowed Ca2+ recycling from the mitochondrion (probably as a consequence of inhibition of SERCA and PMCA).
Negative_regulation (reduced) of SERCA associated with hypoxia
12) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.18 Pain Relevance 0
We also noted that despite anoxia inhibiting SERCA activity, ER store loading was as effective under anoxic conditions as under control conditions (Fig. 10).
Negative_regulation (inhibiting) of SERCA associated with hypoxia
13) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.30 Pain Relevance 0
Anoxia appeared to inhibit both SERCA- and PMCA-mediated Ca2+ clearance equally.
Negative_regulation (inhibit) of SERCA associated with hypoxia
14) Confidence 0.13 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.43 Pain Relevance 0
Many studies have shown that SERCA activity is down-regulated, and Na/Ca exchange up-regulated, in failing heart cells, both preventing the SR from filling [8,11].
Negative_regulation (regulated) of SERCA in heart
15) Confidence 0.07 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.29 Pain Relevance 0
Moderate inhibition of both SERCA and plasma membrane Ca2+ ATPase (PMCA) pumps occurs fairly rapidly in anoxia and corresponds to decline in cytosolic ATP levels [34, 35].
Negative_regulation (inhibition) of SERCA in plasma associated with hypoxia
16) Confidence 0.06 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.74 Pain Relevance 0.17
In addition to the possibility of enhanced Ca2+ release, acidosis may also reduce Ca2+ reuptake into the ER by inhibiting SERCA.
Negative_regulation (inhibiting) of SERCA associated with acidosis
17) Confidence 0.06 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.60 Pain Relevance 0.05
The cause of the rise in [Ca2+]i in response to anoxia has been described previously and includes inhibition of both SERCA and PMCA as well as enhanced leak of Ca2+ from internal (ER) Ca2+ stores [34].
Negative_regulation (inhibition) of SERCA in internal associated with hypoxia
18) Confidence 0.04 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.75 Pain Relevance 0.04
When both VSRM and ICa-L were available, sigmoidal contraction-voltage relationships became bell-shaped with protocols to reduce SR Ca2+ load.
Negative_regulation (reduce) of SR Ca2
19) Confidence 0.01 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458864 Disease Relevance 0 Pain Relevance 0.07
VSRM contractions were extremely sensitive to ryanodine, thapsigargin, and conditioning protocols to reduce SR Ca2+ load.
Negative_regulation (reduce) of SR Ca2
20) Confidence 0.01 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458864 Disease Relevance 0 Pain Relevance 0.08

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