INT73432

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 21.04
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
heart 3
forelimb 1
brain 1
incisor 1
Nppa (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 23 99.92 Very High Very High Very High
fibrosis 20 99.66 Very High Very High Very High
bradykinin 2 99.50 Very High Very High Very High
alcohol 57 98.28 Very High Very High Very High
Pain 25 94.72 High High
anesthesia 34 91.24 High High
cytokine 14 89.80 High High
Inflammation 74 89.24 High High
agonist 38 70.40 Quite High
ketamine 15 57.52 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 80 100.00 Very High Very High Very High
Fibrosis 30 99.96 Very High Very High Very High
Pneumonia 188 99.64 Very High Very High Very High
Hypertension 16 99.64 Very High Very High Very High
Sprains And Strains 852 99.60 Very High Very High Very High
Hypertrophy 49 98.96 Very High Very High Very High
Hypotension 2 98.72 Very High Very High Very High
Targeted Disruption 65 98.44 Very High Very High Very High
Coronary Heart Disease 109 98.16 Very High Very High Very High
Myocardial Infarction 193 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adult baseline PWL was significantly decreased in CD1 mice exposed to CFA on PND 1 and 14 as compared to their saline treated counterparts.
Gene_expression (exposed) of PND
1) Confidence 0.59 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19665540 Disease Relevance 1.38 Pain Relevance 0.62
On pnd 2, 4, 6 and 8, BTBR pups emitted significantly more calls [strain×age interaction: F(12,144)?
Gene_expression (emitted) of pnd associated with sprains and strains
2) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.88 Pain Relevance 0
On pnd 2, BTBR and B6 pups emitted softer calls than FVB/NJ and 129X1 [strain×age interaction: F(12,144)?
Gene_expression (emitted) of pnd associated with sprains and strains
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.82 Pain Relevance 0
More crying in these babies may be similar to the higher number of separation calls in BTBR pups, that were emitted at louder amplitudes than B6 beginning at pnd 4, and were primarily the harmonic syllable.
Gene_expression (beginning) of pnd
4) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.35 Pain Relevance 0
Post hoc comparisons revealed that BTBR pups showed faster incisor growth between pnd 6 and 12 [strain×age interaction: F(4,72)?
Gene_expression (growth) of pnd in incisor associated with sprains and strains
5) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.54 Pain Relevance 0
On pnd 6 and 8, BTBR pups emitted calls with lower frequency [strain×age interaction: F(12,144)?
Gene_expression (pups) of pnd associated with sprains and strains
6) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.84 Pain Relevance 0
2.3, p<.05; Newman-Keuls p<.001 for BTBR versus B6 at pnd 4, 6, 8 and 12; Newman-Keuls p<.05 at pnd 10; g) forelimb placing: F(5,90)?
Gene_expression (at) of pnd in forelimb
7) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.41 Pain Relevance 0
0.24, p<.001; Newman-Keuls p<.001 for BTBR versus B6 at pnd 6 and 8; f) cliff aversion: F(6,108)?
Gene_expression (versus) of pnd
8) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.45 Pain Relevance 0
05 for BTBR versus B6; Newman-Keuls at pnd 8: p?
Gene_expression (versus) of pnd
9) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.84 Pain Relevance 0
A significant difference was detected between B6 and BTBR pups at pnd 2 and 4 [strain×age interaction: F(6,108)?
Gene_expression (pups) of pnd associated with sprains and strains
10) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516927 Disease Relevance 0.90 Pain Relevance 0
Counteraction of the cardiac Ang II effects by ANP/GC-A/cGMP involves PKG I and RGS2
Gene_expression (/) of ANP
11) Confidence 0.51 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.14 Pain Relevance 0
Counteraction of the cardiac Ang II effects by ANP/GC-A/cGMP involves PKG I and RGS2
Gene_expression (/) of ANP
12) Confidence 0.51 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.14 Pain Relevance 0
To gain new insights into the intracellular signalling pathways mediating the local antihypertrophic effects of ANP/GC-A, we compared the influence of ANP on ?
Gene_expression (/) of ANP
13) Confidence 0.51 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.09 Pain Relevance 0.04
Our data revealed that neither acute ethanol challenge nor ADH transgene affected the hypertrophic marker ANP expression.
Gene_expression (expression) of ANP
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.59 Pain Relevance 0
Atrial natriuretic peptide (ANP), a peptide hormone produced by the heart, exerts a chronic hypotensive effect.
Gene_expression (produced) of ANP in heart associated with natriuresis and hypotension
15) Confidence 0.36 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458926 Disease Relevance 0.53 Pain Relevance 0
Knockout mice with a homozygous disruption of the pro-ANP gene (-/-) are incapable of producing ANP and are hypertensive relative to their wild-type (+/+) siblings.
Gene_expression (producing) of ANP associated with targeted disruption and hypertension
16) Confidence 0.36 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458926 Disease Relevance 0.54 Pain Relevance 0.09
Remarkably, our results also show that depletion of MEF2C attenuated the interstitial fibrosis and the rise of ANP expression, without affecting the left ventricular function, indicating that depletion of MEF2C may reduce the adverse effects of pressure overload.
Gene_expression (expression) of ANP associated with fibrosis
17) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.33 Pain Relevance 0.05
Data from our present study revealed that ADH accentuated ethanol-induced cardiomyocyte hypertrophy with little change in gross weight of the heart or expression of the hypertrophic marker ANP.
Gene_expression (expression) of ANP in heart associated with hypertrophy
18) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.97 Pain Relevance 0.04
-skeletal actin and atrial natriuretic factor in ADH but not FVB mice after 10 weeks of alcohol feeding [23].
Neg (not) Gene_expression (skeletal) of atrial natriuretic factor associated with natriuresis and alcohol
19) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.09 Pain Relevance 0.05
An increase in left ventricular mass, atrial natriuretic factor expression, and histological changes were indicative of cardiac hypertrophy.
Gene_expression (expression) of atrial natriuretic factor associated with natriuresis and coronary heart disease
20) Confidence 0.32 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18599591 Disease Relevance 0.46 Pain Relevance 0.09

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