INT73433

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Context Info
Confidence 0.71
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.74
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100a6) nuclear envelope (S100a6) plasma membrane (S100a6)
nucleus (S100a6) cytoplasm (S100a6)
Anatomy Link Frequency
stroma 2
decidua 2
brain 1
kidney 1
S100a6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 135 91.96 High High
agonist 55 88.40 High High
Osteoarthritis 4 80.32 Quite High
metalloproteinase 4 79.44 Quite High
anesthesia 14 61.80 Quite High
Angina 4 50.00 Quite Low
ketamine 2 46.52 Quite Low
Potency 5 9.80 Low Low
cytokine 27 5.44 Low Low
Abeta 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Conjunctiva Disease 1 99.84 Very High Very High Very High
Breast Cancer 4 98.72 Very High Very High Very High
Hypertension 3 98.68 Very High Very High Very High
Disease 20 97.00 Very High Very High Very High
Pathologic Processes 1 96.52 Very High Very High Very High
Targeted Disruption 51 94.80 High High
Myocardial Infarction 4 92.56 High High
INFLAMMATION 141 91.96 High High
Unstable Angina 4 91.40 High High
Obesity 2 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, S100A6, S100A8, and S100A9 were found to be extensively expressed in pterygium tissue removed from patients [41,42].
Gene_expression (expressed) of S100A6 associated with conjunctiva disease
1) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.84 Pain Relevance 0.17
METHODS: Elderly patients with AMI were retrospectively stratified for the presence and absence of PrA, and for quartiles of BMI and physical activity.
Neg (absence) Gene_expression (absence) of PrA
2) Confidence 0.59 Published 2009 Journal Eur J Cardiovasc Prev Rehabil Section Body Doc Link 19188807 Disease Relevance 0.27 Pain Relevance 0
We conclude that, regardless of the state of alertness, -/- mice develop salt-sensitive hypertension after prolonged feeding on HS, in part due to their inability to reduce PRA, whereas the specific renal upregulation of ecNOS and ET-1 in response to HS intake may be an ANP-independent adaptive adjustment aimed at improving kidney function and counteracting the pressor effect of salt.
Gene_expression (reduce) of PRA in kidney associated with hypertension
3) Confidence 0.33 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458926 Disease Relevance 0.25 Pain Relevance 0.06
S100A6 is also found in the extracellular medium of breast cancer cells.
Gene_expression (found) of S100A6 associated with breast cancer
4) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.57 Pain Relevance 0.08
S100A6 is found primarily in the neurons of restricted regions of the brain [42].
Gene_expression (found) of S100A6 in brain
5) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.57 Pain Relevance 0.08
The differences in results obtained by the two antibodies should though be interpreted with caution, since it is difficult to draw conclusions on the expression of PRA when the affinities of each antibody are not the same.
Gene_expression (expression) of PRA
6) Confidence 0.06 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
In the pregnant animals the stroma and decidua was strongly stained for PRAB, but only faint for PRB, indicating that PRA is the most expressed isoform in this state.
Gene_expression (expressed) of PRA in decidua
7) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.19
From the experiment with E2 and/or P treatment only stroma seems to express PRA in cells not expressing PRB, since in this compartment differences between PRAB and PRB immunostaining are apparent.
Neg (not) Gene_expression (express) of PRA in stroma
8) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.06 Pain Relevance 0
PRA seems to be highly expressed in the decidua.
Gene_expression (expressed) of PRA in decidua
9) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.18 Pain Relevance 0
In the pregnant animals the stroma and decidua was strongly stained for PRAB, but only faint for PRB, indicating that PRA is the most expressed isoform in this state.
Gene_expression (expressed) of PRA in stroma
10) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.19

General Comments

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