INT73434

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.86
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
head 4
myocyte 1
cranial 1
peripheral nerve 1
Nppa (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 129 99.26 Very High Very High Very High
Versed 128 99.04 Very High Very High Very High
Demyelination 74 91.84 High High
Central nervous system 26 88.00 High High
Somatosensory cortex 36 81.04 Quite High
Inflammation 30 80.96 Quite High
Pyramidal cell 24 77.76 Quite High
Hippocampus 12 68.56 Quite High
Multiple sclerosis 18 64.64 Quite High
agonist 10 63.60 Quite High
Disease Link Frequency Relevance Heat
Weight Loss 4 100.00 Very High Very High Very High
Targeted Disruption 14 99.52 Very High Very High Very High
Ataxia 4 98.98 Very High Very High Very High
Tremor 4 98.76 Very High Very High Very High
Paralysis 4 98.48 Very High Very High Very High
Hypotension 1 98.36 Very High Very High Very High
Cerebellar Diseases 2 98.32 Very High Very High Very High
Hypertension 12 97.96 Very High Very High Very High
Death 2 97.32 Very High Very High Very High
Natriuresis 16 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean spine head diameters were significantly reduced following a 5 h midazolam anesthesia at PND 20, and less at PND 30 (mean decrease at PND 15: 35±1.2%; at PND 20: 37±4%; at PND 30: 10±2%; P<0.01, Fig. 1c).
Negative_regulation (decrease) of PND in head associated with anesthesia and versed
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0 Pain Relevance 1.00
Right change in L-type Ca2+ channel current density (I) in percent b after application of 10 nM Ang II, 100 nM ANP or ANP and Ang II (n = 7 cells from 3 mice) and d after application of 100 nM ISO, 100 nM ANP or ANP and ISO (n = 5 cells from 3 mice); *P < 0.05 versus B, basal
Negative_regulation (application) of ANP
2) Confidence 0.32 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
The inhibitory effects of ANP on myocyte Ca2+ responses to Ang II are mediated by GC-A/cGMP/PKG I-dependent modulation of RGS2
Negative_regulation (effects) of ANP in myocyte
3) Confidence 0.32 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
We conclude from these in vivo data that a chronic inhibition of the local, cardiac effects of ANP exacerbates the hypertrophic actions of Ang II, but not of ?
Negative_regulation (effects) of ANP
4) Confidence 0.32 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.64 Pain Relevance 0
Anesthesia-induced changes in spine head diameter, observed following a 5 h midazolam anesthesia at PND 15, was still present at PND 20 (P<0.001) and, although to a lesser extent, also at PND 30 (mean decrease compared to age-matched controls at PND 20: 30±4.5%; at PND 30: 23±2.1%; Fig. 3b).
Negative_regulation (decrease) of PND in head associated with anesthesia and versed
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0.08 Pain Relevance 0.66
Knockout mice with a homozygous disruption of the pro-ANP gene (-/-) are incapable of producing ANP and are hypertensive relative to their wild-type (+/+) siblings.
Negative_regulation (disruption) of ANP associated with targeted disruption and hypertension
6) Confidence 0.26 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458926 Disease Relevance 0.54 Pain Relevance 0.08
Mean spine head diameters were significantly reduced following a 5 h midazolam anesthesia at PND 20, and less at PND 30 (mean decrease at PND 15: 35±1.2%; at PND 20: 37±4%; at PND 30: 10±2%; P<0.01, Fig. 1c).
Negative_regulation (decrease) of PND in head associated with anesthesia and versed
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0 Pain Relevance 1.01
Mean spine head diameters were significantly reduced following a 5 h midazolam anesthesia at PND 20, and less at PND 30 (mean decrease at PND 15: 35±1.2%; at PND 20: 37±4%; at PND 30: 10±2%; P<0.01, Fig. 1c).
Negative_regulation (decrease) of PND in head associated with anesthesia and versed
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0 Pain Relevance 1.02
Twi/twi shows the symptoms of cerebellar dysfunction such as action tremor and ataxia around postnatal day (PND) 25, progressive weight loss after PND 35, and cranial and peripheral nerve palsy, eventually leading to death around PND 45 [4,5].
Negative_regulation (loss) of PND in peripheral nerve associated with tremor, cerebellar diseases, weight loss, ataxia, death and paralysis
9) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.30 Pain Relevance 0.26
Twi/twi shows the symptoms of cerebellar dysfunction such as action tremor and ataxia around postnatal day (PND) 25, progressive weight loss after PND 35, and cranial and peripheral nerve palsy, eventually leading to death around PND 45 [4,5].
Negative_regulation (loss) of PND in cranial associated with tremor, cerebellar diseases, weight loss, ataxia, death and paralysis
10) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.30 Pain Relevance 0.26

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