INT7344

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 132
Total Number 147
Disease Relevance 35.48
Pain Relevance 68.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
neurons 6
gut 5
sperm 4
spinal cord 4
bladder 4
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 1184 100.00 Very High Very High Very High
antagonist 518 100.00 Very High Very High Very High
Inflammation 369 100.00 Very High Very High Very High
Neuropeptide 297 100.00 Very High Very High Very High
Calcitonin gene-related peptide 194 100.00 Very High Very High Very High
agonist 182 100.00 Very High Very High Very High
Pain 145 100.00 Very High Very High Very High
Enkephalin 143 100.00 Very High Very High Very High
Neurotransmitter 87 100.00 Very High Very High Very High
Nerve growth factor 83 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 152 100.00 Very High Very High Very High
Anxiety Disorder 20 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 37 99.72 Very High Very High Very High
Eczema 152 99.56 Very High Very High Very High
Nociception 81 99.36 Very High Very High Very High
INFLAMMATION 356 99.16 Very High Very High Very High
Overactive Bladder 46 99.12 Very High Very High Very High
Diverticulitis 8 99.10 Very High Very High Very High
Hyperalgesia 6 99.04 Very High Very High Very High
Stress 225 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.
Gene_expression (produced) of neurokinin A in jejunum associated with calcitonin gene-related peptide and substance p
1) Confidence 0.75 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3409964 Disease Relevance 0 Pain Relevance 0.36
The distribution of immunoreactive cholecystokinin, substance P, [Met]enkephalin, [Leu]-enkephalin and dynorphin was determined in the cerebral cortex of the human brain post mortem.
Spec (determined) Gene_expression (determined) of substance P in brain associated with dynorphin, enkephalin, cerebral cortex, cholecystokinin and substance p
2) Confidence 0.75 Published 1988 Journal Neuroscience Section Abstract Doc Link 2472575 Disease Relevance 0 Pain Relevance 0.74
SP and NKA exert their main effect on arterial vasomotor tone, whereas NKB is the only tachykinin producing marked dilation of the pulmonary vein.
Gene_expression (producing) of tachykinin in pulmonary vein associated with substance p
3) Confidence 0.75 Published 1989 Journal Life Sci. Section Abstract Doc Link 2481796 Disease Relevance 0.06 Pain Relevance 0.69
At birth, both substance P and dynorphin mRNAs are expressed at high levels in the patches.
Gene_expression (expressed) of substance P associated with dynorphin and substance p
4) Confidence 0.75 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8543654 Disease Relevance 0 Pain Relevance 0.93
In a study to test the hypothesis that defects in the metabolism of neuropeptides might be a contributing factor to human anterior pituitary tumor formation, the proenkephalin A, proopiomelanocortin (POMC), and tachykinin systems, which produce methionine enkephalin (ME), beta-endorphin (BE), and substance P (SP), respectively, were measured in patients who had a wide variety of pituitary tumors.
Gene_expression (produce) of tachykinin in anterior pituitary associated with pituitary cancer, neuropeptide, enkephalin and substance p
5) Confidence 0.75 Published 1993 Journal Biol. Mass Spectrom. Section Abstract Doc Link 8381675 Disease Relevance 0.38 Pain Relevance 0.70
The substance P–related receptor (R), the neurokinin-1 (NK-1) R, is expressed by human keratinocytes, endothelial cells, fibroblasts, and mast cells.
Gene_expression (expressed) of substance P in keratinocytes associated with substance p
6) Confidence 0.75 Published 2008 Journal Journal of the European Academy of Dermatology and Venereology Section Body Doc Link PMC2229631 Disease Relevance 0.50 Pain Relevance 0.82
Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens.
Gene_expression (Expression) of substance P in neurons associated with nucleus accumbens, enkephalin and substance p
7) Confidence 0.75 Published 1998 Journal Neuroscience Section Title Doc Link 9483534 Disease Relevance 0 Pain Relevance 0.68
Although species variations exist, NK-2 receptors are generally present on the musculature, NK-1 receptors on both neurons and muscles, and NK-3 receptors on neurons only.
Gene_expression (present) of NK-2 in muscles
8) Confidence 0.75 Published 2000 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 11130458 Disease Relevance 0 Pain Relevance 0.20
An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres.
Gene_expression (expressed) of substance P in nucleus associated with substance p
9) Confidence 0.75 Published 2002 Journal Cephalalgia Section Title Doc Link 12133041 Disease Relevance 0 Pain Relevance 0.46
At the same time, the plasma levels of calcitonin gene-related peptide (CGRP), neurokinin A (NKA), prostaglandin E2 (PGE2) and 6 keto PGF1alpha, the stable product of PGI2, were assessed with radioimmunoassay (RIA) kits in the same samples.
Gene_expression (levels) of neurokinin A in PGE2 associated with calcitonin gene-related peptide
10) Confidence 0.75 Published 2000 Journal Cephalalgia Section Abstract Doc Link 11304026 Disease Relevance 0.39 Pain Relevance 0.61
Expression of neurokinin NK(1) receptors in the spinal cord was enhanced at 12 weeks.
Gene_expression (Expression) of neurokinin in spinal cord
11) Confidence 0.75 Published 2008 Journal Gut Section Body Doc Link 18194988 Disease Relevance 0.06 Pain Relevance 0
Results showed that indomethacin significantly reduced nociception-related peripheral edema, hyperalgesia, and reversed the pain-evoked up-regulation of neurokinin (NK)-1 receptor and brain-derived neurotrophic factor (BDNF) gene expression in the spinal cord to levels not statistically different from controls.
Gene_expression (expression) of neurokinin in spinal cord associated with nociception, pain, pressure and volume under development, hyperalgesia and spinal cord
12) Confidence 0.75 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.47 Pain Relevance 1.47
Future studies should precisely confirm whether the expression of dynorphin/substance P and enkephalin is also restricted to EGFP labeled neurons in drd1a-EGFP and drd2-EGFP mice, respectively.
Spec (whether) Gene_expression (expression) of substance P in neurons associated with dynorphin, enkephalin and substance p
13) Confidence 0.75 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.07 Pain Relevance 0.36
The de novo expression of neurokinin1 receptors on postsynaptic dorsal column neurons after colon inflammation suggests that substance P released from visceral primary afferents under inflammatory conditions could help produce central sensitization of these neurons.
Gene_expression (expression) of neurokinin1 in dorsal associated with central sensitization, inflammation, substance p and dorsal column
14) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 12559111 Disease Relevance 0.42 Pain Relevance 0.80
Perhaps one of the most surprising findings during the last 15 years has been the understanding that expression of neurokinin receptors on leukocyte populations can be constitutive or inducible.
Gene_expression (expression) of neurokinin in leukocyte
15) Confidence 0.75 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15358592 Disease Relevance 0.13 Pain Relevance 0.24
Recombinant cell lines expressing neurokinin receptors and apoaequorin were used in the study.
Gene_expression (expressing) of neurokinin
16) Confidence 0.75 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15990182 Disease Relevance 0 Pain Relevance 0.17
The organization of the cholinergic fiber system was compared with that of striatal systems expressing immunoreactivity for calbindin D28k, met-enkephalin, substance P, tyrosine hydroxylase, and parvalbumin.
Gene_expression (expressing) of substance P associated with enkephalin and substance p
17) Confidence 0.75 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9214537 Disease Relevance 0 Pain Relevance 0.31
We also evaluated the levels of nerve growth factor, substance P and enkephalins in the cerebrospinal fluid of these patients.
Gene_expression (levels) of substance P in cerebrospinal fluid associated with nerve growth factor, enkephalin and substance p
18) Confidence 0.75 Published 2010 Journal Eur J Cancer Care (Engl) Section Abstract Doc Link 19490010 Disease Relevance 1.22 Pain Relevance 0.77
IMPLICATIONS: We investigated the effects of IV anesthetics on substance P receptors (SPR) expressed in Xenopus oocytes.
Gene_expression (expressed) of substance P in oocytes associated with substance p
19) Confidence 0.75 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12818951 Disease Relevance 0 Pain Relevance 0.72
In addition, levels of the neuropeptides substance P and somatostatin were determined.
Gene_expression (levels) of substance P associated with somatostatin, neuropeptide and substance p
20) Confidence 0.75 Published 1996 Journal Schmerz Section Abstract Doc Link 12799848 Disease Relevance 0.49 Pain Relevance 0.86

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