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Context Info
Confidence 0.05
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.87
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pilra)
Anatomy Link Frequency
blood 2
neurons 1
eosinophils 1
myotubes 1
Pilra (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 16 100.00 Very High Very High Very High
tetrodotoxin 3 99.08 Very High Very High Very High
Morphine 2 98.98 Very High Very High Very High
cytokine 75 97.66 Very High Very High Very High
Inflammation 96 92.36 High High
Kappa opioid receptor 24 68.84 Quite High
cINOD 119 66.72 Quite High
agonist 26 42.60 Quite Low
imagery 5 40.08 Quite Low
Thalamus 8 33.24 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 85 98.68 Very High Very High Very High
Amyloid Plaque 47 98.60 Very High Very High Very High
Death 42 98.12 Very High Very High Very High
Targeted Disruption 196 96.92 Very High Very High Very High
INFLAMMATION 112 92.36 High High
Atherosclerosis 29 88.12 High High
Diabetes Mellitus 52 87.32 High High
Disease 189 86.32 High High
Alzheimer's Dementia 167 85.28 High High
Disorder Of Lipid Metabolism 6 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LRP is an endocytotic cell-surface receptor that is abundant in neurons (cell body and dendrites).
Gene_expression (abundant) of cell-surface receptor in neurons
1) Confidence 0.05 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.84 Pain Relevance 0.09
A study in mice lacking the chemokine receptor 2, a microglial cell-surface receptor that mediates recruitment of blood-derived microglia, supports the idea that bone marrow-derived macrophages infiltrate the brain and can clear A?
Neg (lacking) Gene_expression (lacking) of cell-surface receptor in blood associated with chemokine
2) Confidence 0.05 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.33 Pain Relevance 0.27
Interleukins are a wide spectrum of small regulatory protein molecules encompassed in the family of cytokines, exerting their effects via gene activation that leads to cellular stimulation, growth, differentiation, functional cell-surface receptor expression, and cellular effector function.
Gene_expression (expression) of cell-surface receptor associated with cytokine
3) Confidence 0.02 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.86 Pain Relevance 0.13
Therefore, we performed an analysis of cell-surface receptor expression in parallel with the cAMP response experiment.
Gene_expression (expression) of cell-surface receptor
4) Confidence 0.01 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.07
Surface receptor expression tracked mRNA expression forall types of nuclear topology observed, indicating that message levels are in fact reliable indicators of receptor population on the plasma membrane surface in myotubes.
Gene_expression (expression) of Surface receptor in myotubes
5) Confidence 0.01 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.20

Fas (CD95, APO-1) is a cell surface receptor expressed on many cells including eosinophils, which mediates apoptosis when ligated by agonistic antibodies or its natural ligand FasL.

Gene_expression (expressed) of surface receptor in eosinophils associated with apoptosis
6) Confidence 0.01 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.84 Pain Relevance 0.04
We investigated whether morphine and fentanyl influence CD 11b and CD35 surface receptor expression, phagocytic activity and superoxide anion generation of monocytes in a whole blood flow cytometric assay.
Gene_expression (expression) of surface receptor in blood associated with morphine
7) Confidence 0.01 Published 2004 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 15098168 Disease Relevance 0 Pain Relevance 0.17

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