INT73451

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Context Info
Confidence 0.48
First Reported 1998
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
muscle cells 2
bladder 2
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 92.76 High High
qutenza 1 10.00 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results indicate that nicotinic acetylcholine receptor activation in capsaicin sensitive C-fiber afferents in the bladder can induce detrusor overactivity.
Positive_regulation (induce) of Positive_regulation (activation) of nicotinic acetylcholine receptor in bladder
1) Confidence 0.48 Published 2006 Journal J. Urol. Section Body Doc Link 16753446 Disease Relevance 0 Pain Relevance 0
To determine whether mRNA expression was transient and did not result in steady-state upregulation of AChR receptor protein, we performed a double labeling of surface AChRs with 125I-alpha-bungarotoxin (125I-alpha-BTX) concomitant to the in situ hybridization for mRNA quantification on TTX treated muscle cells.
Neg (not) Spec (whether) Positive_regulation (result) of Spec (whether) Positive_regulation (upregulation) of AChR in muscle cells associated with tetrodotoxin
2) Confidence 0.07 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.22

General Comments

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