INT7346

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.78
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
plasma 1
choroid plexus 1
afferent neurons 1
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 58 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
qutenza 13 99.32 Very High Very High Very High
cINOD 10 99.26 Very High Very High Very High
Central nervous system 3 99.12 Very High Very High Very High
anesthesia 3 98.54 Very High Very High Very High
peptic ulcer disease 11 98.36 Very High Very High Very High
anticonvulsant 1 98.20 Very High Very High Very High
beta blocker 1 97.52 Very High Very High Very High
headache 4 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 30 98.36 Very High Very High Very High
Disease 27 97.84 Very High Very High Very High
Diarrhoea 3 96.92 Very High Very High Very High
Constipation 2 96.36 Very High Very High Very High
Dizziness 1 95.80 Very High Very High Very High
Headache 4 95.36 Very High Very High Very High
Stomach Cancer 1 93.48 High High
Hemorrhage 6 92.64 High High
Thrombocytopenia 1 91.80 High High
Hyperplasia 3 90.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-sensitive vagal afferent fibers do not contribute to histamine H2 receptor agonist-induced gastric acid secretion in anesthetized rats.
Localization (secretion) of H2 receptor associated with qutenza and agonist
1) Confidence 0.69 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 2149706 Disease Relevance 0.09 Pain Relevance 0.68
Proton pump inhibitors are more potent inhibitors of acid secretion than H2-receptor antagonists.
Localization (secretion) of H2-receptor associated with antagonist
2) Confidence 0.67 Published 1996 Journal Clin Ther Section Abstract Doc Link 8851451 Disease Relevance 0.96 Pain Relevance 0.24
Thus, famotidine is a safe and potent H2-receptor blocker of acid secretion.
Localization (secretion) of H2-receptor
3) Confidence 0.61 Published 1987 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 2908767 Disease Relevance 0.44 Pain Relevance 0.27
Some of the H2-receptor antagonists are actively secreted by the renal tubules and may thus compete with other drugs for cationic tubular transport mechanisms, resulting in reduced urinary excretion and hence potentially toxic plasma concentrations.
Localization (secreted) of H2-receptor in plasma associated with antagonist
4) Confidence 0.59 Published 1986 Journal Med Toxicol Section Abstract Doc Link 2878343 Disease Relevance 0.07 Pain Relevance 0.30
Ranitidine, a histamine H2-receptor antagonist, is now well established as a potent inhibitor of gastric acid secretion effective in the treatment and prophylaxis of gastrointestinal lesions aggravated by gastric acid secretion.
Localization (secretion) of H2-receptor associated with antagonist
5) Confidence 0.56 Published 1989 Journal Drugs Section Abstract Doc Link 2667937 Disease Relevance 0.58 Pain Relevance 0.21
Drugs that inhibit or neutralize gastric acid secretion include histamine H2-receptor antagonists, proton pump inhibitors, anticholinergics, prostaglandins, and antacids.
Localization (secretion) of H2-receptor associated with antagonist
6) Confidence 0.56 Published 1992 Journal J Assoc Acad Minor Phys Section Abstract Doc Link 1353999 Disease Relevance 1.57 Pain Relevance 0.38
The late 1970s saw the introduction of histamine2-receptor antagonists (H2RAs), which partially suppress basal and meal-stimulated acid secretion.
Localization (secretion) of histamine2-receptor associated with antagonist
7) Confidence 0.53 Published 2003 Journal Pharmacotherapy Section Abstract Doc Link 14587958 Disease Relevance 0.26 Pain Relevance 0.05
Standard doses of currently available H2-receptor antagonists permit acid secretion in response to food and other stimuli, and this daily acid tide prevents persistent bacterial colonization.
Localization (secretion) of H2-receptor associated with antagonist
8) Confidence 0.48 Published 1993 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 8103374 Disease Relevance 0.43 Pain Relevance 0.26
Effect of lafutidine, a histamine H2-receptor antagonist, on gastric mucosal blood flow and duodenal HCO3- secretion in rats: relation to capsaicin-sensitive afferent neurons.
Localization (secretion) of H2-receptor in afferent neurons associated with qutenza and antagonist
9) Confidence 0.42 Published 2002 Journal Dig. Dis. Sci. Section Title Doc Link 12498288 Disease Relevance 0 Pain Relevance 0.47
Control of gastric acid secretion.
Localization (secretion.) of H2-receptor
10) Confidence 0.32 Published 1992 Journal Gastroenterol. Clin. North Am. Section Title Doc Link 1355465 Disease Relevance 0 Pain Relevance 0.13
The synthesis and action of H2-receptor antagonists changed the understanding of gastric acid secretion as well as changing medical therapy for peptic ulcer disease.
Localization (secretion) of H2-receptor associated with peptic ulcer disease, antagonist and disease
11) Confidence 0.31 Published 1993 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 8387826 Disease Relevance 0.20 Pain Relevance 0.15
Because the H2-receptor antagonists elevate gastric pH, bind to and inhibit the hepatic cytochrome P-450 enzyme system, and undergo renal tubular secretion, competition with other drugs sharing these pathways has resulted in a number of drug interactions, most of which are not clinically significant.
Localization (secretion) of H2-receptor associated with antagonist
12) Confidence 0.15 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895455 Disease Relevance 0.36 Pain Relevance 0.36
Following a recent report that epithelial cells of the choroid plexus possess histamine H2 receptors, the effect of cimetidine and ranitidine, histamine H2 receptor antagonists, on the secretion and electrolyte content of CSF was examined.
Localization (secretion) of histamine H2 receptor in choroid plexus associated with antagonist
13) Confidence 0.11 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1347778 Disease Relevance 0 Pain Relevance 0.17
We also discuss current alternative approaches being taken to mitigate the GI side-effects of NSAIDs, including developing combination drugs where NSAIDs are packaged with inhibitors of HCl secretion such as proton pump inhibitors or H2-receptor antagonists.
Localization (secretion) of H2-receptor associated with antagonist and cinod
14) Confidence 0.04 Published 2009 Journal Drugs Today Section Abstract Doc Link 20135022 Disease Relevance 0.63 Pain Relevance 0.89
Reduction of acid secretion caused by H2-receptor antagonists is less pronounced and lasts less time than that caused by PPIs, but H2-receptor antagonists are better for the immediate relief of symptoms.2,8
Localization (secretion) of H2-receptor associated with antagonist
15) Confidence 0.04 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963162 Disease Relevance 0.19 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox