INT73460

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 20.44
Pain Relevance 2.61

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nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
keratinocytes 12
skin 6
SNU-1 4
nerve 2
neurons 2
Myc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
qutenza 28 99.84 Very High Very High Very High
cytokine 11 98.16 Very High Very High Very High
Kinase C 130 83.44 Quite High
fibrosis 1 83.12 Quite High
tetrodotoxin 54 81.28 Quite High
Central nervous system 2 76.52 Quite High
addiction 20 73.92 Quite High
agonist 85 64.92 Quite High
metalloproteinase 61 46.08 Quite Low
Disease Link Frequency Relevance Heat
Cancer 223 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 8 99.62 Very High Very High Very High
Bullous Skin Disease 3040 99.60 Very High Very High Very High
Ovarian Cancer 84 99.44 Very High Very High Very High
Acantholysis 650 98.84 Very High Very High Very High
Stomach Cancer 6 98.76 Very High Very High Very High
Suicidal Behaviour 2 98.32 Very High Very High Very High
Death 25 98.28 Very High Very High Very High
Apoptosis 224 98.06 Very High Very High Very High
Repression 22 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As outlined above, PV-IgG-induced plakoglobin depletion resulted in c-Myc overexpression in cultured keratinocytes (Muller et al. 2008a; Williamson et al. 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in keratinocytes associated with bullous skin disease
1) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.14 Pain Relevance 0.06
Moreover, altered plakoglobin signalling leading to c-Myc overexpression was found in PV patients’s skin but not in PF (Williamson et al. 2007, 2006).
Positive_regulation (leading) of Gene_expression (overexpression) of c-Myc in skin associated with bullous skin disease
2) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 2.20 Pain Relevance 0.11
However, the findings that c-Myc overexpression was found after 24 h, whereas PV-IgG-induced loss of cell aggregation was observed as early as after 12 h and that c-Myc overexpression was absent in PF skin indicate that c-Myc overexpression likely contributes to ongoing proliferation of keratinocytes in PV, whereas it seems not to be essential for acantholysis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in keratinocytes associated with acantholysis and bullous skin disease
3) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.28 Pain Relevance 0
Accordingly, c-Myc overexpression was found in the epidermis of PV patients, but interestingly not in PF skin, indicating that this mechanism may only be important for PV (Williamson et al. 2007, 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in skin associated with bullous skin disease
4) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.17 Pain Relevance 0.06
Moreover, following obstruction of the bladders of animal models and patients with BPH, there were acute increases in the expression of bFGF (7), the transcription factors, upstream binding factor, c-Jun, and cyclins E and C (8), nerve growth factor (9), N-ras and c-myc (10), and decreased expression of TGF-beta 1 (7).
Positive_regulation (increases) of Gene_expression (expression) of c-myc in nerve associated with benign prostatic hypertrophy and nerve growth factor
5) Confidence 0.67 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.74 Pain Relevance 0.09
However, the findings that c-Myc overexpression was found after 24 h, whereas PV-IgG-induced loss of cell aggregation was observed as early as after 12 h and that c-Myc overexpression was absent in PF skin indicate that c-Myc overexpression likely contributes to ongoing proliferation of keratinocytes in PV, whereas it seems not to be essential for acantholysis.
Positive_regulation (overexpression) of Neg (absent) Gene_expression (overexpression) of c-Myc in keratinocytes associated with acantholysis and bullous skin disease
6) Confidence 0.67 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.30 Pain Relevance 0
However, the findings that c-Myc overexpression was found after 24 h, whereas PV-IgG-induced loss of cell aggregation was observed as early as after 12 h and that c-Myc overexpression was absent in PF skin indicate that c-Myc overexpression likely contributes to ongoing proliferation of keratinocytes in PV, whereas it seems not to be essential for acantholysis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in keratinocytes associated with acantholysis and bullous skin disease
7) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.29 Pain Relevance 0
A target gene of Lef-1/plakoglobin signalling is c-Myc, the expression of which was inhibited in keratinocytes but enhanced in transformed rat kidney epithelial cells (Kolligs et al. 2000; Kolly et al. 2007; Williamson et al. 2006).
Positive_regulation (enhanced) of Gene_expression (expression) of c-Myc in epithelial cells
8) Confidence 0.49 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.27 Pain Relevance 0
Our results suggest that CAP induces apoptotic cell death in human gastric cancer cells (SNU-1) in vitro which may be possibly mediated by the overexpression of p53 and/or c-myc genes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-myc in SNU-1 associated with qutenza, apoptosis, stomach cancer and death
9) Confidence 0.49 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.10 Pain Relevance 0.79
In our study, de- ATSC overexpressed not only Oct-4, Sox-2, Nanog, and Rex-1, but also c-Myc for the acquisition of active self-renewal activity with pluripotency.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of c-Myc
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.23 Pain Relevance 0
Downregulation of let-7c stabilizes c-Myc mRNA leading to the expression of c-Myc target genes.
Positive_regulation (leading) of Gene_expression (expression) of c-Myc
11) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.67 Pain Relevance 0
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-myc in SNU-1 associated with qutenza and cancer
12) Confidence 0.49 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.18 Pain Relevance 1.01
A recent study [9] used mouse EOC cells (deletion of p53, or overexpression of c-myc/K-ras or c-myc/Akt) to demonstrate increased expression of COX-1 in these genetically engineered EOC cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-myc associated with ovarian cancer
13) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.79 Pain Relevance 0
A recent study [9] used mouse EOC cells (deletion of p53, or overexpression of c-myc/K-ras or c-myc/Akt) to demonstrate increased expression of COX-1 in these genetically engineered EOC cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-myc associated with ovarian cancer
14) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.79 Pain Relevance 0
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Positive_regulation (increase) of Gene_expression (expression) of c-myc
15) Confidence 0.45 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
As outlined above, it has been shown that plakoglobin is involved in c-Myc repression, which is required for keratinocyte differentiation and that PV-IgG by depleting noncytokeratin-anchored plakoglobin on the cell surface also led to c-Myc overexpression (Williamson et al. 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in keratinocyte associated with repression and bullous skin disease
16) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.06 Pain Relevance 0
CONCLUSIONS: Our data thus indicate that NS-398 causes an increase in APC expression and a decrease in c-myc expression.


Positive_regulation (causes) of Gene_expression (expression) of c-myc
17) Confidence 0.45 Published 2002 Journal J. Gastroenterol. Section Body Doc Link 11931531 Disease Relevance 0 Pain Relevance 0
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Positive_regulation (increased) of Gene_expression (expression) of c-myc
18) Confidence 0.45 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.85 Pain Relevance 0.14
It has been shown that autoantibodies from pemphigus vulgaris patients induce continuing keratinocyte proliferation by impaired Dsg 3/plakoglobin signalling, which finally leads to c-Myc overexpression (Muller et al. 2008a; Williamson et al. 2007, 2006).
Positive_regulation (leads) of Gene_expression (overexpression) of c-Myc in keratinocyte associated with bullous skin disease
19) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.27 Pain Relevance 0.04
Moreover, altered plakoglobin signalling leading to c-Myc overexpression was found in PV patients’s skin but not in PF (Williamson et al. 2007, 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of c-Myc in skin associated with bullous skin disease
20) Confidence 0.45 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 2.20 Pain Relevance 0.11

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