INT73463

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.59
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
Anatomy Link Frequency
blood 2
SNU-1 2
central nervous system 2
T-cell 2
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 32 99.98 Very High Very High Very High
qutenza 14 99.84 Very High Very High Very High
cytokine 15 99.48 Very High Very High Very High
Central nervous system 2 96.72 Very High Very High Very High
Angina 13 82.92 Quite High
Paracetamol 1 79.72 Quite High
headache 21 79.08 Quite High
rheumatoid arthritis 7 63.80 Quite High
palliative 5 48.68 Quite Low
Inflammatory response 4 42.84 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1131 100.00 Very High Very High Very High
Chromosome Aberrations 9 99.96 Very High Very High Very High
Hypertension 46 99.48 Very High Very High Very High
Carcinoma 19 99.16 Very High Very High Very High
Congenital Anomalies 31 98.92 Very High Very High Very High
Cervical Cancer 47 98.72 Very High Very High Very High
Apoptosis 129 97.28 Very High Very High Very High
Liver Cancer 10 96.48 Very High Very High Very High
INFLAMMATION 35 95.84 Very High Very High Very High
Brain Tumor 1 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other mutations can occur at Domain B in conjunction with the YMDD mutations. [52] Liaw showed that the cumulative rates of LAM resistance were 14%, 38%, 49%, 66% and 69%, one, two, three, four, and five years after initial therapy respectively. [53] Other studies have showed similar rates of resistance with resistance rates of 24% and 70% after one and four years of therapy respectively. [50,51,54]
Positive_regulation (cumulative) of Gene_expression (resistance) of LAM
1) Confidence 0.38 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.58 Pain Relevance 0
For example, we found an increased expression of the oncogenic miR-21 in B-DIM treated Colo-357 which was unexpected, whereas most of the results displayed decreased expression of oncogenic miRNAs and increased expression of tumor suppressor miRNAs upon treatment with either agent, clearly supporting the role of B-DIM or G2535 as cancer preventing agents.
Positive_regulation (increased) of Gene_expression (expression) of tumor suppressor associated with cancer
2) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.48 Pain Relevance 0
Treatment of Panc-1 with G2535 elicited decreased expression of the oncogenic miRNAs miR-17, miR-20a, miR-106a, miR-222 and increased expression of the tumor suppressor miRNAs let-7a, let-7d, let-7e and let-7f.
Positive_regulation (increased) of Gene_expression (expression) of tumor suppressor associated with cancer
3) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.56 Pain Relevance 0
Conversely, increased expression of tumor suppressor miRNAs would most likely affect cellular processes in a similar manner, adding to the anti-cancer effects of these agents.
Positive_regulation (increased) of Gene_expression (expression) of tumor suppressor associated with cancer
4) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.97 Pain Relevance 0
The historical focus of much of this research has been to identify and study the role of specific genetic abnormalities in tumor cells related to chromosomal abnormalities, inactivation of specific tumor suppressor genes, the activation of specific oncogenes, the expression of hormone receptors and growth factor production associated with the development of cancer.
Positive_regulation (inactivation) of Gene_expression (expression) of tumor suppressor associated with chromosome aberrations, cancer and congenital anomalies
5) Confidence 0.04 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.12 Pain Relevance 0
The von Hippel-Lindau protein (pVHL) is the product of the VHL gene, a tumor-suppressor gene known to be inactivated in renal clear-cell carcinomas as well as other markedly vascular tumors such as central nervous system hemangioblastoma [24].
Positive_regulation (inactivated) of Gene_expression (product) of tumor-suppressor in central nervous system associated with cancer, carcinoma, central nervous system and brain tumor
6) Confidence 0.02 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 0.62 Pain Relevance 0.05
The first observations on DNA demethylation as a hydralazine off-target effect were performed in 1988 in the course of experiments to prove that this drug could induce self-reactivity in cloned T-cell lines and DNA hypomethylation [167], followed by reports on its ability to restore expression of tumor suppressor genes silenced by promoter hypermethylation in cancer cell lines and primary tumors [168-171].
Positive_regulation (restore) of Gene_expression (expression) of tumor suppressor in T-cell associated with cancer
7) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.30 Pain Relevance 0.16
These pre-clinical studies were the foundation for performing a phase I study to investigate whether hydralazine administered by oral route at doses commonly used for treatment of high blood pressure could demethylate and re-activate tumor suppressor gene expression in the tumors of patients with cervical cancer [98].
Positive_regulation (activate) of Gene_expression (expression) of tumor suppressor in blood associated with cervical cancer, cancer and hypertension
8) Confidence 0.02 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.02 Pain Relevance 0
Within this class of so-called "non-toxic and orally administered agents", there is the green tea major polyphenol (-)-epigallocatechin-3-gallate (EGCG) that demonstrated to be an effective DNMT activity inhibitor at micromolar concentrations and that was able to demethylate and reactivate expression of several tumor suppressor genes such as p16, RAR-?
Positive_regulation (reactivate) of Gene_expression (expression) of tumor suppressor associated with cancer
9) Confidence 0.02 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.68 Pain Relevance 0
These observations, unrelated to the field of DNA methylation in cancer and demonstrating that hydralazine possesses DNA demethylating activity [82], led to testing the hypothesis that hydralazine, by virtue of its DNA methylation inhibitory activity, could restore tumor suppressor gene re-expression by relieving hypermethylation at the gene promoter.
Positive_regulation (restore) of Gene_expression (expression) of tumor suppressor associated with cancer
10) Confidence 0.02 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.72 Pain Relevance 0.03
Among non-nucleoside DNA demethylating drugs currently under development, the oral drug hydralazine possess the ability to reactivate tumor suppressor gene expression, which is silenced by promoter hypermethylation in vitro and in vivo.
Positive_regulation (reactivate) of Gene_expression (expression) of tumor suppressor associated with cancer
11) Confidence 0.02 Published 2006 Journal J Transl Med Section Abstract Doc Link PMC1413557 Disease Relevance 0.82 Pain Relevance 0
Existing data show that this agent is able to demethylate and re-activate tumor suppressor gene expression in patients with cancer.
Positive_regulation (activate) of Gene_expression (expression) of tumor suppressor associated with cancer
12) Confidence 0.02 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.54 Pain Relevance 0
Hydralazine at doses between 50 and 150 mg/day is well tolerated and effective to demethylate and reactivate the expression of tumor suppressor genes without affecting global DNA methylation



Positive_regulation (reactivate) of Gene_expression (expression) of tumor suppressor associated with cancer
13) Confidence 0.02 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1131894 Disease Relevance 0.76 Pain Relevance 0.08
A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes

Background

Positive_regulation (reactivate) of Gene_expression (expression) of tumor suppressor associated with cancer
14) Confidence 0.02 Published 2005 Journal BMC Cancer Section Title Doc Link PMC1131894 Disease Relevance 0.75 Pain Relevance 0.06
The carcinogenic response is based on enhanced cell replication that might increase the risk for DNA damage and altered oncogene and tumor suppressor gene expressions.
Positive_regulation (increase) of Gene_expression (expressions) of tumor suppressor associated with cancer
15) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.98 Pain Relevance 0
Consequently, SNU-1 cells are sensitive to CAP in the overexpression of tumor suppressor gene, p53 and proto-oncogenes, c-myc and c-Ha-ras, but not those of c-erbB-2, c-jun and bcl-2 genes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of tumor suppressor gene in SNU-1 associated with qutenza and cancer
16) Confidence 0.01 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 1.17 Pain Relevance 1.00
If the tumor suppressor genes are overexpressed or activated, at least two cancer preventative pathways may result, one from the activity of the group 11A tumor suppressor [Reviewed in [39]] and a second from the AA released.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of tumor suppressor associated with cancer
17) Confidence 0.01 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 0.59 Pain Relevance 0
We selected two potential transcriptional targets of Tsc-22, growth arrest and DNA damage-inducible gene 45 beta (Gadd45b) and leucine zipper, putative tumor suppressor 2 (Lzts2) to test based on our previous complementary DNA microarray studies, showing that expression of these cancer-associated genes was increased when Tsc-22 was repressed.
Positive_regulation (increased) of Gene_expression (expression) of tumor suppressor associated with cancer
18) Confidence 0.00 Published 2007 Journal Toxicol. Sci. Section Abstract Doc Link 17533171 Disease Relevance 0.51 Pain Relevance 0.08
Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein.
Positive_regulation (induce) of Gene_expression (expression) of tumor suppressor associated with cancer and cytokine
19) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Title Doc Link 15509713 Disease Relevance 0.20 Pain Relevance 0.97
Thus, NSAIDs induce the expression of EGR-1, a tumor suppressor gene, providing a novel mechanism to explain, in part, the antitumorigenic properties of some NSAIDs.
Positive_regulation (induce) of Gene_expression (expression) of tumor suppressor associated with cancer and cinod
20) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15509713 Disease Relevance 0.23 Pain Relevance 1.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox