INT73475

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.46
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
thyroid 2
nucleus 2
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 99.76 Very High Very High Very High
Paracetamol 10 98.64 Very High Very High Very High
Eae 2 87.80 High High
tolerance 4 64.00 Quite High
cINOD 2 60.20 Quite High
Inflammation 2 59.32 Quite High
fibrosis 2 54.64 Quite High
carbamazepine 8 7.80 Low Low
Clonidine 2 7.08 Low Low
depression 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 55 99.18 Very High Very High Very High
Thyroid Neoplasm 94 98.70 Very High Very High Very High
Carcinoma 3 98.42 Very High Very High Very High
Apoptosis 42 97.80 Very High Very High Very High
Cervical Cancer 2 96.48 Very High Very High Very High
Alagille Syndrome 3 95.00 High High
Targeted Disruption 3 93.88 High High
Myeloid Leukemia 16 90.64 High High
Basal And Squamous Cell Skin Cancer 71 89.12 High High
Infection 17 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin ubiquitination led to its translocation into the nucleus, and resultant upregulation of c-myc transcription.
Positive_regulation (upregulation) of Transcription (transcription) of c-myc in nucleus
1) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.60 Pain Relevance 0.08
Morphine at concentrations of 10(-12) M to 10(-10) M also modulated mRNA expression of early growth related genes (c-fos, c-jun and c-myc).
Positive_regulation (modulated) of Transcription (expression) of c-myc associated with morphine
2) Confidence 0.49 Published 1998 Journal Kidney Int. Section Abstract Doc Link 9461094 Disease Relevance 0.49 Pain Relevance 0.77
In MKN28 cells, the levels of p53, p21waf1/cip1, and c-myc mRNA remained unchanged over the 24-hr treatment with indomethacin, but the p53 protein level was elevated after 4 hr.
Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of c-myc
3) Confidence 0.49 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.93 Pain Relevance 0.12
For the c-MYC gene, we found no significant effect of paracetamol on the repair of CPDs, possibly because UV-irradiation is known to induce transcription of the c-MYC gene and enhanced transcription coupled repair might counteract a negative effect of paracetamol on global genome repair.
Positive_regulation (induce) of Transcription (transcription) of c-MYC gene associated with paracetamol
4) Confidence 0.45 Published 1998 Journal Chem. Biol. Interact. Section Abstract Doc Link 9566729 Disease Relevance 0 Pain Relevance 0.65
Although no evidence for gene rearrangements or amplification of the nuclear proto-oncogenes has been noted in thyroid carcinomas, in human MTC samples, both a high frequency of c-myc allelic losses [50] and elevated levels of c-myc and c-jun mRNA have been demonstrated [52].
Positive_regulation (elevated) of Transcription (levels) of c-myc in thyroid associated with thyroid neoplasm and carcinoma
5) Confidence 0.45 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.89 Pain Relevance 0
Under VPA treatment, transcription of c-myc is dependent upon JNK/SAPK, and ectopic expression of c-myc, leading to more resistant cells in cell cycle arrest, shows the importance of this protein in VPA-mediated activity.
Positive_regulation (dependent) of Transcription (transcription) of c-myc
6) Confidence 0.45 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.67 Pain Relevance 0.06
The main function of HPV integration is considered to be for the stabilization of viral oncogene transcription [26, 27].
Positive_regulation (stabilization) of Transcription (transcription) of viral oncogene associated with papillomavirus infection
7) Confidence 0.00 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.87 Pain Relevance 0

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