INT73476

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.14
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYC) chromosome organization (MYC) nucleolus (MYC)
nucleus (MYC) DNA binding (MYC) protein complex (MYC)
Anatomy Link Frequency
thyroid 2
nucleus 1
T-cell 1
MYC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 9 99.76 Very High Very High Very High
Paracetamol 10 98.50 Very High Very High Very High
Eae 2 87.16 High High
Inflammation 56 84.76 Quite High
cINOD 18 73.96 Quite High
COX-2 inhibitor 13 67.92 Quite High
antagonist 7 66.24 Quite High
tolerance 4 64.00 Quite High
cva 52 62.24 Quite High
Potency 3 55.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 403 99.76 Very High Very High Very High
Leukemia 68 99.52 Very High Very High Very High
Apoptosis 156 99.42 Very High Very High Very High
Papillomavirus Infection 55 98.84 Very High Very High Very High
Thyroid Neoplasm 183 98.52 Very High Very High Very High
Carcinoma 7 98.24 Very High Very High Very High
Colon Cancer 47 96.92 Very High Very High Very High
Cervical Cancer 3 96.48 Very High Very High Very High
Repression 7 95.80 Very High Very High Very High
Alagille Syndrome 6 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine at concentrations of 10(-12) M to 10(-10) M also modulated mRNA expression of early growth related genes (c-fos, c-jun and c-myc).
Transcription (expression) of c-myc associated with morphine
1) Confidence 0.69 Published 1998 Journal Kidney Int. Section Abstract Doc Link 9461094 Disease Relevance 0.49 Pain Relevance 0.76
-catenin ubiquitination led to its translocation into the nucleus, and resultant upregulation of c-myc transcription.
Transcription (transcription) of c-myc in nucleus
2) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.60 Pain Relevance 0.08
However, Stat3 promotes proliferation primarily by stimulating transcription of cyclinB1, cdc2, c-myc and cyclinD1 [55,65,66], along with the induction of the immediate early genes c-jun and c-fos [67] and repression of the cell cycle inhibitor p21 [68].
Transcription (transcription) of c-myc associated with repression
3) Confidence 0.69 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.24 Pain Relevance 0.04
Their effects on c-myc transcription were assayed using a novel variant of fluorescence in situ hybridization that detects c-myc transcription sites in intact nuclei.
Transcription (transcription) of c-myc
4) Confidence 0.69 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.41 Pain Relevance 0.06
arrest and apoptosis, but also downregulated the expression of c-myc mRNA and protein [187].
Transcription (expression) of c-myc associated with apoptosis
5) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.19 Pain Relevance 0.03
In MKN28 cells, the levels of p53, p21waf1/cip1, and c-myc mRNA remained unchanged over the 24-hr treatment with indomethacin, but the p53 protein level was elevated after 4 hr.
Transcription (levels) of c-myc
6) Confidence 0.67 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.93 Pain Relevance 0.12
The mRNA and protein levels of p53, p21waf1/cip1, and c-myc were determined by Northern and Western blotting.
Spec (determined) Transcription (levels) of c-myc
7) Confidence 0.67 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.97 Pain Relevance 0.15
Correlation between the c-myc transcript levels and the thyroid carcinoma differentiation was reported, demonstrating that the less differentiated tumors are associated with a greater abundance of c-myc mRNA [53].


Transcription (abundance) of c-myc in thyroid associated with thyroid neoplasm and cancer
8) Confidence 0.52 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.85 Pain Relevance 0
Although no evidence for gene rearrangements or amplification of the nuclear proto-oncogenes has been noted in thyroid carcinomas, in human MTC samples, both a high frequency of c-myc allelic losses [50] and elevated levels of c-myc and c-jun mRNA have been demonstrated [52].
Transcription (levels) of c-myc in thyroid associated with thyroid neoplasm and carcinoma
9) Confidence 0.52 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.89 Pain Relevance 0
The transcriptional activity of c-myc at the NOXA promoter can be favored by chromatin remodeling or modification proteins (including histone acetyl transferases, with acetylated histone H3 being a classical cofactor for myc).72 HDAC inhibition is also thought to interfere with the targeting of ubiquinated proteins via the aggresome for eventual autophagy/degradation by the lysozome, an alternate pathway to proteasome-mediated degradation.76
Transcription (activity) of c-myc
10) Confidence 0.52 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.51 Pain Relevance 0
Under VPA treatment, transcription of c-myc is dependent upon JNK/SAPK, and ectopic expression of c-myc, leading to more resistant cells in cell cycle arrest, shows the importance of this protein in VPA-mediated activity.
Transcription (transcription) of c-myc
11) Confidence 0.52 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.67 Pain Relevance 0.06
Their effects on c-myc transcription were assayed using a novel variant of fluorescence in situ hybridization that detects c-myc transcription sites in intact nuclei.
Transcription (transcription) of myc
12) Confidence 0.52 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414619 Disease Relevance 0.41 Pain Relevance 0.06
For the c-MYC gene, we found no significant effect of paracetamol on the repair of CPDs, possibly because UV-irradiation is known to induce transcription of the c-MYC gene and enhanced transcription coupled repair might counteract a negative effect of paracetamol on global genome repair.
Transcription (transcription) of c-MYC gene associated with paracetamol
13) Confidence 0.47 Published 1998 Journal Chem. Biol. Interact. Section Abstract Doc Link 9566729 Disease Relevance 0 Pain Relevance 0.65
Nuclear complex, consisting of T-cell factor/lymphoid enhancer factor, beta-catenin, BCL9/BCL9L, and PYGO, activates transcription of canonical WNT target genes such as FGF20, DKK1, WISP1, MYC, CCND1, and Glucagon (GCG).
Transcription (transcription) of MYC in T-cell
14) Confidence 0.37 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17634527 Disease Relevance 0 Pain Relevance 0
Amongst the non-histone acetylation targets that via HDACi induced acetylation could potentially impart anti-cancer effect are transcription factors (p53, c-Myc, Smad7, BCL6, GATA, STAT3, NF-?
Transcription (transcription) of c-Myc associated with cancer
15) Confidence 0.29 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.37 Pain Relevance 0.03
MYC, a transcriptional ?
Transcription (transcriptional) of MYC
16) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.32 Pain Relevance 0.03
An amphotropic replication-incompetent retroviral vector encoding v-myc oncogene (transcribed from mouse leukemia virus LTR plus neomycin-resistant gene transcribed from a SV40 early promotor) was used (Figure 1A).
Transcription (transcribed) of v-myc associated with leukemia
17) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.23 Pain Relevance 0.03
It decreases mRNA expression of the c-MYC oncogene, causes cell-cycle arrest at G0-G1 and acts as an inhibitor of a histone deacetylase.
Transcription (expression) of c-MYC
18) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2993000 Disease Relevance 0.18 Pain Relevance 0.03
The main function of HPV integration is considered to be for the stabilization of viral oncogene transcription [26, 27].
Transcription (transcription) of viral oncogene associated with papillomavirus infection
19) Confidence 0.00 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 1.86 Pain Relevance 0

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