INT73479

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 16.16
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
macrophages 1
erythrocyte 1
lymphocyte 1
cartilage 1
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 488 100.00 Very High Very High Very High
Inflammation 358 100.00 Very High Very High Very High
rheumatoid arthritis 167 99.74 Very High Very High Very High
Spinal cord 72 90.72 High High
Pain 9 90.24 High High
chemokine 80 87.92 High High
Arthritis 232 87.72 High High
headache 3 84.52 Quite High
medulla 16 78.64 Quite High
psoriasis 3 73.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 349 100.00 Very High Very High Very High
Synovitis 21 99.76 Very High Very High Very High
Rheumatoid Arthritis 167 99.74 Very High Very High Very High
Disease 203 99.44 Very High Very High Very High
Cancer 68 98.68 Very High Very High Very High
Necrosis 37 98.44 Very High Very High Very High
Plasmodium Infection 34 98.08 Very High Very High Very High
Hepatocellular Cancer 47 97.84 Very High Very High Very High
Infection 243 97.72 Very High Very High Very High
Melioidosis 171 97.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, although mice treated with 25×106 cells had high variability in IL-2 and IL-10 mRNA expressions in the spleen, they markedly decreased and increased these cytokines respectively.
Positive_regulation (increased) of cytokines in spleen associated with cytokine
1) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.43
With respect to the TH2 cytokines, the concentration of IL4 increased slowly, reaching a maximum concentration by day 29 post-infection in Ninoa-infected mice.
Positive_regulation (increased) of cytokines associated with infection and cytokine
2) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.75 Pain Relevance 0.08
l of plasma were used to quantify the levels of the circulating inflammatory cytokines TNF?
Positive_regulation (circulating) of cytokines in plasma associated with inflammation and cytokine
3) Confidence 0.03 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.64 Pain Relevance 0.45
It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].
Positive_regulation (increased) of cytokines in macrophages associated with cytokine
4) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.85 Pain Relevance 0.05
Interestingly, T-cell derived cytokines (lymphokines) including IL 2, IL 3, and IL 4 are not elevated in G93A mice even at late stages of disease, which led to the suggestion that “lymphocyte contributions to cytokine expression in ALS are likely minor” [38].
Neg (not) Positive_regulation (elevated) of cytokines in lymphocyte associated with disease, motor neuron diseases and cytokine
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.80 Pain Relevance 0.61
In addition, the release of both Plasmodium-derived Hz and merozoites during the erythrocyte burst phase of the disease coincides with the massive induction of pro-inflammatory cytokines, such as IL-1?
Positive_regulation (induction) of cytokines in erythrocyte associated with inflammation, disease and cytokine
6) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 1.06 Pain Relevance 0.22
Hz is involved in the fever observed during the malaria process as intravenous injection of Hz caused thermal deregulation and was associated with the induction of pyrogenic cytokines [3].
Positive_regulation (induction) of cytokines associated with plasmodium infection, fever and cytokine
7) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 1.01 Pain Relevance 0.22
Collection of splenocytes, and the production of concanavalin-A(Con-A)-induced cytokines
Positive_regulation (induced) of cytokines associated with cytokine
8) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.08
Thus, efforts to counteract the pre-existing inflammatory cytokines in RA patients by inducing anti-inflammatory cytokines or neutralizing pro-inflammatory cytokines should be critically evaluated before considering this form of therapy.
Positive_regulation (inducing) of cytokines associated with inflammation, rheumatoid arthritis and cytokine
9) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.29 Pain Relevance 0.72
Thus, efforts to counteract the pre-existing inflammatory cytokines in RA patients by inducing anti-inflammatory cytokines or neutralizing pro-inflammatory cytokines should be critically evaluated before considering this form of therapy.
Positive_regulation (inducing) of cytokines associated with inflammation, rheumatoid arthritis and cytokine
10) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.30 Pain Relevance 0.75
B, which are responsible for activation of numerous innate cytokines and cell-surface activation antigen genes (for review see [43,44]).
Positive_regulation (activation) of cytokines associated with cytokine
11) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.35 Pain Relevance 0.17
Since cytokines play an important role in host defense against B. pseudomallei [2] and OPN is known to act as a proinflammatory mediator able to induce cytokines including IFN-?
Positive_regulation (induce) of cytokines associated with cytokine
12) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.00 Pain Relevance 0.62
Considering that Th1 cytokines serve a protective role in the immune response to experimental melioidosis [9]–[11], we anticipated that OPN deficiency would result in an impaired host defense response due to an attenuated induction of protective Th1 cytokines.
Positive_regulation (induction) of cytokines associated with melioidosis and cytokine
13) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.14 Pain Relevance 0.21
OPN deficiency did not influence the induction of proinflammatory cytokines.


Positive_regulation (induction) of cytokines associated with cytokine
14) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2930856 Disease Relevance 1.80 Pain Relevance 0.14
It is assumed that dying hepatocytes following DEN may activate myeloid cells such as Kupffer cells via TLRs and induce proinflammatory cytokines and hepatomitogens, which enhance the development of HCC [93].
Positive_regulation (induce) of cytokines in myeloid cells associated with hepatocellular cancer and cytokine
15) Confidence 0.01 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.85 Pain Relevance 0.12
Panels A and B in Figure 3 show the concentrations of the Th1 cytokines, IL-2 and IFN-?
Positive_regulation (concentrations) of cytokines associated with cytokine
16) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.09
IL-13, together with IL-2, IL-4, IL-15, bFGF and EGF, were the most important cytokines in distinguishing early RA patients from other patients with early synovitis, with high levels of these cytokines predicting the development of RA.
Positive_regulation (levels) of cytokines associated with synovitis, rheumatoid arthritis and cytokine
17) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.00 Pain Relevance 0.91
Activation of this cascade results in the upregulation of inflammatory cytokines such as IL-2 and interferon (IFN)-?
Positive_regulation (upregulation) of cytokines associated with inflammation and cytokine
18) Confidence 0.00 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.88 Pain Relevance 0.42
Spaceflight, as well as ground-based model systems of spaceflight, have been shown to affect the production and activation of various cytokines including interleukins (IL) and tumor necrosis factor (TNF).
Positive_regulation (activation) of cytokines associated with necrosis, cancer and cytokine
19) Confidence 0.00 Published 1995 Journal J Gravit Physiol Section Abstract Doc Link 11538892 Disease Relevance 0.20 Pain Relevance 0.21
HP 228 is a novel heptapeptide with unnatural amino acids and can effectively restrain lipopolysaccharide (LPS)-induced increased levels of several key cytokines, including plasma TNF alpha, IL-1 beta and IL-6.
Positive_regulation (increased) of cytokines in plasma associated with cytokine
20) Confidence 0.00 Published 1995 Journal J Gravit Physiol Section Abstract Doc Link 11538892 Disease Relevance 0.15 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox