INT73497

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 33
Total Number 37
Disease Relevance 22.60
Pain Relevance 9.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
plasma 3
monocyte 3
urine 2
synovial fluid 1
lymph nodes 1
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 577 100.00 Very High Very High Very High
Inflammation 463 100.00 Very High Very High Very High
Inflammatory response 60 99.92 Very High Very High Very High
Opioid 6 99.84 Very High Very High Very High
Multiple sclerosis 143 99.16 Very High Very High Very High
chemokine 49 99.16 Very High Very High Very High
Adalimumab 211 98.66 Very High Very High Very High
alcohol 16 97.44 Very High Very High Very High
noradrenaline 5 96.48 Very High Very High Very High
headache 10 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 532 100.00 Very High Very High Very High
Cancer 258 100.00 Very High Very High Very High
Infection 172 100.00 Very High Very High Very High
Necrosis 52 100.00 Very High Very High Very High
Disease 381 99.88 Very High Very High Very High
Sepsis 216 99.84 Very High Very High Very High
Asthma 318 99.80 Very High Very High Very High
Systemic Lupus Erythematosus 174 99.72 Very High Very High Very High
Inflammatory Bowel Disease 26 99.54 Very High Very High Very High
Demyelinating Disease 159 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the genetic effect of these variants on IL-10 plasma concentrations was relatively small.
Regulation (effect) of IL-10 in plasma
1) Confidence 0.45 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.54 Pain Relevance 0.04
In the remaining eight patients, after 3 months of IL-10 treatment histology was unchanged in five patients, improved in two patients and deteriorated in one patient.
Neg (unchanged) Regulation (unchanged) of IL-10
2) Confidence 0.39 Published 2001 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 11711774 Disease Relevance 1.29 Pain Relevance 0.10
This study investigated the effect of five days of oral indomethacin treatment (75 mg per day) on the serum concentrations of IL-6, IL-10, IL-12, and TNF-alpha induced by exercising healthy volunteers.
Spec (investigated) Regulation (effect) of IL-10
3) Confidence 0.38 Published 2002 Journal Cytokine Section Abstract Doc Link 12242082 Disease Relevance 0.36 Pain Relevance 0.44
BACKGROUND: Cardiac surgery with cardiopulmonary bypass (CPB) evokes a systemic inflammatory response involving the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha), interleukin (IL)-1, IL-6, IL-8 and anti-inflammatory cytokines such as IL-10.
Regulation (response) of IL-10 associated with necrosis, inflammatory response, inflammation, cancer and cytokine
4) Confidence 0.31 Published 1998 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 9527747 Disease Relevance 0.40 Pain Relevance 0.65
, interleukin (IL)-2, IL-4, IL-5 and IL-10 were measured in supernatants using a cytometric bead array (BD Biosciences).
Regulation (measured) of IL-10
5) Confidence 0.26 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.32 Pain Relevance 0.20
Addition of a neutralizing mAb to IL-4 receptor in primary cultures, supplemented or not with PGE2, prevents the development of IL-4-producing cells but does not abolish the effects of PGE2 on IL-10 and IL-13 as well as T helper (Th)1-associated cytokines.
Neg (not) Regulation (effects) of IL-10 associated with cytokine
6) Confidence 0.26 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.65 Pain Relevance 0.50
IL-10 is known as an anti-inflammatory cytokine [17], but we did not find any significant changes in IL-10 levels during radio-chemotherapy.
Neg (not) Regulation (changes) of IL-10 associated with inflammation and cytokine
7) Confidence 0.25 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2837669 Disease Relevance 0.78 Pain Relevance 0.38
The general influence of exercise on IL-10 has not been investigated formerly in human joint aspirates of synovial fluid and previous studies on serum levels show some inconsistency [20-23].
Regulation (influence) of IL-10 in synovial fluid
8) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945016 Disease Relevance 0.96 Pain Relevance 0.38
In our work we have found that ESW application down-regulate the intracellular levels of TNF-alpha and IL-10 by chondrocytes.
Regulation (regulate) of IL-10 in chondrocytes
9) Confidence 0.21 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 1.08 Pain Relevance 0.43
IL6 is known to be responsible for regulating plasma levels of IL1RA and IL10 [16].
Regulation (regulating) of IL10 in plasma
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.09 Pain Relevance 0.35
, RANTES, histamine: Beckman-Coulter, Krefeld, Germany; IL-4, IL-10, IL-13, soluble intracellular adhesion molecule-1 (sICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM): Bender MedSystems, Vienna, Austria; IL-5, IL-6 high sensitivity, IL-10 high sensitivity, IL-12 p40/p70, soluble leukocytic (sL)-selectin, sE-selectin: R&D Systems GmbH, Wiesbaden, Germany; IL-2, IL-2-receptor, serum and urine neopterin: DPC Biermann GmbH, Bad Nauheim, Germany; IL-4 high sensitivity, IL-11: Natutec, Frankfurt, Germany; IL-12 p70, IL-13: Biozol Diagnostica Ver-trieb GmbH, Eching, Germany; C5a: Behringwerke AG, Marburg, Germany].
Regulation (sensitivity) of IL-10 in urine associated with adhesions
11) Confidence 0.18 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.35 Pain Relevance 0.03
, RANTES, histamine: Beckman-Coulter, Krefeld, Germany; IL-4, IL-10, IL-13, soluble intracellular adhesion molecule-1 (sICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM): Bender MedSystems, Vienna, Austria; IL-5, IL-6 high sensitivity, IL-10 high sensitivity, IL-12 p40/p70, soluble leukocytic (sL)-selectin, sE-selectin: R&D Systems GmbH, Wiesbaden, Germany; IL-2, IL-2-receptor, serum and urine neopterin: DPC Biermann GmbH, Bad Nauheim, Germany; IL-4 high sensitivity, IL-11: Natutec, Frankfurt, Germany; IL-12 p70, IL-13: Biozol Diagnostica Ver-trieb GmbH, Eching, Germany; C5a: Behringwerke AG, Marburg, Germany].
Regulation (sensitivity) of IL-10 in urine associated with adhesions
12) Confidence 0.18 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.36 Pain Relevance 0.03
After no significant modulation during the first 14 hrs post-infection, IL-10 and COX-2 were expressed at a maximum level around D3 after a steady increase notably for IL-10.
Neg (no) Regulation (modulation) of IL-10 associated with infection
13) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 0.49 Pain Relevance 0
However, the results observed with the other two infection models suggest a possible effect of the infective dose on IL-10 expression levels, higher levels being noted in animals infected with a high Leptospira dose (either virulent or not) when compared to their respective counterparts with the same outcome in the LD50 model.
Spec (possible) Regulation (effect) of IL-10 associated with leptospirosis and infection
14) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 0.90 Pain Relevance 0.18
and IL-10 are mutually regulated and that, similar to TNF?
Regulation (regulated) of IL-10
15) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.24 Pain Relevance 0.05
On the other hand, though the relevance of IL-10 was already known in lupus disease, the influence of genetic polymorphisms at the IL-10 promoter on treatment outcome after the use of antimalarials was surprising.
Regulation (influence) of IL-10 associated with disease and systemic lupus erythematosus
16) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.29 Pain Relevance 0.03
Therefore, using logistic regression modeling, we evaluated the influence of single and combined IL-10 and TNF?
Regulation (influence) of IL-10
17) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.20 Pain Relevance 0.15
In inflammatory bowel diseases, disturbed adrenergic regulation of interleukin-10 (IL-10) could be part of the mechanism underlying the modulation of disease activity due to psychological stress [46].
Regulation (regulation) of interleukin-10 in bowel associated with stress, inflammation and disease
18) Confidence 0.16 Published 2008 Journal Biopsychosoc Med Section Body Doc Link PMC2588633 Disease Relevance 0.69 Pain Relevance 1.12
Negative correlations were found between the reduction of HLA-DR expression and the change in cortisol levels for both subpopulations, whereas a negative correlation between interleukin-10 (IL-10) levels and HLA-DR modulation was only observed for CD14HIGH cells.
Regulation (modulation) of IL-10
19) Confidence 0.14 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.06
Negative correlations were found between the reduction of HLA-DR expression and the change in cortisol levels for both subpopulations, whereas a negative correlation between interleukin-10 (IL-10) levels and HLA-DR modulation was only observed for CD14HIGH cells.
Regulation (modulation) of interleukin-10
20) Confidence 0.14 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.06

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