INT73498

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 117
Total Number 120
Disease Relevance 83.85
Pain Relevance 32.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
mast cells 10
T cells 10
Th2 cells 7
lung 5
blood 4
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4594 100.00 Very High Very High Very High
Inflammation 3447 100.00 Very High Very High Very High
metalloproteinase 892 100.00 Very High Very High Very High
chemokine 837 100.00 Very High Very High Very High
rheumatoid arthritis 762 99.96 Very High Very High Very High
adenocard 112 99.76 Very High Very High Very High
antagonist 879 99.52 Very High Very High Very High
fibrosis 103 99.52 Very High Very High Very High
Arthritis 359 98.92 Very High Very High Very High
Catecholamine 242 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3699 100.00 Very High Very High Very High
Rheumatoid Arthritis 774 99.96 Very High Very High Very High
Hyperplasia 182 99.96 Very High Very High Very High
Targeted Disruption 429 99.88 Very High Very High Very High
Asthma 6697 99.84 Very High Very High Very High
Eosinophilia 450 99.78 Very High Very High Very High
Infection 732 99.60 Very High Very High Very High
Nicotine Addiction 298 99.54 Very High Very High Very High
Fibrosis 67 99.52 Very High Very High Very High
Pneumonia 163 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CSF2 and HMOX1 were connected through several genes in the OFF state, including IL13 (interleukin 13), IFNG (interferon gamma), and FN1 (fibronectin 1), which are related to inflammatory responses and wound healing.
Gene_expression (connected) of IL13 associated with inflammatory response and wound healing
1) Confidence 0.44 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.67 Pain Relevance 0.16
CSF2 and HMOX1 were connected through several genes in the OFF state, including IL13 (interleukin 13), IFNG (interferon gamma), and FN1 (fibronectin 1), which are related to inflammatory responses and wound healing.
Gene_expression (connected) of interleukin 13 associated with inflammatory response and wound healing
2) Confidence 0.44 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900289 Disease Relevance 0.67 Pain Relevance 0.16
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Gene_expression (production) of IL-13 in naive T cells associated with necrosis and cancer
3) Confidence 0.41 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.79 Pain Relevance 0.55
Human GBMs express high levels of the IL-13 receptor in comparison to normal brain and therefore this genetically engineered drug should be highly specific to tumor cells [6, 7].
Gene_expression (express) of IL-13 in brain associated with cancer
4) Confidence 0.41 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.67 Pain Relevance 0
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Gene_expression (produced) of IL-13 in Th2 cells associated with asthma
5) Confidence 0.38 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.21 Pain Relevance 0.15
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Gene_expression (produced) of interleukin 13 in Th2 cells associated with asthma
6) Confidence 0.38 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.27 Pain Relevance 0.15
In contrast, ASA did not affect IL-13, interferon-gamma, and IL-2 expression.
Gene_expression (expression) of IL-13
7) Confidence 0.38 Published 2001 Journal Blood Section Abstract Doc Link 11238116 Disease Relevance 0.09 Pain Relevance 0.29
Thus, activated M1, unlike alternatively activated M2, mononuclear phagocytes express mPGES-1, and IL-4, IL-13, and IL-10 tune expression of this key enzyme in prostanoid metabolism.
Gene_expression (expression) of IL-13 in mononuclear phagocytes
8) Confidence 0.38 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.23 Pain Relevance 0.25
Thus, activated M1, unlike alternatively activated M2, mononuclear phagocytes express mPGES-1, and IL-4, IL-13, and IL-10 tune expression of this key enzyme in prostanoid metabolism.
Gene_expression (express) of IL-13 in mononuclear phagocytes
9) Confidence 0.38 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.24 Pain Relevance 0.25
Together, these results indicate that ETS exposure augments the expression and secretion of IL-13 in allergic asthma.
Gene_expression (expression) of IL-13 associated with asthma and nicotine addiction
10) Confidence 0.37 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.78 Pain Relevance 0.27
It was shown that IL-13 levels were highly increased in patients with asthma (P < .005).
Gene_expression (levels) of IL-13 associated with asthma
11) Confidence 0.32 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.70 Pain Relevance 0.15
Also, a positive correlation between IL-13 levels and serum IgE concentrations (r(s) = 0.55) was found in children with allergic asthma.
Gene_expression (levels) of IL-13 associated with asthma
12) Confidence 0.32 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.63 Pain Relevance 0.15
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Gene_expression (levels) of IL-13 in naive T cells associated with necrosis and cancer
13) Confidence 0.32 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.78 Pain Relevance 0.54
CB, a recombinant cytotoxin composed of the human interleukin -13 (IL-13) and a truncated form of the Pseudomonas aeruginosa Exotoxin A, has been shown to be highly toxic to cells expressing the IL-13 receptor [4, 5].
Gene_expression (expressing) of IL-13 associated with pseudomonas infection
14) Confidence 0.32 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.78 Pain Relevance 0
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Gene_expression (production) of IL-13 associated with cytokine
15) Confidence 0.28 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.69 Pain Relevance 0.29
The highest levels of IL8 and IL13 were observed in children with polyarticular JIA.
Gene_expression (levels) of IL13 associated with arthritis
16) Confidence 0.27 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.13 Pain Relevance 0.58
As an example, IL13 is important in the pathogenesis of asthma and there is interest to explore its use as a systemic disease biomarker of asthma as well as a PD biomarker for therapeutics targeting IL13 (St Ledger et al., 2009).
Gene_expression (targeting) of IL13 associated with asthma and disease
17) Confidence 0.27 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.60 Pain Relevance 0.23
These are notable because of their production from IL4- or IL13-“alternatively activated” members of the mononuclear phagocyte system, which includes monocytes, macrophages, and dendritic cells [22], [23].
Gene_expression (production) of IL13 in dendritic cells
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.17 Pain Relevance 0.26
and low IL-13 are expected), and the latter arguing against TH2-like disease, such as asthma (where high IL-4 and IL-13 are expected).
Gene_expression (expected) of IL-13 associated with asthma and disease
19) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.79 Pain Relevance 0.39
and low IL-13 are expected), and the latter arguing against TH2-like disease, such as asthma (where high IL-4 and IL-13 are expected).
Gene_expression (expected) of IL-13 associated with asthma and disease
20) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.85 Pain Relevance 0.38

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