INT73499

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 20.03
Pain Relevance 6.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
blood 2
nasal 1
Th2 cells 1
naive T cells 1
T cells 1
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 898 100.00 Very High Very High Very High
Inflammation 578 100.00 Very High Very High Very High
Arthritis 114 99.48 Very High Very High Very High
rheumatoid arthritis 109 99.44 Very High Very High Very High
imagery 54 95.68 Very High Very High Very High
agonist 46 94.80 High High
alcohol 2 90.04 High High
fibrosis 22 87.12 High High
Inflammatory mediators 11 83.36 Quite High
corticosteroid 14 81.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 606 100.00 Very High Very High Very High
Syndrome 31 99.96 Very High Very High Very High
Infection 136 99.66 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 666 99.64 Very High Very High Very High
Juvenile Chronic Polyarthritis 74 99.48 Very High Very High Very High
Rheumatoid Arthritis 111 99.44 Very High Very High Very High
Asthma 755 99.28 Very High Very High Very High
Eosinophilic Esophagitis 106 99.12 Very High Very High Very High
Disease 256 98.96 Very High Very High Very High
Cancer 87 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-13 levels are increased in the airways of patients with asthma [7,8].
Positive_regulation (increased) of IL-13 associated with asthma
1) Confidence 0.39 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.00 Pain Relevance 0.52
Noxious heat but not experimental inflammation significantly increased IL-7 and IL-13.
Positive_regulation (increased) of IL-13 associated with inflammation
2) Confidence 0.38 Published 2008 Journal Pain Section Abstract Doc Link 18396374 Disease Relevance 0.99 Pain Relevance 0.73
PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.
Positive_regulation (levels) of IL-13 in naive T cells associated with necrosis and cancer
3) Confidence 0.37 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.79 Pain Relevance 0.55
To further elucidate which factors are essential to respond to this type of therapy, we assessed MRIs of all patients receiving IL13-PE38QQR in respect to catheter positioning scores, overall catheter placement scores, local recurrence of disease, imaging changes associated with the therapy as well as the effect of these variables on clinical outcome.


Positive_regulation (receiving) of IL13-PE38QQR associated with disease, imagery and recurrence
4) Confidence 0.27 Published 2010 Journal J Neurooncol Section Body Doc Link PMC2996533 Disease Relevance 0.54 Pain Relevance 0.05
It was shown that IL-13 levels were highly increased in patients with asthma (P < .005).
Positive_regulation (increased) of IL-13 associated with asthma
5) Confidence 0.22 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.71 Pain Relevance 0.15
IL8, IL10 and IL13 were significantly elevated in specific JIA subtypes compared to controls (Table 4).
Positive_regulation (elevated) of IL13 associated with arthritis
6) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.17 Pain Relevance 0.61
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Positive_regulation (levels) of IL-13 in blood
7) Confidence 0.15 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.72 Pain Relevance 0.14
A microarray study of whole blood gene expression during secondary DV infection has shown early upregulation of IL-13 transcripts in acute samples from DHF patients [12].
Positive_regulation (upregulation) of IL-13 in blood associated with flavivirus infection and infection
8) Confidence 0.13 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.72 Pain Relevance 0.04
Supernatants were harvested for measuring IL-6, IL-8, and IL-13 by ELISA and cell viability and numbers of the culture were analyzed.


Positive_regulation (measuring) of IL-13
9) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.24 Pain Relevance 0.31
Epinephrine did not enhance IL-13 promoter activity suggesting that post-transcriptional mechanisms may be involved in the IL-13 induction.
Neg (not) Positive_regulation (enhance) of IL-13
10) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.10
Epinephrine did not enhance IL-13 promoter activity suggesting that post-transcriptional mechanisms may be involved in the IL-13 induction.
Positive_regulation (induction) of IL-13
11) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.14
plus epinephrine compared to either stimulus alone nor was the promotor activity of IL-13 increased by the double stimulus as seen by luciferase activity of a IL-13 reporter gene construct.
Neg (nor) Positive_regulation (increased) of IL-13
12) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.44 Pain Relevance 0.19
at 10 ng/ml significantly increased IL-13 promotor activity as detected by luciferase expression (data not shown).
Positive_regulation (increased) of IL-13
13) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.09
was a good inducer of IL-13 transcription while epinephrine alone only minimally induced IL-13 mRNA.
Positive_regulation (induced) of IL-13
14) Confidence 0.11 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.10
IL-13 increases were associated with EoE subjects with concomitant food allergies (data not shown).
Positive_regulation (increases) of IL-13 associated with food hypersensitivity and eosinophilic esophagitis
15) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.42 Pain Relevance 0
Vaccination significantly inhibits increase in inflammatory cell number and IL-13 and IL-5 levels in BAL.
Positive_regulation (increase) of IL-13 associated with inflammation
16) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.12
We have recently shown that in human memory CD4 T cells, stabilization of IL-4 and IL-13 mRNA by CD28 stimulation is mediated by p38 MAPK [60].
Positive_regulation (stabilization) of IL-13 in T cells
17) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.40 Pain Relevance 0.13
Whereas the expression of IL-4 and IL-5 induced by stimulation of in vitro-differentiated murine Th2 cells with concanavalin A remained unaffected by the chemical inhibitor of p38 SB203580 or a dominant-negative mutant of p38, the induction of IL-4 by phorbol 12-myristate 13-acetate and ionomycin or of IL-5 and IL-13 by phorbol 12-myristate 13-acetate and dibutyryl cAMP was partly abrogated by SB203580 [59,66].
Positive_regulation (induction) of IL-13 in Th2 cells
18) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.06
Early onset RA patients had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF, and bFGF when compared with patients with established RA.
Positive_regulation (elevated) of IL-13 associated with rheumatoid arthritis
19) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.53 Pain Relevance 0.97
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Positive_regulation (lavage) of IL-13 in nasal associated with rhinitis
20) Confidence 0.04 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.86 Pain Relevance 0.41

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