INT7350

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 2.89
Pain Relevance 11.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Anpep) peptidase activity (Anpep)
Anatomy Link Frequency
brain 3
striatum 2
hippocampus 2
cortex 2
muscle 1
Anpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 77 100.00 Very High Very High Very High
Hippocampus 5 100.00 Very High Very High Very High
dexamethasone 3 99.84 Very High Very High Very High
Analgesic 23 99.76 Very High Very High Very High
narcan 4 99.12 Very High Very High Very High
bradykinin 4 99.00 Very High Very High Very High
Morphine 10 98.76 Very High Very High Very High
withdrawal 5 98.24 Very High Very High Very High
c fibre 2 98.24 Very High Very High Very High
substance P 10 98.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 100.00 Very High Very High Very High
Sprains And Strains 1 98.66 Very High Very High Very High
Substance Withdrawal Syndrome 2 98.24 Very High Very High Very High
Pressure And Volume Under Development 4 96.56 Very High Very High Very High
Gallstones 3 94.16 High High
Edema 6 92.96 High High
Leukemia 1 90.60 High High
Hypertension 1 87.76 High High
Necrosis 2 85.16 High High
Liver Disease 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This co-localization confirms the physiological implication of aminopeptidase N in the inactivation of enkephalins accounting for the requirement of dual inhibition of neutral endopeptidase and aminopeptidase N to observe highly significant morphine-like effects induced by the protected endogenous opioid peptides.
Negative_regulation (inhibition) of aminopeptidase N associated with endogenous opioid, enkephalin and morphine
1) Confidence 0.59 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672613 Disease Relevance 0.09 Pain Relevance 0.80
In order to evaluate the possible advantages of potentiating the effects of the endogenous enkephalins, to obtain analgesia without the serious drawbacks of morphine, it was essential to design systemically active compounds which inhibit the two metabolizing enzymes, aminopeptidase N (APN) and neutral endopeptidase 24.11 (NEP).
Negative_regulation (inhibit) of APN associated with enkephalin, morphine and analgesia
2) Confidence 0.58 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1352352 Disease Relevance 0 Pain Relevance 0.37
In order to evaluate the possible advantages of potentiating the effects of the endogenous enkephalins, to obtain analgesia without the serious drawbacks of morphine, it was essential to design systemically active compounds which inhibit the two metabolizing enzymes, aminopeptidase N (APN) and neutral endopeptidase 24.11 (NEP).
Negative_regulation (inhibit) of aminopeptidase N associated with enkephalin, morphine and analgesia
3) Confidence 0.58 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1352352 Disease Relevance 0 Pain Relevance 0.37
The effect of N-[(R,S)-2-benzyl-3[(S)-(2-amino-4-methylthio)butyldithiol]-1-oxopropyl]-L-phenylalanine benzyl ester (RB101), a dual inhibitor of the enkephalin-degrading enzymes, neutral endopeptidase and aminopeptidase N, was assessed in anaesthetised rats on the C-fibre reflex elicited by electrical stimulation within the sural nerve territory and recorded from the ipsilateral biceps femoris muscle.
Negative_regulation (inhibitor) of aminopeptidase N in muscle associated with c fibre and enkephalin
4) Confidence 0.56 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12079685 Disease Relevance 0.06 Pain Relevance 0.41
Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex.
Negative_regulation (decreases) of aminopeptidase N in striatum associated with enkephalin
5) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8851165 Disease Relevance 0 Pain Relevance 0.26
Further, aminopeptidase N activity was decreased in P2 membranes isolated from either the cortex or striatum of haloperidol-treated animals.
Negative_regulation (decreased) of aminopeptidase N in cortex
6) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8851165 Disease Relevance 0 Pain Relevance 0.25
In rodent strains, intracerebraventricular (i.c.v.) infusions of APN reduces, while inhibitors of APN activity have a pressor effect on blood pressure.
Negative_regulation (inhibitors) of APN in blood associated with sprains and strains
7) Confidence 0.48 Published 2008 Journal Heart Fail Rev Section Abstract Doc Link 18008160 Disease Relevance 0.54 Pain Relevance 0.21
Actinonin, previously isolated as an antibiotic and shown to be an inhibitor of aminopeptidase M (EC 3.4.11.2), has now been shown to inhibit three enkephalin-degrading enzymes from guinea-pig striatum.
Negative_regulation (inhibitor) of aminopeptidase M in striatum associated with enkephalin
8) Confidence 0.48 Published 1987 Journal Life Sci. Section Abstract Doc Link 3298909 Disease Relevance 0 Pain Relevance 0.49
APN mRNA levels, semi-quantified by RT-PCR, were decreased at stage II and increased at stage V, in frontal cortex-olfactory tubercle, and hippocampus.
Negative_regulation (decreased) of APN in olfactory tubercle associated with urological neuroanatomy and hippocampus
9) Confidence 0.46 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.10 Pain Relevance 0.28
Subchronic administration of haloperidol decreased the activity of aminopeptidase N in the frontal cortex and caudate-putamen.
Negative_regulation (decreased) of aminopeptidase N in caudate-putamen associated with urological neuroanatomy
10) Confidence 0.46 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8613907 Disease Relevance 0.32 Pain Relevance 0.18
Given the high efficiency of beta-mercaptoalkylamines as APN inhibitors and of N-(mercaptoacyl) amino acids as NEP inhibitors, compounds associating these molecules through disulfide or thioester bonds, which are known to increase lipophilicity and to favor passage across the blood-brain barrier, have been synthesized.
Negative_regulation (inhibitors) of APN in brain
11) Confidence 0.38 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1352352 Disease Relevance 0 Pain Relevance 0.39
Thus, the activity of aminopeptidase N in the hippocampus and soluble puromycin-sensitive aminopeptidase in the frontal cortex were found to be lower in rats experiencing naloxone precipitated withdrawal symptoms, compared to the corresponding controls.
Negative_regulation (lower) of aminopeptidase N in hippocampus associated with narcan, urological neuroanatomy, hippocampus and withdrawal
12) Confidence 0.36 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12573804 Disease Relevance 0.45 Pain Relevance 1.31
These data suggest that the haloperidol-induced decrease in [Met5]enkephalin metabolism results, at least in part, from a reduction in the activity of aminopeptidase N.
Negative_regulation (reduction) of aminopeptidase N associated with enkephalin
13) Confidence 0.36 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8851165 Disease Relevance 0 Pain Relevance 0.25
Bestatin, another aminopeptidase M inhibitor, also effectively suppressed the degradation of MKA before absorption, whereas it only slightly increased CLp.
Negative_regulation (inhibitor) of aminopeptidase M
14) Confidence 0.35 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616421 Disease Relevance 0 Pain Relevance 0.05
Three tested inhibitors, bacitracin, amastatin and puromycin, effectively inhibited the activities of APM, APN and DPP IV except for APB.
Negative_regulation (inhibited) of APN
15) Confidence 0.34 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.17
Three tested inhibitors, bacitracin, amastatin and puromycin, effectively inhibited the activities of APM, APN and DPP IV except for APB.
Negative_regulation (inhibited) of APM
16) Confidence 0.34 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.17
Also, the aminopeptidase M activity on Met-enk can be inhibited in the presence of Ac-Met-enk, which acts as a mixed-type inhibitor with the inhibition constant (K(i)) of I x 10(-3) M.
Negative_regulation (inhibited) of aminopeptidase M
17) Confidence 0.28 Published 1999 Journal Peptides Section Abstract Doc Link 10503775 Disease Relevance 0 Pain Relevance 0.39
The effect of N-terminal acetylation and the inhibition activity of acetylated enkephalins on the aminopeptidase M-catalyzed hydrolysis of enkephalins.
Negative_regulation (inhibition) of aminopeptidase M associated with enkephalin
18) Confidence 0.20 Published 1999 Journal Peptides Section Title Doc Link 10503775 Disease Relevance 0 Pain Relevance 0.65
This effect was increased by combination of captopril with diprotin A or phosphoramidon, but not by captopril associated with amastatin, an inhibitor of aminopeptidase M (AmM).
Negative_regulation (inhibitor) of aminopeptidase M
19) Confidence 0.18 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938667 Disease Relevance 0.31 Pain Relevance 0.44
Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex.
Negative_regulation (decreases) of aminopeptidase N in cortex associated with enkephalin
20) Confidence 0.17 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8851165 Disease Relevance 0 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox